LMB-100
Sponsors
National Cancer Institute (NCI)
Conditions
Adenocarcinoma of LungAdenocarcinoma, PancreaticCholangiocarcinoma, ExtrahepaticEpithelial Tumors, MalignantEpithelioid MesotheliomaLung CancerMalignant Pleural Effusions (Mpe)Malignant Pleural Mesotheliomas (Mpm)
Phase 1
Mesothelin-Targeted Immunotoxin LMB-100 in People With Malignant Mesothelioma
CompletedNCT02798536
Start: 2016-07-27End: 2022-04-21Updated: 2022-08-23
Mesothelin-Targeted Immunotoxin LMB-100 Alone or in Combination With Nab-Paclitaxel in People With Previously Treated Metastatic and/or Locally Advanced Pancreatic Ductal Adenocarcinoma and Mesothelin Expressing Solid Tumors
CompletedNCT02810418
Start: 2016-08-03End: 2021-06-22Updated: 2022-03-15
Mesothelin-Targeted Immunotoxin LMB-100 in Combination With SEL-110 in Subjects With Malignant Pleural or Peritoneal Mesothelioma
TerminatedNCT03436732
Start: 2018-02-28End: 2019-04-30Updated: 2019-11-22
Mesothelin-Targeted Immunotoxin LMB-100 in Combination With Tofacitinib in Persons With Previously Treated Pancreatic Adenocarcinoma, Cholangiocarcinoma and Other Mesothelin Expressing Solid Tumors
CompletedNCT04034238
Start: 2019-08-29End: 2021-11-19Updated: 2023-08-01
Intratumor Injection of Anti-Mesothelin Immunotoxin LMB-100 With Ipilimumab in Malignant Mesothelioma
TerminatedNCT04840615
Start: 2021-06-11End: 2022-01-12Updated: 2024-02-02
Phase I Evaluation of Immunotoxin LMB-100 Administered by Normothermic, Intrapleural Perfusion Following Cytoreductive Surgery in Participants With Pleural Mesotheliomas, or Pleural Effusions From Cancers Expressing Mesothelin
WithdrawnNCT05375825
Start: 2024-01-31End: 2024-01-31Updated: 2024-02-02
Phase 2
Anti-Mesothelin Immunotoxin LMB-100 Followed by Pembrolizumab in Malignant Mesothelioma
TerminatedNCT03644550
Start: 2018-12-04End: 2020-11-02Updated: 2021-12-02
LMB-100 Followed by Pembrolizumab in the Treatment of Adults With Mesothelin-Expressing Non-Squamous Non-Small Cell Lung Cancer (NSCLC)
TerminatedNCT04027946
Start: 2019-09-11End: 2023-12-22Updated: 2024-04-16