LNP023
Sponsors
Novartis Pharma AG, Novartis Pharmaceuticals
Conditions
+/- VC3 GlomerulopathyGlomerulonephritisIdiopathic Membranous NephropathyIgA NephropathyImmune-complex-membranoproliferative GlomerulonephritisLupus Nephritis Class III-IVParoxysmal Nocturnal Hemoglobinuria
Phase 2
Proof of Concept Study to Assess the Efficacy, Safety and Pharmacokinetics of LFG316 in Patients With Paroxysmal Nocturnal Hemoglobinuria
CompletedNCT02534909
Start: 2015-09-09End: 2022-05-24Updated: 2025-05-16
Study of Safety and Efficacy of LNP023 in Patients With Kidney Disease Caused by Inflammation
CompletedNCT03373461
Start: 2018-02-07End: 2021-06-22Updated: 2023-01-30
Study on Efficacy and Safety of LNP023 in C3 Glomerulopathy Patients Transplanted and Not Transplanted
CompletedNCT03832114
Start: 2019-02-20End: 2021-04-23Updated: 2024-01-30
Efficacy, Safety, Pharmacokinetics and Pharmacodynamics Study, Assessing Multiple LNP023 Doses in Adult Patients With Paroxysmal Nocturnal Hemoglobinuria
CompletedNCT03896152
Start: 2019-04-05End: 2022-02-09Updated: 2024-06-18
Efficacy and Safety of LNP023 Compared With Rituximab in Subjects With Idiopathic Membranous Nephropathy
TerminatedNCT04154787
Start: 2019-11-23End: 2023-01-20Updated: 2024-10-09
An adaptive, randomized, double-blind, dose exploration, parallel group, placebo controlled, multicenter phase 2 trial to evaluate the efficacy, safety and tolerability of LNP023 in combination with standard-of-care with and without oral corticosteroids in adult patients with active lupus nephritis Class III-IV, +/- V
RecruitingCTIS2023-509332-26-00
Start: 2023-02-16Target: 48Updated: 2025-12-30
Phase 3
Long-term Efficacy, Safety and Tolerability of Iptacopan in C3G or IC-MPGN
RecruitingNCT03955445
Start: 2019-10-03End: 2036-05-30Target: 225Updated: 2026-02-23
A Rollover Extension Program (REP) to Evaluate the Long-term Safety and Tolerability of Open Label Iptacopan/LNP023 in Participants With Primary IgA Nephropathy
RecruitingNCT04557462
Start: 2021-09-20End: 2032-10-25Target: 540Updated: 2026-02-23
Study of Efficacy and Safety of Twice Daily Oral LNP023 in Adult PNH Patients With Residual Anemia Despite Anti-C5 Antibody Treatment
CompletedNCT04558918
Start: 2021-01-25End: 2023-03-06Updated: 2024-10-09
Study of Efficacy and Safety of LNP023 in Primary IgA Nephropathy Patients
CompletedNCT04578834
Start: 2021-01-25End: 2025-09-19Updated: 2025-12-23
An open label, multicenter roll-over extension program (REP) to
characterize the long-term safety and tolerability of iptacopan (LNP023) in
patients with Paroxysmal Nocturnal Hemoglobinuria (PNH) who have
completed PNH Phase 2 and Phase 3 studies with iptacopan.
Active, not recruitingCTIS2023-509843-28-00
Start: 2021-11-10Target: 86Updated: 2026-01-26
Study to Assess the Pharmacokinetics, Safety, and Tolerability of Iptacopan in Pediatric PNH Patients
RecruitingNCT06934967
Start: 2025-10-28End: 2031-12-19Target: 12Updated: 2025-12-23
Unknown Phase
Related Papers
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