Lesinurad

DRUG9 trials

Sponsors

Ardea Biosciences, Inc., Ironwood Pharmaceuticals, Inc.

Conditions

Chronic Kidney Disease (CKD)GoutTophaceous Gout

Phase 1

Single and Multiple Dose Study in Japanese

CompletedNCT01744379

Ardea Biosciences, Inc.Gout

Start: 2012-12-31End: 2013-05-31Updated: 2013-06-19

Phase 3

Combining Lesinurad With Allopurinol in Inadequate Responders

CompletedNCT01493531

Ardea Biosciences, Inc.Gout

Start: 2011-12-31End: 2014-07-31Updated: 2016-05-26

Lesinurad Monotherapy in Gout Subjects Intolerant to Xanthine Oxidase Inhibitors

CompletedNCT01508702

Ardea Biosciences, Inc.Gout

Start: 2012-01-31End: 2013-11-30Updated: 2016-02-12

Combining Lesinurad With Allopurinol in Inadequate Responders

CompletedNCT01510158

Ardea Biosciences, Inc.Gout

Start: 2012-01-31End: 2014-08-31Updated: 2016-08-18

Combination Treatment Study in Subjects With Tophaceous Gout With Lesinurad and Febuxostat

CompletedNCT01510769

Ardea Biosciences, Inc.Tophaceous Gout

Start: 2012-01-31End: 2014-06-30Updated: 2016-05-26

Open-Label Lesinurad Monotherapy Extension Study in Gout

CompletedNCT01650246

Ardea Biosciences, Inc.Gout

Start: 2012-08-31End: 2014-08-31Updated: 2016-05-26

Lesinurad and Allopurinol Combination Extension Study in Gout

CompletedNCT01808131

Ardea Biosciences, Inc.Gout

Start: 2013-02-28End: 2016-11-30Updated: 2017-01-24

Lesinurad and Febuxostat Combination Extension Study in Gout

CompletedNCT01808144

Ardea Biosciences, Inc.Gout

Start: 2013-03-01End: 2016-10-06Updated: 2018-01-30

Phase 4

A Phase 4 Safety and Efficacy Study to Evaluate Lesinurad 200 mg in Participants With Gout and Renal Impairment

TerminatedNCT03226899

Ironwood Pharmaceuticals, Inc.Chronic Kidney Disease (CKD), Gout

Start: 2017-07-19End: 2019-02-25Updated: 2021-11-04

Related Papers

Efficacy and safety during extended treatment of lesinurad in combination with febuxostat in patients with tophaceous gout: CRYSTAL extension study.

2019-01-0716 citations

Lesinurad monotherapy in gout patients intolerant to a xanthine oxidase inhibitor: a 6 month phase 3 clinical trial and extension study

Lara D. Veeken2017-08-24113 citations

Lesinurad in combination with allopurinol: a randomised, double-blind, placebo-controlled study in patients with gout with inadequate response to standard of care (the multinational CLEAR 2 study)

Annals of the Rheumatic Diseases2016-11-08161 citations

Lesinurad Provides Additional Lowering of SUA in Gout

MD Conference Express2014-12-01