Long course chemoradiotherapy

RADIATION2 trials

Sponsors

Alliance for Clinical Trials in Oncology, Jules Bordet Institute

Conditions

Locally Advanced Rectal CancerLocally Advanced Rectal CarcinomaOlder PeopleStage II Rectal Cancer AJCC v8Stage III Rectal Cancer AJCC v8

Phase 2

Testing the Addition of an Anti-Cancer Drug, Irinotecan, to the Standard Chemotherapy Treatment (FOLFOX) After Long-Course Radiation Therapy for Advanced-Stage Rectal Cancers to Improve the Rate of Complete Response and Long-Term Rates of Organ Preservation

Active, not recruitingNCT05610163

Alliance for Clinical Trials in OncologyLocally Advanced Rectal Carcinoma, Stage III Rectal Cancer AJCC v8, Stage II Rectal Cancer AJCC v8

Start: 2022-12-08End: 2033-09-30Updated: 2025-09-08

Unknown Phase

Efficacy and Safety of Conventional Neoadjuvant Therapy Versus Total Neoadjuvant Therapy in Older Patients With Locally Advanced Rectal Cancer

RecruitingNCT06052332

Jules Bordet InstituteLocally Advanced Rectal Cancer, Older People

Start: 2024-02-07End: 2033-12-31Target: 230Updated: 2025-12-05

Related Papers

Alliance A022104/NRG-GI010, a randomized phase II/III trial testing the efficacy of triplet versus doublet chemotherapy regarding clinical complete response and disease-free survival in patients with locally advanced rectal cancer (LARC): The Janus Rectal Cancer trial.

Journal of Clinical Oncology2026-01-10

Trials in progress: Alliance A022104/NRG-GI010—A randomized phase II/III trial testing the efficacy of triplet versus doublet chemotherapy regarding clinical complete response and disease-free survival in patients with locally advanced rectal cancer (LARC; the Janus Rectal Cancer trial).

Journal of Clinical Oncology2025-05-28

No operation after short-course radiotherapy followed by consolidation chemotherapy in locally advanced rectal cancer (NOAHS-ARC): study protocol for a prospective, phase II trial.

2025-03-181 citations

Alliance A022104/NRG-GI010: The Janus Rectal Cancer Trial: a randomized phase II/III trial testing the efficacy of triplet versus doublet chemotherapy regarding clinical complete response and disease-free survival in patients with locally advanced rectal cancer.

2024-07-2621 citations

Efficacy and safety of short-course radiotherapy versus total neoadjuvant therapy in older rectal cancer patients: a randomised pragmatic trial (SHAPERS)

ESMO Gastrointestinal Oncology2024-06-012 citations

A Phase Ib Study of the DNA-PK Inhibitor Peposertib Combined with Neoadjuvant Chemoradiation in Patients with Locally Advanced Rectal Cancer

Clinical Cancer Research2023-12-0528 citations

Alliance A022104/NRG-GI010: A randomized phase II trial testing the efficacy of triplet versus doublet chemotherapy to achieve clinical complete response in patients with locally advanced rectal cancer—The Janus Rectal Cancer trial.

Journal of Clinical Oncology2023-06-0119 citations