Levact 2
Sponsors
F. Hoffmann-La Roche AG, Fundacio Institut De Recerca De L'Hospital De La Santa Creu I Sant Pau, BeOne Medicines AG
Conditions
Chronic Lymphocytic Leukemia (CLL)Chronic lymphotic leukemia and Small Lymphocytic lymphomaRefractary or relapse Hodgkin T CD30+ lymphomaRefractary or relapse non-Hodgkin T CD30+ lymphoma.Relapsed/refractory large B-cell non-Hodgkin lymphomaand follicular lymphomamantle cell lymphoma
Phase 1
Inmmunotherapy with peripheral blood, autologous, a dult T cells, expanded and transduced (gene modified) with a lentiviral vector expressing an anti-CD30-chimeric antigen receptor with 4-1-BB and CD3z costimulatory sequences in patients with Classical Hodgkin lymphoma and non-Hodgkin CD30+ T cell lymphoma.
Not yet recruitingCTIS2024-515624-36-00
Target: 40Updated: 2025-08-29
IMMUNOTHERAPY WITH DIFFERENTIATED T CELLS, ADULTS, AUTOLOGOUS, FROM PERIPHERAL BLOOD, SELECTED BY CD62L EXPRESSION, EXPANDED AND TRANSDUCED (GENETICALLY MODIFIED) THROUGH A LENTIVIRAL VECTOR TO EXPRESS A CHIMERIC RECEPTOR WITH ANTI-CD19 SPECIFICITY ASSOCIATED WITH CO-STIMULATORY SEQUENCES 4-1-BB AND CD3Ζ IN PATIENTS WITH B-CELL NON-HODGKIN LYMPHOMA.
Not yet recruitingCTIS2024-519790-19-00
Target: 40Updated: 2025-09-29
Phase 3
A Prospective, Open-Label, Multicenter Randomized Phase III Study to Compare the Efficacy and Safety of a Combined Regimen of Venetoclax and Obinutuzumab Versus Fludarabine, Cyclophosphamide, and Rituximab (FCR)/ Bendamustine and Rituximab (BR) in FIT Patients with previously untreated Chronic Lymphocytic Leukemia (CLL) without DEL(17P) or TP53 Mutation
CompletedCTIS2023-504036-17-00
Start: 2020-05-07End: 2025-03-18Target: 121Updated: 2025-04-17
A Phase 3, Open-Label, Randomized Study of BGB-16673 Compared to Investigator’s Choice (Idelalisib Plus Rituximab or Bendamustine Plus Rituximab or Venetoclax Plus Rituximab Retreatment) in Patients With Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma Previously Exposed to Both BTK and BCL2 Inhibitors
RecruitingCTIS2024-518893-15-00
Start: 2025-07-29Target: 56Updated: 2026-01-14