Lopinavir / Ritonavir

DRUG12 trials

Sponsors

Oswaldo Cruz Foundation, Kirby Institute, AbbVie (prior sponsor, Abbott), UMC Utrecht, Food and Drug Administration (FDA)

Conditions

COVID-19Community-acquired Pneumonia, Influenza, COVID-19Covid19Drug-induced QT ProlongationFavipiravirHIVHIV InfectionsHigh-Grade Anal Intraepithelial Neoplasia

Phase 1

CiPA Phase 1 ECG Biomarker Validation Study

CompletedNCT03070470

Food and Drug Administration (FDA)Drug-induced QT Prolongation, Pharmacodynamics, Pharmacokinetics

Start: 2017-03-14End: 2017-06-26Updated: 2020-01-18

Lopinavir/Ritonavir in PLWH With High-Grade AIN

RecruitingNCT05334004

University of Wisconsin, MadisonHigh-Grade Anal Intraepithelial Neoplasia

Start: 2023-12-19End: 2026-06-01Target: 21Updated: 2026-02-10

LUSZ Treatment Efficacy in Hospitalized COVID-19 Patients

RecruitingNCT05925140

Lebanese UniversityCOVID-19, Hospitalized COVID-19 Patients

Start: 2020-03-28End: 2025-12-30Target: 1000Updated: 2024-02-06

Phase 2

An Investigation Into Beneficial Effects of Interferon Beta 1a, Compared to Interferon Beta 1b And The Base Therapeutic Regiment in Moderate to Severe COVID-19: A Randomized Clinical Trial

CompletedNCT04343768

Shahid Beheshti University of Medical SciencesCOVID-19

Start: 2020-04-09End: 2020-04-27Updated: 2020-05-05

Phase 3

Randomized, Embedded, Multifactorial Adaptive Platform Trial for Community- Acquired Pneumonia

RecruitingNCT02735707

UMC UtrechtCommunity-acquired Pneumonia, Influenza, COVID-19

Start: 2016-04-11End: 2028-02-29Target: 20000Updated: 2024-07-12

Phase 4

Pharmacokinetics of the Tablet Formulation of Lopinavir/r as Standard and Increased Dosage During Pregnancy

CompletedNCT00605098

Oswaldo Cruz FoundationHIV Infections, Pregnancy

Start: 2008-02-29End: 2012-07-31Updated: 2013-10-28

Bone and Body Comp: A Sub Study of the SECOND-LINE Study

CompletedNCT01513122

Kirby InstituteHIV

Start: 2010-02-28End: 2013-08-31Updated: 2025-06-26

Umifenovir in Hospitalized COVID-19 Patients

Shahid Beheshti University of Medical SciencesCOVID-19

Start: 2020-04-15End: 2020-04-24Target: 40Updated: 2020-04-20

Interferon Beta 1a in Hospitalized COVID-19 Patients

Shahid Beheshti University of Medical SciencesCOVID-19

Start: 2020-04-15End: 2020-04-24Target: 40Updated: 2020-04-20

Unknown Phase

Real-life Effectiveness of the Kaletra Adherence Support Assistance (KASA) Program

CompletedNCT01662336

AbbVie (prior sponsor, Abbott)Human Immunodeficiency Virus Infection

Start: 2012-06-30End: 2016-06-30Updated: 2018-01-29

Favipiravir Plus Hydroxychloroquine and Lopinavir/Ritonavir Plus Hydroxychloroquine in COVID-19

CompletedNCT04376814

Baqiyatallah Medical Sciences UniversityCOVID-19, Favipiravir, Hydroxychloroquine +2

Start: 2020-03-29End: 2020-05-25Updated: 2020-06-16

Public Health Emergency: SOLIDARITY TRIAL Philippines

CompletedNCT05024006

University of the PhilippinesCovid19

Start: 2020-04-23End: 2021-04-17Updated: 2022-03-02

Related Papers

Tocilizumab, sarilumab and anakinra in critically ill patients with COVID-19: a randomised, controlled, open-label, adaptive platform trial

Thorax2025-05-139 citations

Effect of hydrocortisone on mortality in patients with severe community-acquired pneumonia

Intensive Care Medicine2025-04-0132 citations

A blueprint for a multi-disease, multi-domain Bayesian adaptive platform trial incorporating adult and paediatric subgroups: the Staphylococcus aureus Network Adaptive Platform trial.

2023-12-068 citations

Simvastatin in Critically Ill Patients with Covid-19

New England Journal of Medicine2023-10-2559 citations

Intravenous Vitamin C for Patients Hospitalized With COVID-19

JAMA2023-10-2545 citations

Effect of Angiotensin-Converting Enzyme Inhibitor and Angiotensin Receptor Blocker Initiation on Organ Support–Free Days in Patients Hospitalized With COVID-19

JAMA2023-04-1166 citations

The Relationship Between SARS-CoV-2 Neutralizing Antibody Titers and Avidity in Plasma Collected From Convalescent Nonvaccinated and Vaccinated Blood Donors

The Journal of Infectious Diseases2023-03-274 citations

Heterogeneous Treatment Effects of Therapeutic-Dose Heparin in Patients Hospitalized for COVID-19

JAMA2023-03-2192 citations

The Impact of COVID-19 Research on the Development of Scalable Frameworks for Efficient Clinical Trials in Cardiovascular Medicine

Canadian Journal of Cardiology2023-03-153 citations

Clinical efficacy and safety of interleukin-6 receptor antagonists (tocilizumab and sarilumab) in patients with COVID-19: a systematic review and meta-analysis.

2022-12-0128 citations

Outcomes of Convalescent Plasma with Defined High versus Lower Neutralizing Antibody Titers against SARS-CoV-2 among Hospitalized Patients: CoronaVirus Inactivating Plasma (CoVIP) Study.

2022-09-2211 citations

Effect of Antiplatelet Therapy on Survival and Organ Support–Free Days in Critically Ill Patients With COVID-19

JAMA2022-03-22144 citations

Atorvastatin versus placebo in patients with covid-19 in intensive care: randomized controlled trial

BMJ2022-01-0779 citations

Chronic Oral Anticoagulation Therapy and Prognosis of Patients Admitted to Hospital for COVID‐19: Insights from the HOPE COVID‐19 Registry

International Journal of Clinical Practice2022-01-015 citations

Effect of Convalescent Plasma on Organ Support–Free Days in Critically Ill Patients With COVID-19

JAMA2021-10-05208 citations

Therapeutic Anticoagulation with Heparin in Noncritically Ill Patients with Covid-19.

Bristol Research (University of Bristol)2021-08-26586 citations

Therapeutic Anticoagulation with Heparin in Noncritically Ill Patients with Covid-19

New England Journal of Medicine2021-08-041046 citations

Therapeutic Anticoagulation with Heparin in Critically Ill Patients with Covid-19

New England Journal of Medicine2021-08-04947 citations

Editorial: Tocilizumab, a Humanized Therapeutic IL-6 Receptor (IL-6R) Monoclonal Antibody, and Future Combination Therapies for Severe COVID-19.

2021-07-197 citations

Umifenovir in hospitalized moderate to severe COVID-19 patients: A randomized clinical trial.

2021-07-1019 citations

12 more papers not shown