Low-dose radiotherapy

RADIATION19 trials

Sponsors

Centro di Riferimento Oncologico - Aviano, Grupo de Investigación Clínica en Oncología Radioterapia, You Lu, Sichuan Cancer Hospital and Research Institute, Fifth Affiliated Hospital, Sun Yat-Sen University

Conditions

ChemotherapyColorectal Cancer (CRC)DurvalumabEsophageal Squamous Cell CarcinomaExtensive-stage Small-cell Lung CancerGastric CancerGastric or Gastroesophageal Junction AdenocarcinomaHead and Neck Squamous Cell Carcinoma

Phase 1

Safety and Tolerability of LDRT+Sugemalimab+Chemotherapy+Olaparib for First-Line Treatment of SLFN-11 Positive ES-SCLC

RecruitingNCT06217757

Sichuan UniversityExtensive-stage Small-cell Lung Cancer, Lung Cancer

Start: 2024-04-18End: 2027-03-20Target: 45Updated: 2024-05-13

Phase 1b/2 Study of LDRT in Combination With AK104 Plus Chemotherapy as First-line Treatment for ES-SCLC

RecruitingNCT06477523

Sichuan UniversitySCLC, Extensive Stage

Start: 2024-05-16End: 2026-12-31Target: 57Updated: 2024-06-27

Low-dose Radiotherapy Combined with Concurrent Chemotherapy, Toripalimab and Tifcemalimab in the Treatment of ES-SCLC

Not yet recruitingNCT06732258

Sichuan UniversityExtensive-stage Small-cell Lung Cancer

Start: 2025-01-10End: 2028-02-29Target: 12Updated: 2024-12-27

LDRT Combined With Pucotenlimab and Standard Therapy for Advanced Pancreatic Cancer: A Single-Arm Study

RecruitingNCT07312422

Zhejiang Provincial People's HospitalLDRT, Pancreatic Cancer, PD-1 Inhibitor +2

Start: 2025-09-30End: 2026-10-30Target: 10Updated: 2026-01-26

Phase 2

Low-dose Radiotherapy for Diffuse Large B-cell Lymphoma

Centro di Riferimento Oncologico - AvianoLymphoma

Start: 2011-07-31End: 2016-06-30Target: 25Updated: 2016-06-17

Low-dose Radiotherapy Combined With Durvalumab, Chemotherapy(EP) in the Treatment of ES-SCLC

Active, not recruitingNCT05092412

You LuDurvalumab, Extensive-stage Small-cell Lung Cancer, Lung Cancer

Start: 2022-03-02End: 2025-06-30Updated: 2024-01-12

The Efficacy and Safety of Neoadjuvant Low-dose Radiotherapy Combined With Chemoimmunotherapy in Locally Advanced HNSCC

RecruitingNCT05343325

Fifth Affiliated Hospital, Sun Yat-Sen UniversityHead and Neck Squamous Cell Carcinoma, Neoadjuvant Treatment

Start: 2022-03-09End: 2027-03-31Target: 25Updated: 2022-12-29

Low-dose Radiotherapy in iNHL

Chinese Academy of Medical SciencesIndolent Lymphoma, Low-dose Radiotherapy

Start: 2022-05-01End: 2025-01-01Target: 73Updated: 2022-09-16

The Efficacy and Safety of Low-dose Radiotherapy Combined With Sintilimab and Temozolomide in Recurrent Glioblastoma

RecruitingNCT06220552

Fifth Affiliated Hospital, Sun Yat-Sen UniversityRecurrent Glioblastoma

Start: 2023-12-27End: 2027-12-30Target: 20Updated: 2024-01-24

Low-dose Radiation Combined With Neoadjuvant Immunochemotherapy for Esophageal Squamous Cell Carcinoma

RecruitingNCT06446726

Sichuan UniversityEsophageal Squamous Cell Carcinoma

Start: 2024-06-30End: 2026-12-30Target: 30Updated: 2025-06-06

AK104 and Low-dose Radiation in Recurrent/Metastatic HNSCC After Failure of First-line Systemic Therapy

RecruitingNCT06494995

Fudan UniversityHead and Neck Squamous Cell Carcinoma

Start: 2024-07-03End: 2028-07-01Target: 52Updated: 2025-06-04

Low-dose Radiotherapy Combined With Chemotherapy and AK112 as Second-line Treatment in Patients With Advanced G/GEJ Cancer

RecruitingNCT06791148

The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical SchoolGastric Cancer

Start: 2024-07-10End: 2027-12-10Target: 45Updated: 2025-01-24

Low-Dose Radiotherapy and Anti-PD-1 Immunotherapy as Neoadjuvant Treatment for Resectable Locally Advanced Head and Neck Squamous Cell Carcinoma

RecruitingNCT07371234

Xiwei XULocally Advanced Head and Neck Squamous Cell Carcinoma

Start: 2025-12-15End: 2028-12-30Target: 22Updated: 2026-02-03

Perioperative Chemotherapy With Low-Dose Radiotherapy and Tislelizumab for Locally Advanced Gastric or Gastroesophageal Junction Adenocarcinoma

Not yet recruitingNCT07408609

Jiangsu Cancer Institute & HospitalGastric or Gastroesophageal Junction Adenocarcinoma

Start: 2026-02-26End: 2031-02-20Target: 114Updated: 2026-02-13

Low-Dose Radiotherapy to Sensitize Pucotenlimab Plus CAPEOX for pMMR Locally Advanced Rectal Cancer

RecruitingNCT07448142

Sun Yat-sen UniversityColorectal Cancer (CRC)

Start: 2026-03-15End: 2032-09-01Target: 50Updated: 2026-03-04

Phase 3

IC Plus Low-dose Radiation Plus Cadonilimab in LANPC

RecruitingNCT05941741

Sun Yat-sen UniversityChemotherapy, Immune Checkpoint Inhibitor, Nasopharyngeal Carcinoma +1

Start: 2024-01-10End: 2029-12-01Target: 380Updated: 2026-03-18

Unknown Phase

Low Dose Anti-inflammatory Radiotherapy for the Treatment of Pneumonia by COVID-19

Grupo de Investigación Clínica en Oncología RadioterapiaPneumonia, Viral

Start: 2020-06-05End: 2021-11-01Target: 106Updated: 2021-07-30

Neoadjuvant Chemotherapy and Low-dose Radiotherapy Sequential Concurrent Chemoradiotherapy for Locally Advanced Nasopharyngeal Carcinoma

CompletedNCT05292027

Sichuan Cancer Hospital and Research InstituteNasopharyngeal Carcinoma

Start: 2022-03-26End: 2024-12-12Updated: 2024-12-31

Low-dose Radiotherapy and Neoadjuvant Chemotherapy Sequential Concurrent Chemoradiotherapy for Locally Advanced Nasopharyngeal Carcinoma

Sichuan Cancer Hospital and Research InstituteLocally Advanced Nasopharyngeal Carcinoma

Start: 2022-08-01End: 2023-07-01Target: 80Updated: 2022-08-17

Related Papers

Abstract 250: Targeting DNA damage repair pathway and CCR2+ myeloid cell to overcome radioimmunotherapy resistance in small cell lung cancer.

Cancer Research2026-04-03

Two cycles of neoadjuvant therapy with low-dose radiotherapy, PD-1 inhibitor tislelizumab, albumin-bound paclitaxel, and cisplatin for resectable locally advanced head and neck squamous cell carcinoma (NeoRTPC02): A phase II, open-label, single-arm trial.

Journal of Clinical Oncology2025-05-28

Neoadjuvant with low-dose radiotherapy, tislelizumab, albumin-bound paclitaxel, and cisplatin for resectable locally advanced head and neck squamous cell carcinoma: phase II single-arm trial

Nature Communications2025-05-178 citations

Low-dose moderate hypofractionated radiotherapy for indolent non-Hodgkin lymphoma: a multicentre, single-arm, phase 2 trial.

2025-05-02

Multicenter Phase Ii Study of Moderate Low-Dose Radiotherapy in Indolent Non-Hodgkin Lymphoma: CLCG-iNHL-01 Protocol

Future Oncology2024-01-014 citations

Neoadjuvant low-dose radiotherapy, tislelizumab, combined with albumin-bound paclitaxel and cisplatin in resectable locally advanced head and neck squamous cell carcinoma (NeoRTPC02): The first-stage result from an open label, single-arm, two stage, phase II clinical trial.

Journal of Clinical Oncology2023-06-01

Low-dose fractionated radiotherapy combined with neoadjuvant chemotherapy for T3-4 nasopharyngeal carcinoma patients: Preliminary results of a phase II randomized controlled trial.

Journal of Clinical Oncology2023-06-01

SARS-CoV-2 Serum Viral Load and Prognostic Markers Proposal for COVID-19 Pneumonia in Low-Dose Radiation Therapy Treated Patients

Journal of Clinical Medicine2023-01-195 citations

Effect of Low-Dose Radiotherapy on the Circulating Levels of Paraoxonase-1-Related Variables and Markers of Inflammation in Patients with COVID-19 Pneumonia

Antioxidants2022-06-1610 citations

Low dose anti-inflammatory radiotherapy for the treatment of pneumonia by covid-19: A proposal for a multi-centric prospective trial.

2020-06-1515 citations