LN-145-S1

BIOLOGICAL2 trials

Sponsors

Iovance Biotherapeutics, Inc.

Conditions

Metastatic MelanomaNon-small Cell Lung CancerSquamous Cell Carcinoma of the Head and Neck

Phase 2

Study of LN-145/LN-145-S1 Autologous Tumor Infiltrating Lymphocytes in the Treatment of Squamous Cell Carcinoma of the Head & Neck

CompletedNCT03083873

Iovance Biotherapeutics, Inc.Squamous Cell Carcinoma of the Head and Neck

Start: 2017-01-09End: 2022-08-08Updated: 2023-10-12

Study of Autologous Tumor Infiltrating Lymphocytes in Patients With Solid Tumors

RecruitingNCT03645928

Iovance Biotherapeutics, Inc.Metastatic Melanoma, Non-small Cell Lung Cancer, Squamous Cell Carcinoma of the Head and Neck

Start: 2019-05-07End: 2029-08-09Target: 245Updated: 2025-06-19

Related Papers

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492 Phase 2 efficacy and safety of autologous tumor-infiltrating lymphocyte (TIL) cell therapy in combination with pembrolizumab in immune checkpoint inhibitor-naïve patients with advanced cancers

Regular and Young Investigator Award Abstracts2021-11-0134 citations

458 First phase 2 results of autologous tumor-infiltrating lymphocyte (TIL; LN-145) monotherapy in patients with advanced, immune checkpoint inhibitor-treated, non-small cell lung cancer (NSCLC)

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Abstract CT235: A Phase 2, multicenter study of autologous tumor infiltrating lymphocytes (TIL, LN 144/LN-145/LN-145-S1) in patients with solid tumors

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353 Safety and efficacy of tumor infiltrating lymphocytes (TIL, LN-145) in combination with pembrolizumab for advanced, recurrent or metastatic HNSCC

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Future role for adoptive T-cell therapy in checkpoint inhibitor-resistant metastatic melanoma

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A phase II study of autologous tumor infiltrating lymphocytes (TIL, LN-144/LN-145) in patients with solid tumors.

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A phase II study of autologous tumor infiltrating lymphocytes (TIL; LN-144/LN-145) in patients with solid tumors

Annals of Oncology2018-12-01

Abstract CT170: A phase II, multicenter study to evaluate the efficacy and safety of autologous tumor infiltrating lymphocytes (LN-145) for the treatment of patients with recurrent and/or metastatic squamous cell carcinoma of the head and neck

Cancer Research2018-07-011 citations

A phase 2, multicenter study to evaluate the efficacy and safety of autologous tumor infiltrating lymphocytes (LN-145) for the treatment of patients with recurrent and/or metastatic squamous cell carcinoma of the head and neck (HNSCC).

Journal of Clinical Oncology2018-05-2011 citations