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Lucentis 10 mg/ml solution for injection in pre-filled syringe

DRUG7 trials

Sponsors

Abbvie Deutschland GmbH & Co. KG, F. Hoffmann-La Roche AG, AbbVie Deutschland GmbH & Co. KG, Opthea Limited, Medical University Of Vienna

Conditions

Neovascular Age-Related Macular Degeneration (nAMD)Neovascular age-related macular degenerationNeovascular age-related macular degeneration (nAMD)Neovascular age-related macular degeneration (wet AMD)neovasclar AMD

Phase 3

A Randomized, Partially Masked, Controlled, Phase 3 Clinical Study to Evaluate the Efficacy and Safety of RGX-314 Gene Therapy in Participants with nAMD (ASCENT)
Active, not recruitingCTIS2023-503666-23-00
Abbvie Deutschland GmbH & Co. KGNeovascular age-related macular degeneration
Start: 2024-06-07Target: 216Updated: 2025-08-20
A Phase IIIb, Global, Multicenter, Randomized, Visual Assessor−Masked Study of the Efficacy, Safety, and Pharmacokinetics of a 36-Week Refill Regimen for the Port Delivery System with Ranibizumab in Patients with Neovascular Age-Related Macular Degeneration (Velodrome)
Active, not recruitingCTIS2023-507130-24-00
F. Hoffmann-La Roche AGNeovascular age-related macular degeneration (nAMD)
Start: 2021-10-22Target: 183Updated: 2025-09-22
A Multicenter, Open-Label Extension Study to Evaluate the Long-Term Safety and Tolerability of the Port Delivery System with Ranibizumab in Patients with Neovascular Age-Related Macular Degeneration
Active, not recruitingCTIS2023-507131-38-00
F. Hoffmann-La Roche AGNeovascular Age-Related Macular Degeneration (nAMD)
Start: 2022-05-16Target: 191Updated: 2025-09-23
A Phase 3, Multicentre, Double-masked, Randomised Study to Evaluate the Efficacy and Safety of Intravitreal OPT-302 in Combination with Ranibizumab, Compared with Ranibizumab Alone, in Participants with Neovascular Age-related Macular Degeneration (nAMD)
CompletedCTIS2024-512879-13-00
Opthea LimitedNeovascular age-related macular degeneration (wet AMD)
Start: 2021-09-23End: 2025-03-31Target: 298Updated: 2025-04-23
A phase IIIb, Multicenter, Single-Arm Study Assessing the Effectiveness, Safety and Patient Reported Outcomes of a 36-week Refill Exchange Regimen for the Port Delivery System with Ranibizumab in Patients with Neovascular Age-Related Macular Degeneration
RecruitingCTIS2024-516924-32-00
F. Hoffmann-La Roche AGNeovascular Age-Related Macular Degeneration (nAMD)
Start: 2025-10-17Target: 164Updated: 2025-09-15
A Randomized, Controlled, Partially Masked, Phase 3b Study to Assess the Injection Burden, Efficacy, Safety, and Long-Term Preservation of Visual Acuity of Surabgene Lomparvovec (ABBV-RGX-314) in a Real-World Context in Subjects with Neovascular Age-Related Macular Degeneration (nAMD)
RecruitingCTIS2024-512298-28-00
AbbVie Deutschland GmbH & Co. KGNeovascular age-related macular degeneration
Start: 2025-12-18Target: 272Updated: 2026-01-13

Phase 4