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Letrozole (Aromatase Inhibitors)

DRUG5 trials

Sponsors

Zhejiang Cancer Hospital, Martin Blomberg Jensen, CMH Kharian Medical College, University of Novi Sad, Universitaire Ziekenhuizen KU Leuven

Conditions

Early Breast CancerFrozen Embryo Transfer (FET)Hormone-receptor-positive Breast CancerInfertility FemaleInfertility, MaleNeoadjuvant TherapyPolyendocrine Metabolic Ovarian Syndrome (PMOS)

Phase 1

NT-NOA - Novel Treatment of Some Men With Non-Obstructive Azoospermia
Active, not recruitingNCT06706414
Martin Blomberg JensenInfertility, Male
Start: 2025-03-01End: 2026-08-01Target: 16Updated: 2026-04-17

Phase 2

Clinical Study of Local and Systemic Biological Impact of GLP1/GIP-Receptor Agonists in Patients With Breast Cancer: The CLARA Trial
Not yet recruitingNCT07676331
Universitaire Ziekenhuizen KU LeuvenEarly Breast Cancer, Hormone-receptor-positive Breast Cancer
Start: 2026-08-01End: 2028-05-01Target: 168Updated: 2026-07-07

Phase 3

Aromatase Inhibitors Plus Chemotherapy vs Chemotherapy as Neoadjuvant Treatment in Postmenopausal HR(+) Breast Cancer
NCT02769104
Zhejiang Cancer HospitalNeoadjuvant Therapy
Start: 2016-05-31End: 2019-12-31Target: 120Updated: 2018-01-09

Unknown Phase

Endometrial Response in Polyendocrine Metabolic Ovarian Syndrome (PMOS) Treated With Letrozole Alone or With Added Estradiol Valerate
CompletedNCT07379502
CMH Kharian Medical CollegePolyendocrine Metabolic Ovarian Syndrome (PMOS)
Start: 2026-03-05End: 2026-08-31Updated: 2026-09-10
FET-LET-2x2: Clinical Pregnancy Rates After Frozen Embryo Transfer in Natural and Modified Natural Cycles
Not yet recruitingNCT07425990
University of Novi SadFrozen Embryo Transfer (FET), Infertility Female
Start: 2026-02-01End: 2027-03-01Target: 120Updated: 2026-02-23