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LENVIMA 4 mg hard capsules

DRUG16 trials

Sponsors

AstraZeneca AB, Eisai Limited, Het Nederlands Kanker Instituut-Antoni van Leeuwenhoek Ziekenhuis Stichting, Salubris Biotherapeutics Inc., Merck Healthcare KGaA

Conditions

Advanced Hepatobiliary CancerAdvanced Renal Cell CarcinomaAdvanced hepatocellular carcinoma (HCC)Advanced solid tumorCentral Nervous System TumorsHepatocellular carcinomaLocoregional Hepatocellular Carcinoma (HCC)Multiple myeloma

Phase 1

A Multicenter, Open-Label Phase 1/2 Trial Evaluating the Safety, Tolerability, and Efficacy of MORAb-202, a folate receptor alpha (FRα)-targeting antibody-drug conjugate (ADC) in Subjects With Selected Tumor Types
Active, not recruitingCTIS2023-506868-14-00
Eisai Limitedand non-small cell lung cancer adenocarcinoma; NSCLC)., endometrial cancer (EC), Solid tumors in 4 tumor types: platinum resistant ovarian cancer +1
Start: 2023-02-28Target: 90Updated: 2025-12-29
An Open-Label Study of E7386 in Combination With Other Anticancer Drug(s) in Subjects With Solid Tumors
Active, not recruitingCTIS2023-510275-64-00
Eisai Limitedcolorectal cancer, endometrial cancer, Hepatocellular carcinoma +1
Start: 2023-05-31Target: 83Updated: 2025-11-07
An open-label, multicenter, phase 1b/2 study of E7386 in combination with pembrolizumab in previously treated subjects with selected solid tumors
CompletedCTIS2023-505425-14-00
Eisai Limitedcolorectal cancer, hepatocellular carcinoma, melanoma
Start: 2022-08-11End: 2024-10-15Target: 30Updated: 2024-09-30
A Phase 1/2, Multicenter, Open Label, Dose Escalation & Dose Expansion Study of JK08, an IL-15 Antibody Fusion Protein Targeting CTLA-4, Monotherapy or in Combination in Patients with Unresectable Locally Advanced or Metastatic Cancer
CompletedCTIS2024-511750-53-00
Salubris Biotherapeutics Inc.Unresectable Locally Advanced or Metastatic Cancer
Start: 2022-09-08End: 2025-04-25Target: 130Updated: 2025-02-14
A Phase 1b, Open-label Study to Evaluate the Safety, Tolerability, Pharmacokinetics, Immunogenicity, and Antitumor Activity of MEDI5752 in Combination with Axitinib in Subjects with Advanced Renal Cell Carcinoma
Active, not recruitingCTIS2023-509604-15-00
AstraZeneca ABAdvanced Renal Cell Carcinoma
Start: 2021-02-15Target: 93Updated: 2025-11-20
Single-arm, multicenter Phase I/Ib study of avelumab + lenvatinib in children with primary CNS tumors
SuspendedCTIS2024-512940-51-00
Merck Healthcare KGaACentral Nervous System Tumors
Start: 2021-11-24Target: 23Updated: 2025-10-16
Study of the benefit of lenvatinib treatment in waiting list of liver transplantation after TACE failure in patients with hepatocellular carcinoma (HCC) : Ta-Len-Tra
Not yet recruitingCTIS2024-516408-40-00
Assistance Publique Hopitaux De ParisNon-resectable hepatocellular carcinoma (HCC)
Target: 25Updated: 2024-10-14

Phase 2

A Phase II, Open-Label, Multi-Drug, Multi-Center, Master Protocol to Evaluate the Efficacy and Safety of Novel Immunomodulators as Monotherapy and in Combination with Anticancer Agents in Participants with Advanced Hepatobiliary Cancer (GEMINI-Hepatobiliary)
RecruitingCTIS2022-502317-29-00
AstraZeneca ABAdvanced Hepatobiliary Cancer
Start: 2023-07-12Target: 60Updated: 2025-12-11
A Dutch National Study on behalf of the Center for Personalized Cancer Treatment (CPCT) to Facilitate Patient Access to Commercially Available, Targeted Anti-cancer Drugs to determine the Potential Efficacy in Treatment of Advanced Cancers with a Known Molecular Profile: The Drug Rediscovery Protocol (DRUP trial)
RecruitingCTIS2023-509152-33-00
Het Nederlands Kanker Instituut-Antoni van Leeuwenhoek Ziekenhuis StichtingAdvanced solid tumor, Multiple myeloma, Non-Hodgkin lymphoma +1
Start: 2016-07-25Target: 3000Updated: 2025-12-19
LENVAGIST - A multicentre, comparative, placebo-controlled, double-blinded, phase II study of the efficacy of lenvatinib in patients with locally advanced or metastatic GIST after failure of imatinib and sunitinib
CompletedCTIS2024-513984-22-00
Centre Leon BerardPatients with metastatic GIST
Start: 2020-03-17End: 2025-03-12Target: 74Updated: 2025-11-19
PEMbrolizumab Plus Lenvatinib In Second Line And Third Line Malignant Pleural MEsotheLiomA Patients: A Single Arm Phase II Study (PEMMELA).
Active, not recruitingCTIS2024-516618-39-00
Het Nederlands Kanker Instituut-Antoni van Leeuwenhoek Ziekenhuis Stichtingmalignant pleural mesothelioma
Start: 2021-02-25Target: 58Updated: 2024-09-24
SOLARIS – A phase-II open-label study of pembrolizumab and lenvatinib in patients with advanced stage hepatocellular carcinoma who are refractory to atezolizumab and bevacizumab/ IO-based therapy
CompletedCTIS2024-515731-29-00
Frankfurter Institut Fuer Klinische Krebsforschung IKF GmbHadvanced stage hepatocellular carcinoma
Start: 2022-03-30End: 2025-06-30Target: 32Updated: 2025-08-01
LENVABLA Lenvatinib in neo-adjuvant and adjuvant therapy for poor-prognosis BCLC A HepatoCellular Carcinoma treated by percutaneous ablation procedure in a curative intent: multicentre pilot therapeutic trial
Not yet recruitingCTIS2024-514606-31-00
Assistance Publique Hopitaux De ParisPatients with Biopsy-proven or radiologically-suggested BCLC A HCC eligible for PA and comprising at least one of the following criteria: - Single tumour>3 cm≤ 5cm or - multiple tumours (max 3 lesions ≤ 3cm) or - Single tumour between 2 and 3 cm with at least one of the following characteristic: • Serum AFP>100 ng/mL • Infiltrative form • Macro-trabecular subtype (if applicable)
Target: 50Updated: 2024-10-29
rEECur: International Randomised Controlled Trial of Chemotherapy for the Treatment of Recurrent and Primary Refractory Ewing Sarcoma
RecruitingCTIS2024-516078-31-00
The University Of BirminghamRecurrent and Primary Refractory Ewing Sarcoma
Start: 2015-05-05Target: 436Updated: 2024-12-04

Phase 3

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