LENVIMA 4 mg hard capsules
Sponsors
AstraZeneca AB, Eisai Limited, Het Nederlands Kanker Instituut-Antoni van Leeuwenhoek Ziekenhuis Stichting, Salubris Biotherapeutics Inc., Merck Healthcare KGaA
Conditions
Advanced Hepatobiliary CancerAdvanced Renal Cell CarcinomaAdvanced hepatocellular carcinoma (HCC)Advanced solid tumorCentral Nervous System TumorsHepatocellular carcinomaLocoregional Hepatocellular Carcinoma (HCC)Multiple myeloma
Phase 1
A Multicenter, Open-Label Phase 1/2 Trial Evaluating the Safety, Tolerability, and Efficacy of MORAb-202, a folate receptor alpha (FRα)-targeting antibody-drug conjugate (ADC) in Subjects With Selected Tumor Types
Active, not recruitingCTIS2023-506868-14-00
Start: 2023-02-28Target: 90Updated: 2025-12-29
An Open-Label Study of E7386 in Combination With Other Anticancer Drug(s) in Subjects With Solid Tumors
Active, not recruitingCTIS2023-510275-64-00
Start: 2023-05-31Target: 83Updated: 2025-11-07
An open-label, multicenter, phase 1b/2 study of E7386 in combination with pembrolizumab in previously treated subjects with selected solid tumors
CompletedCTIS2023-505425-14-00
Start: 2022-08-11End: 2024-10-15Target: 30Updated: 2024-09-30
A Phase 1/2, Multicenter, Open Label, Dose Escalation & Dose Expansion Study of JK08, an IL-15 Antibody Fusion Protein Targeting CTLA-4, Monotherapy or in Combination in Patients with Unresectable Locally Advanced or Metastatic Cancer
CompletedCTIS2024-511750-53-00
Start: 2022-09-08End: 2025-04-25Target: 130Updated: 2025-02-14
A Phase 1b, Open-label Study to Evaluate the Safety, Tolerability, Pharmacokinetics, Immunogenicity, and Antitumor Activity of MEDI5752 in Combination with Axitinib in Subjects with Advanced Renal Cell Carcinoma
Active, not recruitingCTIS2023-509604-15-00
Start: 2021-02-15Target: 93Updated: 2025-11-20
Single-arm, multicenter Phase I/Ib study of avelumab + lenvatinib in children with primary CNS tumors
SuspendedCTIS2024-512940-51-00
Start: 2021-11-24Target: 23Updated: 2025-10-16
Study of the benefit of lenvatinib treatment in waiting list of liver transplantation after TACE failure in patients with hepatocellular carcinoma (HCC) : Ta-Len-Tra
Not yet recruitingCTIS2024-516408-40-00
Target: 25Updated: 2024-10-14
Phase 2
A Phase II, Open-Label, Multi-Drug, Multi-Center, Master Protocol to Evaluate the Efficacy and Safety of Novel Immunomodulators as Monotherapy and in Combination with Anticancer Agents in Participants with Advanced Hepatobiliary Cancer (GEMINI-Hepatobiliary)
RecruitingCTIS2022-502317-29-00
Start: 2023-07-12Target: 60Updated: 2025-12-11
A Dutch National Study on behalf of the Center for Personalized Cancer Treatment (CPCT) to Facilitate Patient Access to Commercially Available, Targeted Anti-cancer Drugs to determine the Potential Efficacy in Treatment of Advanced Cancers with a Known Molecular Profile: The Drug Rediscovery Protocol (DRUP trial)
RecruitingCTIS2023-509152-33-00
Start: 2016-07-25Target: 3000Updated: 2025-12-19
LENVAGIST - A multicentre, comparative, placebo-controlled, double-blinded, phase II study of the efficacy of lenvatinib in patients with locally advanced or metastatic GIST after failure of imatinib and sunitinib
CompletedCTIS2024-513984-22-00
Start: 2020-03-17End: 2025-03-12Target: 74Updated: 2025-11-19
PEMbrolizumab Plus Lenvatinib In Second Line And Third Line Malignant Pleural MEsotheLiomA Patients: A Single Arm Phase II Study (PEMMELA).
Active, not recruitingCTIS2024-516618-39-00
Start: 2021-02-25Target: 58Updated: 2024-09-24
SOLARIS – A phase-II open-label study of pembrolizumab and lenvatinib in patients with advanced stage hepatocellular carcinoma who are refractory to atezolizumab and bevacizumab/ IO-based therapy
CompletedCTIS2024-515731-29-00
Start: 2022-03-30End: 2025-06-30Target: 32Updated: 2025-08-01
LENVABLA Lenvatinib in neo-adjuvant and adjuvant therapy for poor-prognosis BCLC A HepatoCellular Carcinoma treated by percutaneous ablation procedure in a curative intent: multicentre pilot therapeutic trial
Not yet recruitingCTIS2024-514606-31-00
Target: 50Updated: 2024-10-29
rEECur: International Randomised Controlled Trial of Chemotherapy for the Treatment of Recurrent and Primary Refractory Ewing Sarcoma
RecruitingCTIS2024-516078-31-00
Start: 2015-05-05Target: 436Updated: 2024-12-04
Phase 3
A Phase III, Randomized, Open-Label, Sponsor-Blinded, Multicenter Study of Durvalumab in Combination with Tremelimumab ± Lenvatinib Given Concurrently with Transarterial Chemoembolization (TACE) Compared to TACE Alone in Patients with Locoregional Hepatocellular Carcinoma (EMERALD-3)
Active, not recruitingCTIS2023-508701-24-00
Start: 2022-11-21Target: 131Updated: 2026-01-20
A prospective, randomized, placebo-controlled, double-blind, multicenter phase III registration clinical study to compare toripalimab (JS001) combined with lenvatinib versus placebo combined with lenvatinib as the 1st-line therapy for advanced hepatocellular carcinoma (HCC)
Active, not recruitingCTIS2024-514207-34-00
Start: 2021-07-08Target: 22Updated: 2025-12-12