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lerodalcibep

DRUG13 trials

Sponsors

Lib Therapeutics LLC, LIB Therapeutics Inc., LIB Therapeutics LLC, Hasten Biopharmaceutical Co., Ltd., Sponsor LIB Therapeutics Inc

Conditions

ASCVDAtherosclerotic Ischemic DiseaseCardiovascular DiseaseCardiovascular Disease With Mention of ArteriosclerosisCardiovascular DiseasesCardiovascular Risk FactorCardiovascular StrokeDyslipidemias

Phase 3

Phase 3 Study to Evaluate the Efficacy and Safety of LIB003 With Evolocumab in HoFH
CompletedNCT04034485
LIB Therapeutics LLCHomozygous Familial Hypercholesterolemia
Start: 2019-12-07End: 2023-01-30Updated: 2023-03-29
Trial to Evaluate Efficacy and Safety of LIB003, Evolocumab and Alirocumab in High-risk CVD Patients
CompletedNCT04790513
LIB Therapeutics LLCCardiovascular Diseases, Hypercholesterolemia
Start: 2021-04-22End: 2022-12-31Updated: 2023-03-29
Study of Efficacy and Safety of LIB003 in Patient With CVD on Statins Requiring Additional LDL-C Reduction
NCT04797247
LIB Therapeutics LLCCardiovascular Diseases, Hyper-LDL-cholesterolemia
Start: 2021-04-22End: 2024-02-28Target: 900Updated: 2023-12-11
Long-term Efficacy and Safety of OLE LIB003 in HoFH, HeFH, and High-risk CVD Patients Requiring Further LDL-C Reduction
Enrolling by invitationNCT04798430
LIB Therapeutics LLCCardiovascular Disease With Mention of Arteriosclerosis, Elevated Cholesterol, Familial Hypercholesterolemia
Start: 2020-12-03End: 2025-12-31Target: 2000Updated: 2024-10-22
Study to Assess the Efficacy and Safety of LIB003 in HeFH Patients on Oral Lipid Therapy Needing Further LDL-C Reduction
CompletedNCT04797104
LIB Therapeutics LLCHeterozygous Familial Hypercholesterolemia
Start: 2021-04-22End: 2023-12-05Updated: 2023-12-11
Study of Long-Term Efficacy and Safety of LIB003 in CVD or High Risk for CVD Patients Needing Further LDL-C Reduction
NCT04806893
LIB Therapeutics LLCCardiovascular Diseases, Cardiovascular Risk Factor, Cardiovascular Stroke +1
Start: 2021-04-22End: 2024-02-28Target: 900Updated: 2023-12-11
Trial to Evaluate Efficacy and Safety of LIB003 and Inclisiran in High-risk CVD Patients
CompletedNCT05004675
LIB Therapeutics LLCAtherosclerotic Ischemic Disease, Hypercholesterolemia
Start: 2022-06-20End: 2024-10-15Updated: 2024-10-23
Cross-Over Study to Compare the Pharmacokinetics and Pharmacodynamics of LIB003 Process 1 and Process 2 Drug Product
CompletedNCT05234775
LIB Therapeutics LLCHypercholesterolemia
Start: 2022-01-28End: 2022-07-11Updated: 2022-07-14
Open-Label Extension Phase 3 Study to Evaluate the Long-Term Efficacy and Safety of LIB003 in Patients With Homozygous and Heterozygous Familial Hypercholesterolemia, Cardiovascular Disease, or at High Risk for Cardiovascular Disease, on Stable Lipid-Lowering Therapy Requiring Additional Low-Density Lipoprotein Cholesterol Reduction (LIBerate-OLE)
CompletedCTIS2023-510057-41-00
Lib Therapeutics LLCCardiovascular Disease, or at High Risk for Cardiovascular Disease, Patients With Homozygous and Heterozygous Familial Hypercholesterolemia
Start: 2021-10-06End: 2025-08-19Target: 590Updated: 2025-04-02
A Study on Efficacy and Safety of HST101 in Chinese Patients with Hypercholesterolemia
RecruitingNCT06568471
Hasten Biopharmaceutical Co., Ltd.ASCVD, Dyslipidemias, Heterozygous Familial Hypercholesterolemia +4
Start: 2024-11-16End: 2026-05-31Target: 210Updated: 2025-02-06
Randomized, Placebo-Controlled, Double-Blind, Phase 3b Study to Evaluate the Efficacy and Safety of Lerodalcibep in Children and Adolescents, 6 to 17 Years of Age, with Heterozygous Familial Hypercholesterolemia on Stable Diet and Oral Lipid-Lowering Therapy (LIBerate-Kids)
Not yet recruitingCTIS2025-524214-28-00
LIB Therapeutics Inc.Heterozygous Familial Hypercholesterolemia
Target: 5Updated: 2026-05-13
Randomized, Placebo-Controlled, Double-Blind, Phase 3b Study to Evaluate the Efficacy and Safety of Lerodalcibep in Children 6 to 17 Years, With Heterozygous FH
Active, not recruitingPACTR202605715221380
Sponsor LIB Therapeutics IncHeterozygous Familial Hypercholesterolemia HeFH
Start: 2026-07-01Target: 50Updated: 2026-09-14
Long-Term Efficacy and Safety of Lerodalcibep in Children and Adolescents With Familial Hypercholesterolemia
Not yet recruitingNCT07775339
LIB Therapeutics LLCHeterozygous Familial Hypercholesterolemia (HeFH)
Start: 2027-01-20End: 2031-12-31Target: 150Updated: 2026-08-25

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