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Linezolid (LZD)

DRUG9 trials

Sponsors

National Institute of Allergy and Infectious Diseases (NIAID), Ain Shams University, Beijing Chest Hospital, London School of Hygiene and Tropical Medicine, Wuhan Pulmonary Hospital

Conditions

BoneDouble J StentImpaired Renal FunctionInfant and Young ChildrenJointLinezolidLinezolid Pharmacokinetics in Young InfantsMeningitis

Phase 1

Phase II Clinical Study of Contezolid for the Treatment of Bone and Joint Tuberculosis
Enrolling by invitationNCT06811012
Beijing Chest HospitalBone, Joint, Tuberculosis
Start: 2024-01-31End: 2025-12-31Target: 24Updated: 2025-02-06
Phase II Clinical Study of Contezolid for the Treatment of Tuberculous Meningitis
Enrolling by invitationNCT06811025
Beijing Chest HospitalMeningitis, Tuberculosis
Start: 2024-02-01End: 2025-12-31Target: 24Updated: 2025-02-06
Bacteriophage Therapy for Mycobacterium Abscessus Pulmonary Infection
Enrolling by invitationNCT07228702
Vancouver Coastal HealthMycobacterium Abscessus Infection, Non-Tuberculous Mycobacterial (NTM) Pneumonia
Start: 2026-01-11End: 2027-10-01Target: 1Updated: 2026-06-03

Phase 2

Trial of a Six-Month Regimen of High-Dose Rifampicin, High-Dose Isoniazid, Linezolid, and Pyrazinamide Versus a Standard Nine-Month Regimen for the Treatment of Adults and Adolescents With Tuberculous Meningitis
RecruitingNCT05383742
National Institute of Allergy and Infectious Diseases (NIAID)Tuberculous Meningitis
Start: 2023-12-07End: 2029-09-15Target: 330Updated: 2026-06-02
Comprehensive Ambulatory Antibiotics for the Treatment of Congenital Syphilis
RecruitingNCT06921213
London School of Hygiene and Tropical MedicineSyphilis, Congenital
Start: 2026-05-04End: 2027-06-30Target: 90Updated: 2026-09-10

Phase 4

Microbiological Characteristics of Biofilm on Double J Ureteral Stents After Lithotripsy.
Not yet recruitingNCT07301294
Menoufia UniversityDouble J Stent
Start: 2026-01-01End: 2026-07-01Target: 100Updated: 2025-12-24
Oral Antibiotic Pharmacokinetics in Young Infants
Not yet recruitingNCT07815613
University of Colorado, DenverInfant and Young Children, Linezolid, Linezolid Pharmacokinetics in Young Infants +1
Start: 2027-01-01End: 2030-12-31Target: 40Updated: 2026-09-11

Unknown Phase

Compare Linezolid-Induced Thrombocytopenia in Patients With Normal Renal Function Versus Impaired Renal Function
CompletedNCT06761131
Ain Shams UniversityImpaired Renal Function, Thrombocytopaenia
Start: 2024-05-20End: 2025-06-20Updated: 2025-07-25
6 Months of Bedaquiline(BDQ), Delamanid(DLM), Linezolid(LZD) and Levofloxacin(LFX) in RR-TB Patients in Hubei Province
Not yet recruitingNCT07198685
Wuhan Pulmonary HospitalTreatment Duration, Treat to Target
Start: 2025-09-30End: 2028-09-30Target: 52Updated: 2025-09-30

Related Papers

Effectiveness and safety of shortened intensive treatment for children with tuberculous meningitis (SURE): a protocol for a phase 3 randomised controlled trial evaluating 6 months of antituberculosis therapy and 8 weeks of aspirin in Asian and African children with tuberculous meningitis
BMJ Open2025-04-016 citations