Lefamulin

DRUG5 trials

Sponsors

Nabriva Therapeutics AG, University of Washington

Conditions

Community Acquired PneumoniaCystic FibrosisHealthyMycoplasma Genitalium Infection

Phase 1

Bioavailability and Pharmacokinetics of Lefamulin When Administered to Fed and Fasted Healthy Subjects

CompletedNCT02557789

Nabriva Therapeutics AGHealthy

Start: 2015-06-30End: 2015-06-30Updated: 2015-09-23

Lefamulin for M. Genitalium Treatment Failures

TerminatedNCT05111002

University of WashingtonMycoplasma Genitalium Infection

Start: 2022-04-22End: 2023-11-30Updated: 2024-10-26

Study to Assess the Safety and PK of Oral and IV Xenleta in Adults With Cystic Fibrosis

CompletedNCT05225805

Nabriva Therapeutics AGCystic Fibrosis

Start: 2022-03-01End: 2023-01-13Updated: 2024-06-17

Phase 3

Study to Compare Lefamulin to Moxifloxacin (With or Without Linezolid) for the Treatment of Adults With Pneumonia

CompletedNCT02559310

Nabriva Therapeutics AGCommunity Acquired Pneumonia

Start: 2015-09-30End: 2017-05-31Updated: 2019-10-23

Study to Compare Lefamulin to Moxifloxacin for the Treatment of Adults With Pneumonia

CompletedNCT02813694

Nabriva Therapeutics AGCommunity Acquired Pneumonia

Start: 2016-08-31End: 2018-01-31Updated: 2019-10-23

Related Papers

Safety and Pharmacokinetics Following Oral or Intravenous Lefamulin in Adults With Cystic Fibrosis.

2024-01-081 citations

Lefamulin efficacy and safety in a pooled phase 3 clinical trial population with community-acquired bacterial pneumonia and common clinical comorbidities

BMC Pulmonary Medicine2021-05-0825 citations

Efficacy and Safety of Intravenous-to-oral Lefamulin, a Pleuromutilin Antibiotic, for the Treatment of Community-acquired Bacterial Pneumonia: The Phase III Lefamulin Evaluation Against Pneumonia (LEAP 1) Trial.

2019-11-0195 citations

Oral Lefamulin vs Moxifloxacin for Early Clinical Response Among Adults With Community-Acquired Bacterial Pneumonia

JAMA2019-09-27103 citations

LB6. Oral Lefamulin Is Safe and Effective in the Treatment of Adults With Community-Acquired Bacterial Pneumonia (CABP): Results of Lefamulin Evaluation Against Pneumonia (LEAP 2) Study

Open Forum Infectious Diseases2018-11-0110 citations