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Livmoniplimab

DRUG11 trials

Sponsors

Abbvie Deutschland GmbH & Co. KG, AbbVie Deutschland GmbH & Co. KG, AbbVie

Conditions

Advanced Solid Tumors CancerHepatocellular CarcinomaHepatocellular Carcinoma (HCC)Locally Advanced or Metastatic Solid TumorsMetastatic Hepatocellular Carcinoma (HCC)Metastatic Urothelial CarcinomaNon-Small Cell Lung CancerSolid Tumors

Phase 1

Phase 2

Study to Evaluate Adverse Events, and Change in Disease Activity, When Intravenously (IV) Infused With Livmoniplimab in Combination With IV Infused Budigalimab in Adult Participants With Hepatocellular Carcinoma (HCC)
Active, not recruitingNCT05822752
AbbVieHepatocellular Carcinoma
Start: 2023-09-21End: 2026-11-30Updated: 2025-08-14
A Study to Assess the Dose, Adverse Events, and Change in Disease Activity of Livmoniplimab as an Intravenous (IV) Solution in Combination With Budigalimab as an IV Solution in Adult Participants With Hepatocellular Carcinoma (HCC)
RecruitingNCT06109272
AbbVieHepatocellular Carcinoma
Start: 2024-01-11End: 2030-09-30Target: 660Updated: 2025-08-15
A Phase 2, Randomized Study to Evaluate the Optimized Dose, Safety, and Efficacy of Livmoniplimab in Combination with Budigalimab for locally advanced or Metastatic Hepatocellular Carcinoma patients who have progressed after an approved immune checkpoint inhibitor containing regimen in First-Line HCC
Active, not recruitingCTIS2022-502948-13-00
Abbvie Deutschland GmbH & Co. KGHepatocellular Carcinoma
Start: 2024-03-01Target: 63Updated: 2025-12-04
Study to Evaluate Adverse Events, Optimal Dose, and Change in Disease Activity, With Livmoniplimab in Combination With Budigalimab Plus Chemotherapy Versus IV Infused Pembrolizumab Plus Chemotherapy in Adult Participants With Untreated Metastatic Non-Squamous Non-Small Cell Lung Cancer (NSCLC)
RecruitingNCT06236438
AbbVieNon-Small Cell Lung Cancer
Start: 2024-04-10End: 2031-10-01Target: 840Updated: 2026-02-23
A Phase 2/3, Randomized Study to Evaluate the Optimized dose, Safety, and Efficacy of Livmoniplimab in Combination with Budigalimab in Subjects with Locally Advanced or Metastatic Hepatocellular Carcinoma (HCC) who have not previously received systemic treatment
RecruitingCTIS2023-504600-28-00
AbbVie Deutschland GmbH & Co. KGMetastatic Hepatocellular Carcinoma (HCC)
Start: 2024-05-09Target: 40Updated: 2025-11-17
A Randomized, Phase 2/3 Study to Evaluate the Optimal Dose, Safety, and Efficacy of Livmoniplimab in Combination with Budigalimab Plus Chemotherapy Versus Pembrolizumab Plus Chemotherapy in Untreated Metastatic Non-Squamous Non-Small Cell Lung Cancer (NSCLC) – LIVIGNO-4
RecruitingCTIS2023-505773-32-00
AbbVie Deutschland GmbH & Co. KGUntreated Metastatic Non-Squamous Non-Small Cell Lung Cancer
Start: 2025-03-25Target: 57Updated: 2025-11-21
Study to Evaluate Adverse Events and Change in Disease Activity When Intravenously (IV) Infused Livmoniplimab is Used in Combination With IV Infused Budigalimab in Adult Participants With Urothelial Carcinoma (UC)
Active, not recruitingNCT06632951
AbbVieUrothelial Carcinoma
Start: 2025-01-20End: 2028-08-31Target: 150Updated: 2025-08-11
A Phase 2, Open-Label, Randomized Study of Livmoniplimab in Combination with Budigalimab Versus Chemotherapy in Subjects with Metastatic Urothelial Carcinoma
RecruitingCTIS2024-515506-11-00
AbbVie Deutschland GmbH & Co. KGMetastatic Urothelial Carcinoma, Urothelial Carcinoma
Start: 2025-03-24Target: 60Updated: 2025-12-09

Related Papers

Molecular Therapy — Oncolytics2023-12-0127 citations