Leptin

DRUG12 trials

Sponsors

Rockefeller University, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), University of Michigan, Columbia University, Beth Israel Deaconess Medical Center

Conditions

Generalized LipodystrophyHIV InfectionsHIV LipodystrophyHealthyHypoleptinemiaInsulin ResistanceLeanLeptin Levels

Phase 1

Trial of Leptin Administration After Roux-en-Y Gastric Bypass

CompletedNCT00710814

Columbia UniversityOverweight

Start: 2008-04-30End: 2014-07-31Updated: 2015-11-16

Effects of Metreleptin in Type 1 Diabetes Mellitus

TerminatedNCT01268644

University of Texas Southwestern Medical CenterType 1 Diabetes

Start: 2010-09-30End: 2014-08-31Updated: 2019-08-28

In Vivo Leptin Signaling in Humans After Acute Leptin Administration

CompletedNCT01275053

Beth Israel Deaconess Medical CenterLean, Obese, Obese Diabetics

Start: 2002-07-31End: 2017-01-31Updated: 2017-10-17

Phase 2

Effects of Leptin Treatment on Weight Loss

CompletedNCT00050791

Rockefeller UniversityObesity

Start: 2001-03-31End: 2009-06-30Target: 40Updated: 2010-10-19

Combination of Insulin Sensitizer and Leptin as Treatment for the HAART -Induced Metabolic Syndrome

CompletedNCT00362440

Beth Israel Deaconess Medical CenterHIV Lipodystrophy

Start: 2006-08-31End: 2011-06-30Updated: 2017-03-23

Therapeutic Approaches to HAART-Induced Lipodystrophy

CompletedNCT00461552

University of Texas Southwestern Medical CenterHIV Infections, Lipodystrophy

Start: 2003-01-31End: 2014-09-30Updated: 2019-05-09

Trial of Leptin Replacement Therapy in Patients With Lipodystrophy

CompletedNCT00896298

University of Texas Southwestern Medical CenterGeneralized Lipodystrophy, Hypoleptinemia, Insulin Resistance +1

Start: 2006-04-30End: 2014-11-30Updated: 2024-03-27

Leptin in the Maintenance of Reduced Body Weight

CompletedNCT01155180

Beth Israel Deaconess Medical CenterObesity

Start: 2008-07-31End: 2016-12-31Updated: 2017-04-07

Phase 3

Low-Dose Leptin and the Formerly-Obese

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)Obesity

Start: 2000-07-31End: 2015-07-31Target: 25Updated: 2015-06-04

Phase 4

Leptin and Endothelial Function

CompletedNCT00121433

University of MichiganHealthy

Start: 2004-09-30End: 2004-12-31Target: 15Updated: 2006-06-27

Unknown Phase

Leptin in Human Energy and Neuroendocrine Homeostasis

TerminatedNCT00265980

Columbia UniversityObesity, Weight Loss

Start: 2002-07-31End: 2013-07-31Updated: 2019-09-18

Salivary and Serum Leptin Levels in Oral Lichen Planus Patients: A Case-control Study.

CompletedNCT06078579

Cairo UniversityLeptin Levels, Oral Lichen Planus

Start: 2023-12-30End: 2024-12-30Updated: 2025-03-30