Lofexidine HCl

DRUG6 trials

Sponsors

USWM, LLC (dba US WorldMeds)

Conditions

Acute Opioid Withdrawal SyndromeBuprenorphine Withdrawal SyndromeHealthyMethadone Withdrawal SyndromeOpioid DependenceRenally Impaired Subjects

Phase 1

Lofexidine Food Effect Study in Healthy Volunteers

CompletedNCT01437306

USWM, LLC (dba US WorldMeds)Healthy

Start: 2011-10-31End: 2011-10-31Updated: 2018-02-23

Pilot Study of Lofexidine and Methadone Pharmacodynamic Interaction in Methadone Maintained Patients

CompletedNCT01558934

USWM, LLC (dba US WorldMeds)Methadone Withdrawal Syndrome, Opioid Dependence

Start: 2012-02-29End: 2012-04-30Updated: 2018-02-23

Main Study of Lofexidine and Methadone Pharmacodynamic Interaction in Methadone Maintained Patients

CompletedNCT01650649

USWM, LLC (dba US WorldMeds)Methadone Withdrawal Syndrome, Opioid Dependence

Start: 2012-07-31End: 2012-12-31Updated: 2017-10-26

Pharmacokinetic & Pharmacodynamic Interaction of Lofexidine and Buprenorphine in Buprenorphine Maintained Patients

CompletedNCT01820442

USWM, LLC (dba US WorldMeds)Buprenorphine Withdrawal Syndrome, Opioid Dependence

Start: 2013-03-31End: 2013-09-30Updated: 2018-02-23

Single-dose Pharmacokinetics and Safety of Oral Lofexidine in Renally-Impaired Subjects

CompletedNCT02313103

USWM, LLC (dba US WorldMeds)Renally Impaired Subjects

Start: 2014-11-30End: 2015-02-28Updated: 2017-10-26

Phase 3

Efficacy, Safety and Dose-Response Study Followed by Open-Label Study of Lofexidine Treatment of Opioid Withdrawal

CompletedNCT01863186

USWM, LLC (dba US WorldMeds)Acute Opioid Withdrawal Syndrome, Opioid Dependence

Start: 2013-06-30End: 2014-12-31Updated: 2022-03-22

Related Papers

Efficacy of lofexidine for mitigating opioid withdrawal symptoms: results from two randomized, placebo-controlled trials

Journal of Drug Assessment2020-01-01170 citations

Effect of lofexidine on cardiac repolarization during treatment of opioid withdrawal.

2019-09-273 citations

Safety and Efficacy of Lofexidine for Medically Managed Opioid Withdrawal: A Randomized Controlled Clinical Trial

Journal of Addiction Medicine2018-12-1153 citations