lemborexant,placebo

3 trials

Sponsors

Ratchadapiseksompotch Fund, Faculty of Medicine, Chulalongkorn University, Ratchadaphiseksomphot Endowment Fund, Faculty of Medicine, Chulalongkorn University

Conditions

Adults with moderate-to-severe obstructive sleep apnea and low respiratory arousal threshold who are initiating CPAP therapy for the first time Obstructive Sleep Apnea Continuous Positive Airway Pressure Treatment Adherence and Compliance Orexin Receptor AntagonistModerate to severe OSA patients with low arousal threshold Apnea/Hypopnea Index (AHI) Lemborexant Obstructive Sleep Apnea (OSA) Low Arousal Threshold Polysomnographychronic insomnia in COPD patients Insomnia, COPD, Lemborexant

Phase 1

A Randomized, Double-blind, Placebo-Controlled Trial on the Effects of Lemborexant as a Treatment for moderate-to-severe OSA Patients with Low Arousal Threshold

Active, not recruitingTCTR20210217004

Ratchadapiseksompotch Fund, Faculty of Medicine, Chulalongkorn UniversityModerate to severe OSA patients with low arousal threshold Apnea/Hypopnea Index (AHI) Lemborexant Obstructive Sleep Apnea (OSA) Low Arousal Threshold Polysomnography

Start: 2024-10-01Target: 10Updated: 2026-08-03

Phase 2

Effect of Lemborexant on CPAP Compliance in OSA Patients with Low Respiratory Arousal Threshold

Active, not recruitingTCTR20260626003

Faculty of Medicine, Chulalongkorn UniversityAdults with moderate-to-severe obstructive sleep apnea and low respiratory arousal threshold who are initiating CPAP therapy for the first time Obstructive Sleep Apnea Continuous Positive Airway Pressure Treatment Adherence and Compliance Orexin Receptor Antagonist

Start: 2026-09-01Target: 38Updated: 2026-08-03

Phase 4

The effects of lemborexant on chronic insomnia management in COPD patients

Active, not recruitingTCTR20251231001

Ratchadaphiseksomphot Endowment Fundchronic insomnia in COPD patients Insomnia, COPD, Lemborexant

Start: 2025-11-01Target: 24Updated: 2026-08-03