Livmoniplimab
Sponsors
Abbvie Deutschland GmbH & Co. KG, AbbVie Deutschland GmbH & Co. KG, AbbVie
Conditions
Advanced Solid Tumors CancerHepatocellular CarcinomaHepatocellular Carcinoma (HCC)Locally Advanced or Metastatic Solid TumorsMetastatic Hepatocellular Carcinoma (HCC)Metastatic Urothelial CarcinomaNon-Small Cell Lung CancerSolid Tumors
Phase 1
Study to Determine the Safety, Tolerability, Pharmacokinetics and Recommended Phase 2 Dose (RP2D) of Livmoniplimab (ABBV-151) as a Single Agent and in Combination With Budigalimab (ABBV-181) in Participants With Locally Advanced or Metastatic Solid Tumors
Active, not recruitingNCT03821935
Start: 2019-02-21End: 2027-06-30Updated: 2025-05-25
A Phase 1 First-in Human, Multi-Center, Open Label Dose-Escalation Study to Determine the Safety, Tolerability, Pharmacokinetics and RP2D of ABBV-151 as a Single Agent and in Combination with ABBV-181 in Subjects with Locally Advanced or Metastatic Solid Tumors
Active, not recruitingCTIS2023-508281-15-00
Start: 2020-11-10Target: 120Updated: 2025-12-03
A Study to Assess the Adverse Events and How Intravenously Infused Livmoniplimab in Combination With Budigalimab Moves Through the Bodies of Adult Chinese Participants With Locally Advanced or Metastatic Hepatocellular Carcinoma (HCC)
RecruitingNCT06487559
Start: 2024-09-11End: 2027-10-31Target: 20Updated: 2025-03-04
Phase 2
Study to Evaluate Adverse Events, and Change in Disease Activity, When Intravenously (IV) Infused With Livmoniplimab in Combination With IV Infused Budigalimab in Adult Participants With Hepatocellular Carcinoma (HCC)
Active, not recruitingNCT05822752
Start: 2023-09-21End: 2026-11-30Updated: 2025-08-14
A Study to Assess the Dose, Adverse Events, and Change in Disease Activity of Livmoniplimab as an Intravenous (IV) Solution in Combination With Budigalimab as an IV Solution in Adult Participants With Hepatocellular Carcinoma (HCC)
RecruitingNCT06109272
Start: 2024-01-11End: 2030-09-30Target: 660Updated: 2025-08-15
A Phase 2, Randomized Study to Evaluate the Optimized Dose, Safety, and Efficacy of Livmoniplimab in Combination with Budigalimab for locally advanced or Metastatic Hepatocellular Carcinoma patients who have progressed after an approved immune checkpoint inhibitor containing regimen in First-Line HCC
Active, not recruitingCTIS2022-502948-13-00
Start: 2024-03-01Target: 63Updated: 2025-12-04
Study to Evaluate Adverse Events, Optimal Dose, and Change in Disease Activity, With Livmoniplimab in Combination With Budigalimab Plus Chemotherapy Versus IV Infused Pembrolizumab Plus Chemotherapy in Adult Participants With Untreated Metastatic Non-Squamous Non-Small Cell Lung Cancer (NSCLC)
RecruitingNCT06236438
Start: 2024-04-10End: 2031-10-01Target: 840Updated: 2026-02-23
A Phase 2/3, Randomized Study to Evaluate the Optimized dose, Safety, and Efficacy of Livmoniplimab in Combination with Budigalimab in Subjects with Locally Advanced or Metastatic Hepatocellular Carcinoma (HCC) who have not previously received systemic treatment
RecruitingCTIS2023-504600-28-00
Start: 2024-05-09Target: 40Updated: 2025-11-17
A Randomized, Phase 2/3 Study to Evaluate the Optimal Dose, Safety, and Efficacy of Livmoniplimab in Combination with Budigalimab Plus Chemotherapy Versus Pembrolizumab Plus Chemotherapy in Untreated Metastatic Non-Squamous Non-Small Cell Lung Cancer (NSCLC) – LIVIGNO-4
RecruitingCTIS2023-505773-32-00
Start: 2025-03-25Target: 57Updated: 2025-11-21
Study to Evaluate Adverse Events and Change in Disease Activity When Intravenously (IV) Infused Livmoniplimab is Used in Combination With IV Infused Budigalimab in Adult Participants With Urothelial Carcinoma (UC)
Active, not recruitingNCT06632951
Start: 2025-01-20End: 2028-08-31Target: 150Updated: 2025-08-11
A Phase 2, Open-Label, Randomized Study of Livmoniplimab in Combination with Budigalimab Versus Chemotherapy in Subjects with Metastatic Urothelial Carcinoma
RecruitingCTIS2024-515506-11-00
Start: 2025-03-24Target: 60Updated: 2025-12-09