local radiation

RADIATION2 trials

Sponsors

Robert Lowsky, CureVac

Conditions

Hodgkin DiseaseLymphoma, Non-HodgkinNon-Small Cell Lung Carcinoma

Phase 1

Immunostimulatory CpG SD-101 + RT in Recurrent/Progressive Lymphoma After Allogeneic Hematopoietic Cell Transplantation (HCT)

TerminatedNCT01745354

Robert LowskyHodgkin Disease, Lymphoma, Non-Hodgkin

Start: 2012-08-31End: 2014-11-30Updated: 2016-11-18

Trial of RNActive®-Derived Cancer Vaccine and Local Radiation in in Stage IV Non Small Cell Lung Cancer (NSCLC)

TerminatedNCT01915524

CureVacNon-Small Cell Lung Carcinoma

Start: 2013-04-30End: 2016-07-31Updated: 2016-08-05

Related Papers

Phase Ib evaluation of a self-adjuvanted protamine formulated mRNA-based active cancer immunotherapy, BI1361849 (CV9202), combined with local radiation treatment in patients with stage IV non-small cell lung cancer

Journal for ImmunoTherapy of Cancer2019-02-08213 citations

Activity of a Sting and a TLR9 Agonist As an “in Situ Therapeutic Vaccination” Against Lymphomas

Blood2016-12-021 citations

Phase Ib trial of the RNActive cancer vaccine BI 1361849 (CV9202) and local radiotherapy (RT) in patients (pts) with stage IV NSCLC with disease control after 1st-line chemotherapy or during therapy with an EGFR-TKI: results of an interim analysis.

Journal of Clinical Oncology2016-05-202 citations

Dose-Escalated, Intratumoral TLR9 Agonist and Low-Dose Radiation Induce Abscopal Effects in Follicular Lymphoma

Blood2014-12-0612 citations

Phase Ib study evaluating a self-adjuvanted mRNA cancer vaccine (RNActive®) combined with local radiation as consolidation and maintenance treatment for patients with stage IV non-small cell lung cancer.

2014-10-06105 citations