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Lisaftoclax

DRUG10 trials

Sponsors

Ascentage Pharma Group Inc., The First Affiliated Hospital of Soochow University, Sun Yat-sen University, M.D. Anderson Cancer Center, Henan Cancer Hospital

Conditions

Acute myeloid leukemiaCLL / SLLCLL/SLLChronic Lymphocytic Leukemia/Small Lymphocytic LymphomaDLBCL - Diffuse Large B Cell LymphomaDiffuse Large B Cell Lymphoma (DLBCL)FLAG ChemotherapyIndolent Lymphoma

Phase 1

Phase 2

Phase 3

A Global Multicenter, Open Label, Randomized Phase 3 Registrational Study of Lisaftoclax (APG-2575) in Previously Treated Patients with Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (GLORA Study)
RecruitingCTIS2023-508005-24-00
Ascentage Pharma Group Inc.Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma
Start: 2024-08-01Target: 232Updated: 2025-12-03
A Global Multicenter, Open Label, Randomized Phase III Confirmatory Study of Lisaftoclax (APG-2575) in Combination with Acalabrutinib versus Immunochemotherapy in Patients with Newly Diagnosed Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (GLORA-2 Study)
RecruitingCTIS2024-514084-26-00
Ascentage Pharma Group Inc.Newly Diagnosed Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma
Start: 2025-08-22Target: 29Updated: 2025-07-31
A Global Multicenter, Double-Blind, Randomized, Registrational Phase 3 Study of Lisaftoclax (APG-2575) in Combination with Azacitidine (AZA) in Patients with Newly Diagnosed Higher Risk Myelodysplastic Syndrome (HR-MDS) (GLORA-4)
RecruitingCTIS2024-517247-31-00
Ascentage Pharma Group Inc.Newly Diagnosed Higher Risk Myelodysplastic Syndrome
Start: 2025-07-07Target: 371Updated: 2026-01-16
An international, multicenter, randomized, double-blind, phase 3 pivotal registrational clinical study of APG-2575 (Lisaftoclax) combined with azacitidine in elderly patients with newly diagnosed acute myeloid leukemia (GLORA-3)
Not yet recruitingCTIS2024-516436-10-00
Ascentage Pharma Group Inc.Acute myeloid leukemia
Target: 58Updated: 2025-10-26

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