Lipopolysaccharide

DRUG13 trials

Sponsors

Radboud University Medical Center, Boehringer Ingelheim, Bernd Jilma, Laureate Institute for Brain Research, Inc., GlaxoSmithKline

Conditions

Abdominal CancerArthritis, RheumatoidAutoimmune DiseasesEndotoxemiaHealthyHealthy VolunteersHyperoxiaHypoxia

Phase 1

Effects of Oxygen Status on Endotoxemia Induced Inflammation and Hypoxia Inducible Factor-1α

CompletedNCT01978158

Radboud University Medical CenterHyperoxia, Hypoxia, Normoxia

Start: 2013-10-31End: 2013-12-31Updated: 2015-05-20

Effect of Single Oral Dose BIRB 796 BS on Endotoxin-induced Inflammatory Responses in Healthy Human Subjects

CompletedNCT02211170

Boehringer IngelheimHealthy

Start: 2000-02-29Updated: 2014-08-07

Lipopolysaccharide (LPS) Challenge in Depression

CompletedNCT03142919

Laureate Institute for Brain Research, Inc.Major Depressive Disorder

Start: 2017-09-07End: 2020-12-01Updated: 2025-07-02

Lipopolysaccharide (LPS) or Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) Challenge Study on Healthy Subjects

CompletedNCT03306589

GlaxoSmithKlineArthritis, Rheumatoid

Start: 2017-08-11End: 2018-06-20Updated: 2019-08-08

Neuroimmune Response to Lipopolysaccharide

CompletedNCT04233593

Yale UniversityHealthy

Start: 2014-03-25End: 2021-08-17Updated: 2022-07-19

Imaging the Neuroimmune System in PTSD

CompletedNCT04236986

Yale UniversityPost Traumatic Stress Disorder

Start: 2017-03-28End: 2023-05-30Updated: 2024-12-09

Feasibility Study of Intra-Tumoral Lipopolysaccharide Immunotherapy for Intra-Abdominal

CompletedNCT05751837

Patrick Wagner, MD, FACSAbdominal Cancer, Malignancy

Start: 2023-03-16End: 2024-05-30Updated: 2024-12-10

Phase 4

Defibrotide in the Human Endotoxemia Model --- an Exploratory Trial Investigating the Effects and the Mechanisms of Defibrotide

CompletedNCT02876601

Bernd JilmaEndotoxemia, Healthy Volunteers

Start: 2017-04-18End: 2018-02-12Updated: 2019-12-19

Unknown Phase

The Effects of Concentration/Meditation on the Innate Immune Response During Human Endotoxemia

CompletedNCT01352871

Radboud University Medical CenterInnate Immune Response

Start: 2011-03-31End: 2011-05-31Target: 1Updated: 2011-06-07

Concentration/Meditation Limits Inflammation

CompletedNCT01835457

Radboud University Medical CenterAutoimmune Diseases

Start: 2013-02-28End: 2013-07-31Target: 30Updated: 2013-07-23

Inflammation and Brain Function - Pilot Study

CompletedNCT03551080

Karolinska InstitutetSickness Behavior

Start: 2009-10-31End: 2009-12-31Updated: 2018-06-11

Intradermal LPS and Antibiotics

CompletedNCT03779360

Centre for Human Drug Research, NetherlandsInflammation; Skin

Start: 2018-10-12End: 2019-02-23Updated: 2021-08-03

Molecular Imaging of Inflammation in Parkinson's Disease Using LPS and TSPO-PET/MR

RecruitingNCT05205291

University of ExeterNeurodegenerative Diseases, Parkinson Disease, REM Sleep Behavior Disorder (iRBD)

Start: 2022-02-28End: 2026-08-31Target: 30Updated: 2025-10-07

Related Papers

Intra-tumoral immunomodulatory therapy for advanced abdominal cancers using lipopolysaccharide: The Regional Immuno-Oncology Trial-1 (RIOT-1) protocol (NCT05751837)

Surgical Oncology Insight2024-03-303 citations