Lisaftoclax
Sponsors
Ascentage Pharma Group Inc., The First Affiliated Hospital of Soochow University, Sun Yat-sen University, M.D. Anderson Cancer Center, Henan Cancer Hospital
Conditions
Acute myeloid leukemiaCLL / SLLCLL/SLLChronic Lymphocytic Leukemia/Small Lymphocytic LymphomaDLBCL - Diffuse Large B Cell LymphomaDiffuse Large B Cell Lymphoma (DLBCL)FLAG ChemotherapyIndolent Lymphoma
Phase 1
Study of APG-2575 as a Single Agent or in Combination With Other Therapeutic Agents for CLL/SLL
RecruitingNCT04215809
Start: 2020-03-02End: 2027-06-30Target: 144Updated: 2025-04-10
A Phase Ib/II Study of APG-2575 as a Single Agent or in Combination with Other Therapeutic Agents in Patients with Relapsed and/or Refractory Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL) (SACRED).
RecruitingCTIS2024-515654-25-00
Start: 2021-12-20Target: 60Updated: 2025-09-08
Lisatoclax Plus R-CHOP or Pola-R-CHP in Untreated DLBCL: A Phase Ib/II Study
Not yet recruitingNCT07398638
Start: 2026-02-28End: 2031-02-28Target: 122Updated: 2026-02-10
A Phase 1 Study Of FLAG Chemotherapy In Combination With Lisaftoclax And Pelcitoclax In Patients With Relapsed/Refractory T-Cell Acute Lymphoblastic Leukemia
Not yet recruitingNCT07428486
Start: 2026-08-17End: 2032-06-12Target: 24Updated: 2026-02-23
Phase 2
Pirtobrutinib, Lisaftoclax, and Rituximab in the Treatment of R/R DLBCL
RecruitingNCT07255963
Start: 2025-11-30End: 2030-09-30Target: 29Updated: 2025-12-01
Efficacy and Safety of Lisaftoclax (APG-2575) Monotherapy in Patients With Indolent Lymphoma
Not yet recruitingNCT07459608
Start: 2026-03-10End: 2028-03-01Target: 75Updated: 2026-03-13
Phase 3
A Global Multicenter, Open Label, Randomized Phase 3 Registrational Study of Lisaftoclax (APG-2575) in Previously Treated Patients with Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (GLORA Study)
RecruitingCTIS2023-508005-24-00
Start: 2024-08-01Target: 232Updated: 2025-12-03
A Global Multicenter, Open Label, Randomized Phase III Confirmatory Study of Lisaftoclax (APG-2575) in Combination with Acalabrutinib versus Immunochemotherapy in Patients with Newly Diagnosed Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (GLORA-2 Study)
RecruitingCTIS2024-514084-26-00
Start: 2025-08-22Target: 29Updated: 2025-07-31
A Global Multicenter, Double-Blind, Randomized, Registrational Phase 3 Study of Lisaftoclax (APG-2575) in Combination with Azacitidine (AZA) in Patients with Newly Diagnosed Higher Risk Myelodysplastic Syndrome (HR-MDS) (GLORA-4)
RecruitingCTIS2024-517247-31-00
Start: 2025-07-07Target: 371Updated: 2026-01-16
An international, multicenter, randomized, double-blind, phase 3 pivotal registrational clinical study of APG-2575 (Lisaftoclax) combined with azacitidine in elderly patients with newly diagnosed acute myeloid leukemia
(GLORA-3)
Not yet recruitingCTIS2024-516436-10-00
Target: 58Updated: 2025-10-26