Liothyronine

DRUG14 trials

Sponsors

Patrice Perron, M.D. Anderson Cancer Center, Jens Faber, University of Pennsylvania, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Conditions

Abnormal Glucose MetabolismBiomarkersBrain TumorDiabetes MellitusEndocrine System DiseasesHealthyHeart FailureHeart Failure With Preserved Ejection Fraction

Early Phase 1

Inducing a Hypothyroxinemic State in Patients With Recurrent Glioblastoma or Gliosarcoma

WithdrawnNCT05017610

Emory UniversityRecurrent Glioblastoma, Recurrent Gliosarcoma

Start: 2021-10-20End: 2022-10-14Updated: 2022-12-02

Phase 1

Open-label Study of Liothyronine in MS

CompletedNCT02506751

Johns Hopkins UniversityMultiple Sclerosis, Primary Progressive, Multiple Sclerosis, Relapsing-Remitting, Multiple Sclerosis, Secondary Progressive

Start: 2015-07-31End: 2017-09-18Updated: 2018-02-12

Effects of Liothyronine on Energy Expenditure and Cardiovascular Function

CompletedNCT03098433

Virginia Commonwealth UniversityHealthy

Start: 2017-10-20End: 2019-06-24Updated: 2021-03-26

Developing Oral LT3 Therapy for Heart Failure - HFpEF

CompletedNCT04111536

University of PennsylvaniaHeart Failure With Preserved Ejection Fraction, Low Triiodothyronine Syndrome

Start: 2020-03-08End: 2023-10-31Updated: 2025-01-08

Developing Oral LT3 Therapy for Heart Failure - HFrEF

CompletedNCT04112316

University of PennsylvaniaHeart Failure With Reduced Ejection Fraction (HFrEF), Low T3 Syndrome

Start: 2020-02-11End: 2023-10-31Updated: 2024-12-24

Phase 2

Thyroid Hormone to Induce Non-Insulin Mediated Glucose Disposal in People With Insulin Receptor Mutations

CompletedNCT02457897

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)Abnormal Glucose Metabolism, Diabetes Mellitus, Insulin Resistance

Start: 2015-04-17End: 2018-09-18Updated: 2019-12-05

Combined Replacement Therapy With Levothyroxine and Liothyronine in Thyroidectomized Patients

CompletedNCT03053115

Azienda USL ModenaHypothyroidism

Start: 2017-03-14End: 2022-06-30Updated: 2023-04-21

Identification of Non-responders to Levothyroxine Therapy

CompletedNCT03627611

Oslo University HospitalBiomarkers, Endocrine System Diseases, Hypothyroidism

Start: 2018-08-14End: 2020-06-22Updated: 2021-03-17

131I-Omburtamab, in Recurrent Medulloblastoma and Ependymoma

Active, not recruitingNCT04743661

Pediatric Brain Tumor ConsortiumRecurrent Ependymoma, Recurrent Medulloblastoma

Start: 2022-04-04End: 2027-09-30Target: 62Updated: 2026-02-05

Energy Metabolism in Thyroidectomized Patients

CompletedNCT04782856

Virginia Commonwealth UniversityHypothyroidism, Thyroid Cancer, Thyroid Goiter

Start: 2020-10-28End: 2023-04-19Updated: 2024-06-14

Unknown Phase

Evaluation Study of L-T3 Utility in the Follow-up of Patients With Thyroid Cancer

CompletedNCT00223158

Patrice PerronThyroid Cancer

Start: 2003-09-30End: 2005-05-31Target: 70Updated: 2014-04-09

Combined Levothyroxine/Liothyronine Supplementation in Hypothyroid Patients With Brain Tumors

TerminatedNCT00488644

M.D. Anderson Cancer CenterBrain Tumor, Hypothyroidism

Start: 2006-02-28End: 2010-03-31Updated: 2013-06-24

Liothyronine and Heart Failure. The Long Term Effect of Liothyronine on Left Ventricular Ejection Fraction (LVEF)

CompletedNCT01481402

Jens FaberHeart Failure, Low T3 Syndrome

Start: 2011-07-31End: 2014-02-28Updated: 2019-07-16

Mechanistic Study of Subclinical Hypothyroidism In the Elderly

CompletedNCT02399475

University of PennsylvaniaSubclinical Hypothyroidism

Start: 2015-01-01End: 2019-09-30Updated: 2021-03-09

Related Papers

A feasibility double-blind trial of levothyroxine vs. levothyroxine-liothyronine in postsurgical hypothyroidism

Frontiers in Endocrinology2025-03-105 citations

Thyroid Signaling Biomarkers in Female Symptomatic Hypothyroid Patients on Liothyronine versus Levothyroxine Monotherapy: A Randomized Crossover Trial

Journal of Thyroid Research2022-05-047 citations

Acute Effects of Liothyronine Administration on Cardiovascular System and Energy Metabolism in Healthy Volunteers

Frontiers in Endocrinology2022-02-284 citations

Effect of Liothyronine Treatment on Quality of Life in Female Hypothyroid Patients With Residual Symptoms on Levothyroxine Therapy: A Randomized Crossover Study

Frontiers in Endocrinology2022-02-2220 citations

Effect of Liothyronine Treatment on Dermal Temperature and Activation of Brown Adipose Tissue in Female Hypothyroid Patients: A Randomized Crossover Study

Frontiers in Endocrinology2021-11-196 citations

Free fatty acid processing diverges in human pathologic insulin resistance conditions

Journal of Clinical Investigation2020-03-1956 citations

Thyroid Hormone Effects on Glucose Disposal in Patients With Insulin Receptor Mutations

The Journal of Clinical Endocrinology & Metabolism2019-10-0714 citations

Oligodendroglial Lineage Cells in Thyroid Hormone-Deprived Conditions.

2019-04-3013 citations