LPS
Sponsors
Medical University of Vienna, Centre Hospitalier Universitaire Brugmann, Radboud University Medical Center, GlaxoSmithKline, Pfizer
Conditions
Alzheimer DiseaseAnakinraArthritis, RheumatoidDexamethasoneDiabetes Mellitus Type 1EndotoxemiaHealthyHealthy Volunteers
Early Phase 1
A Study Exploring the Use of Vaccine and Antigen Challenges for Immune Monitoring in Healthy Participants
CompletedNCT03953196
Start: 2019-04-08End: 2019-12-26Updated: 2025-02-03
Peripheral Benzodiazepine Receptors (PBR28) Brain PET Imaging With Lipopolysaccharide Challenge for the Study of Microglia Function in Alzheimer's Disease
CompletedNCT04057807
Start: 2018-04-15End: 2022-07-27Updated: 2024-02-05
Phase 1
Ethnic Differences in the Inflammatory Response in Systemic Inflammation
CompletedNCT00284869
Start: 2006-01-31End: 2006-04-30Target: 32Updated: 2006-09-13
A Study to Investigate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Single Doses of Inhaled GSK1995057
CompletedNCT01587807
Start: 2012-03-28End: 2012-11-19Updated: 2019-06-27
A Study To Evaluate The Safety And Effects On The Body Of An Investigational Drug Using An Endotoxin-Induced Inflammatory Response Model
TerminatedNCT01965600
Start: 2014-03-31End: 2015-02-28Updated: 2016-08-02
Brain Biomarker on Inflammation Response
WithdrawnNCT03271814
Start: 2025-01-01End: 2025-12-15Updated: 2023-12-05
First-time-in-Human (FTIH) Study to Evaluate Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Single (in Both Fed and Fasted States) or Repeat Doses of GSK3358699
TerminatedNCT03426995
Start: 2018-03-13End: 2019-05-02Updated: 2020-12-02
Neural Response to Inflammatory Challenge in Major Depressive Disorder
RecruitingNCT04751331
Start: 2021-05-15End: 2027-09-30Target: 180Updated: 2025-03-04
Phase 4
The Effects of Oral Dipyridamole Treatment on the Innate Immune Response During Human Endotoxemia
CompletedNCT01091571
Start: 2010-03-31End: 2010-10-31Target: 30Updated: 2010-11-05
Vorapaxar in the Human Endotoxemia Model
CompletedNCT02875028
Start: 2016-06-30End: 2016-11-30Updated: 2020-01-10
Immunomodulatory Effects of Dexamethasone, Tocilizumab and Anakinra During Experimental Human Endotoxemia
RecruitingNCT06624436
Start: 2024-10-24End: 2025-12-31Target: 52Updated: 2025-04-04
Unknown Phase
Inflammatory Markers in Sputum After LPS Inhalation
NCT01081392
Start: 2010-01-31End: 2010-05-31Updated: 2010-03-05
A Study of Intracellular Signaling in Muscle and Fat Cells During Ketosis
CompletedNCT02157155
Start: 2014-06-30End: 2015-09-30Updated: 2015-12-02
Whey Protein Study - Identification of Sustainable Satiety
CompletedNCT02246543
Start: 2013-08-31End: 2015-10-31Updated: 2016-03-24
The Effects of Preceding LPS Administration on the Fluenz-induced Immune Response
CompletedNCT02642237
Start: 2015-12-31End: 2018-02-28Updated: 2019-05-14
The Effects of Human Endotoxemia on Functional Capacity of Hematopoietic Stem and Progenitor Cells
CompletedNCT05570643
Start: 2018-01-05End: 2018-06-28Updated: 2022-10-06