Loxapine

DRUG7 trials

Sponsors

Les Hopitaux Universitaires De Strasbourg, Assistance Publique - Hôpitaux de Paris, University Hospital, Rouen, Janssen Scientific Affairs, LLC, University of Witten/Herdecke

Conditions

Acute Agitated PatientsAgitation,PsychomotorHaloperidol Causing Adverse Effects in Therapeutic UseLorazepam Causing Adverse Effects in Therapeutic UseLoxapine Causing Adverse Effects in Therapeutic UseNeuropathic PainPatient with a diagnosis of schizophrenia spectrum disorder (SSD): schizophreniaPsychomotor Agitation

Phase 2

Tolerability and Analgesic Efficacy of Loxapine in Patients With Refractory, Chemotherapy-induced Neuropathic Pain

TerminatedNCT02820519

University of Witten/HerdeckeNeuropathic Pain

Start: 2016-06-07End: 2017-05-04Updated: 2022-07-01

Phase 3

Randomized Double-blind Trial of Midazolam and Loxapine in Agitated Patients

TerminatedNCT00290082

University Hospital, RouenAcute Agitated Patients

Start: 2005-12-31End: 2007-10-31Target: 120Updated: 2015-03-11

A prospective, randomized, and controlled study comparing two treatment strategies (Dose REduction of Antipsychotics vs. Maintenance treatment) in patients with schizophrenia spectrum disorder after Stratification based on patients’ psychotic PHENotype: a personalized medicine approach

Not yet recruitingCTIS2023-509558-80-00

Les Hopitaux Universitaires De StrasbourgPatient with a diagnosis of schizophrenia spectrum disorder (SSD): schizophrenia, schizoaffective disorder or brief psychotic episode according to DSM-5, schizophreniform

Target: 288Updated: 2025-07-17

Phase 4

Loxapine in the Management of Restlessness During Mechanical Ventilation Weaning

CompletedNCT01193816

Assistance Publique - Hôpitaux de ParisRestlessness

Start: 2011-05-31End: 2014-07-31Updated: 2014-07-18

Inhaled Loxapine vs Intramuscular (IM) Haloperidol + Lorazepam for Agitation

TerminatedNCT03110900

University of ArkansasAgitation,Psychomotor, Haloperidol Causing Adverse Effects in Therapeutic Use, Lorazepam Causing Adverse Effects in Therapeutic Use +1

Start: 2017-09-30End: 2018-04-04Updated: 2018-06-11

Unknown Phase

Loxapine and Weaning From Ventilator

CompletedNCT00122733

Assistance Publique - Hôpitaux de ParisPsychomotor Agitation, Respiratory Insufficiency

Start: 2005-12-31End: 2006-12-31Updated: 2007-07-23

Family Intervention in Recent Onset Schizophrenia Treatment (FIRST)

CompletedNCT02600741

Janssen Scientific Affairs, LLCSchizophrenia

Start: 2015-07-24End: 2018-07-05Updated: 2019-01-23

Related Papers

Telehealth-Based Psychoeducation for Caregivers: The Family Intervention in Recent-Onset Schizophrenia Treatment Study

JMIR Mental Health2022-04-1520 citations

Loxapine for Treatment of Patients With Refractory, Chemotherapy-Induced Neuropathic Pain: A Prematurely Terminated Pilot Study Showing Efficacy But Limited Tolerability

Frontiers in Pharmacology2019-07-2513 citations

Loxapine to control agitation during weaning from mechanical ventilation.

2017-09-063 citations

SA105. Characteristics of Patients With Recent-Onset Schizophrenia and Their Caregivers: Is There a Correlation With Caregiver Burden?

Schizophrenia Bulletin2017-03-01