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LMB-100

DRUG8 trials

Sponsors

National Cancer Institute (NCI)

Conditions

Adenocarcinoma of LungAdenocarcinoma, PancreaticCholangiocarcinoma, ExtrahepaticEpithelial Tumors, MalignantEpithelioid MesotheliomaLung CancerMalignant Pleural Effusions (Mpe)Malignant Pleural Mesotheliomas (Mpm)

Phase 1

Mesothelin-Targeted Immunotoxin LMB-100 in People With Malignant Mesothelioma
CompletedNCT02798536
National Cancer Institute (NCI)Mesothelioma
Start: 2016-07-27End: 2022-04-21Updated: 2022-08-23
Mesothelin-Targeted Immunotoxin LMB-100 Alone or in Combination With Nab-Paclitaxel in People With Previously Treated Metastatic and/or Locally Advanced Pancreatic Ductal Adenocarcinoma and Mesothelin Expressing Solid Tumors
CompletedNCT02810418
National Cancer Institute (NCI)Neoplasms, Pancreatic Neoplasms
Start: 2016-08-03End: 2021-06-22Updated: 2022-03-15
Mesothelin-Targeted Immunotoxin LMB-100 in Combination With SEL-110 in Subjects With Malignant Pleural or Peritoneal Mesothelioma
TerminatedNCT03436732
National Cancer Institute (NCI)Mesothelioma
Start: 2018-02-28End: 2019-04-30Updated: 2019-11-22
Mesothelin-Targeted Immunotoxin LMB-100 in Combination With Tofacitinib in Persons With Previously Treated Pancreatic Adenocarcinoma, Cholangiocarcinoma and Other Mesothelin Expressing Solid Tumors
CompletedNCT04034238
National Cancer Institute (NCI)Adenocarcinoma, Pancreatic, Cholangiocarcinoma, Extrahepatic, Epithelioid Mesothelioma +1
Start: 2019-08-29End: 2021-11-19Updated: 2023-08-01
Intratumor Injection of Anti-Mesothelin Immunotoxin LMB-100 With Ipilimumab in Malignant Mesothelioma
TerminatedNCT04840615
National Cancer Institute (NCI)Mesothelioma
Start: 2021-06-11End: 2022-01-12Updated: 2024-02-02
Phase I Evaluation of Immunotoxin LMB-100 Administered by Normothermic, Intrapleural Perfusion Following Cytoreductive Surgery in Participants With Pleural Mesotheliomas, or Pleural Effusions From Cancers Expressing Mesothelin
WithdrawnNCT05375825
National Cancer Institute (NCI)Epithelial Tumors, Malignant, Malignant Pleural Effusions (Mpe), Malignant Pleural Mesotheliomas (Mpm) +2
Start: 2024-01-31End: 2024-01-31Updated: 2024-02-02

Phase 2

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