Lamivudine (3TC)

DRUG13 trials

Conditions

AIDSAicardi-Goutières SyndromeHIV InfectionHIV InfectionsHIV-1-infectionHealthyInfection, Human Immunodeficiency Virus

Phase 1

Pharmacokinetics of Lamivudine at Two Different Doses

CompletedNCT00985647

Kirby InstituteHIV Infections

Start: 2009-12-31End: 2010-03-31Updated: 2011-02-11

A Clinical Study of Islatravir and Its Interaction With Lamivudine (MK-8591-058)

CompletedNCT06811246

Merck Sharp & Dohme LLCHealthy

Start: 2024-02-07End: 2024-07-14Updated: 2025-02-06

Phase 2

Once-daily Highly Active Antiretroviral Treatment Regimen Administration in HIV-1 Infected Children in Burkina Faso (ANRS 12103 BURKINAME)

CompletedNCT00122538

French National Agency for Research on AIDS and Viral HepatitisAIDS, HIV Infections

Start: 2006-02-28End: 2009-05-31Updated: 2011-12-05

Tipranavir Dose-response Study Using a Prototype Self-emulsifying Drug Delivery System (SEDDS) Formulation in Treatment-naive HIV-1 Infected Patients Report on the Post-study Option, a Treatment of Triple Therapy With Delavirdine, ZDV and 3TC Without Tipranavir

CompletedNCT02249130

Boehringer IngelheimHIV Infections

Start: 1999-03-31Updated: 2014-09-25

Antiretroviral Treatment Guided by Proviral Genotype: Pilot Trial of Proof of Concept.

NCT03539224

Instituto de Investigación Hospital Universitario La PazHIV-1-infection

Start: 2017-11-02End: 2021-07-31Updated: 2020-07-07

Inhibition of Reverse Transcription in Aicardi-Goutières Syndrome

CompletedNCT04731103

University of EdinburghAicardi-Goutières Syndrome

Start: 2022-08-24End: 2024-03-11Updated: 2024-05-09

Phase 3

Randomised Trial of Structured Treatment Interruption of HAART in HIV-Infected Adults in Abidjan (ANRS 1269 TRIVACAN)

CompletedNCT00158405

French National Agency for Research on AIDS and Viral HepatitisHIV Infections

Start: 2002-12-31End: 2006-12-31Updated: 2008-12-30

Comparison of Efficacy and Safety of Infant Peri-exposure Prophylaxis With Lopinavir/Ritonavir Versus Lamivudine to Prevent HIV-1 Transmission by Breastfeeding

CompletedNCT00640263

French National Agency for Research on AIDS and Viral HepatitisHIV Infections

Start: 2009-12-31End: 2014-02-28Target: 1500Updated: 2014-04-14

Efficacy of Nevirapine Compared to ZDV + 3TC Administered in Labor and Again at Postdelivery in HIV Positive Women

CompletedNCT02181933

Boehringer IngelheimHIV Infections

Start: 1999-04-30Updated: 2014-07-14

An Efficacy, Safety, and Tolerability Study Comparing Dolutegravir Plus Lamivudine With Dolutegravir Plus Tenofovir/Emtricitabine in Treatment naïve HIV Infected Subjects (Gemini 1)

CompletedNCT02831673

ViiV HealthcareHIV Infections, Infection, Human Immunodeficiency Virus

Start: 2016-07-21End: 2022-08-15Updated: 2023-08-24

An Efficacy, Safety, and Tolerability Study Comparing Dolutegravir (DTG) Plus Lamivudine (3TC) With Dolutegravir Plus Tenofovir/Emtricitabine in Treatment naïve HIV Infected Participants (Gemini 2)

CompletedNCT02831764

ViiV HealthcareHIV Infections, Infection, Human Immunodeficiency Virus

Start: 2016-07-18End: 2022-06-29Updated: 2023-12-07

An Adaptive Platform Trial for Evaluation of Novel Treatment Regimens in Children and Adolescents With HIV in Africa

Not yet recruitingNCT07792096

University College, LondonHIV Infection

Start: 2026-11-01End: 2029-12-01Target: 800Updated: 2026-08-28

Unknown Phase

'COMBINE-2': Real-world Evidence for Effectiveness of Two Drug Regimen, Antiretroviral Therapy With Integrase Inhibitors Plus a Reverse Transcriptase Inhibitor

CompletedNCT04019873

ViiV HealthcareHIV Infections

Start: 2019-11-18End: 2023-12-05Updated: 2025-01-22

Open Forum Infectious Diseases2025-02-282 citations

Reverse transcriptase inhibitors in Aicardi–Goutières syndrome: A crossover clinical trial

Developmental Medicine & Child Neurology2024-12-044 citations

Long-term Evaluation of Residual Viremia in a Clinical Trial of Dolutegravir Plus Lamivudine as Maintenance Treatment for Participants With and Without Prior Lamivudine Resistance

Open Forum Infectious Diseases2022-11-0111 citations

Impact of treatment adherence on efficacy of dolutegravir plus lamivudine and dolutegravir plus tenofovir disoproxil fumarate/emtricitabine: pooled analysis of the GEMINI-1 and GEMINI-2 clinical studies

HIV Research & Clinical Practice2021-12-1611 citations

The prevalence and socio-behavioural and clinical covariates of oral health related quality of life in Ugandan mothers with and without HIV-1

Health and Quality of Life Outcomes2021-08-2310 citations

1024. Impact of Treatment Adherence on Efficacy of DTG/3TC and DTG + TDF/FTC: Pooled Analysis of the GEMINI 1 and 2 Clinical Trials

Open Forum Infectious Diseases2020-10-011 citations

Antiretroviral treatment and its impact on oral health outcomes in 5 to 7 year old Ugandan children

Medicine2020-09-247 citations

Dolutegravir plus lamivudine for maintenance of HIV viral suppression in adults with and without historical resistance to lamivudine: 48-week results of a non-randomized, pilot clinical trial (ART-PRO).

2020-05-1126 citations

Caries experience and oral health related quality of life in a cohort of Ugandan HIV-1 exposed uninfected children compared with a matched cohort of HIV unexposed uninfected children.

2020-03-3016 citations

Clinical and Biological Factors Associated With Early Epstein-Barr Virus Infection in Human Immunodeficiency Virus–Exposed Uninfected Infants in Eastern Uganda

Clinical Infectious Diseases2020-02-1311 citations

Association of maternal HIV‐1 severity with dental caries: an observational study of uninfected 5‐ to 7‐yr‐old children of HIV‐1‐infected mothers without severe immune suppression

European Journal Of Oral Sciences2020-01-295 citations

2842. Durable Efficacy of Two-Drug Regimen (2DR) of Dolutegravir (DTG) plus Lamivudine (3TC) in Antiretroviral Treatment-Naïve Adults with HIV-1 Infection at 96 Weeks: Subgroup Analyses in the GEMINI Studies

Open Forum Infectious Diseases2019-10-01

Lopinavir-Ritonavir Impairs Adrenal Function in Infants

Clinical Infectious Diseases2019-09-0510 citations

Growth in HIV-1-exposed but uninfected infants treated with lopinavir-ritonavir versus lamivudine: a secondary analysis of the ANRS 12174 trial.

2019-02-2411 citations

Dolutegravir plus lamivudine versus dolutegravir plus tenofovir disoproxil fumarate and emtricitabine in antiretroviral-naive adults with HIV-1 infection (GEMINI-1 and GEMINI-2): week 48 results from two multicentre, double-blind, randomised, non-inferiority, phase 3 trials.

2018-11-09272 citations

Dolutegravir–lamivudine as initial therapy in HIV‐1 infected, ARV‐naive patients, 48‐week results of the PADDLE (Pilot Antiretroviral Design with Dolutegravir LamivudinE) study

Journal of the International AIDS Society2017-01-01101 citations

Breastfeeding patterns and its determinants among mothers living with Human Immuno-deficiency Virus -1 in four African countries participating in the ANRS 12174 trial

International Breastfeeding Journal2016-12-0112 citations

Are Prophylactic and Therapeutic Target Concentrations Different?: the Case of Lopinavir-Ritonavir or Lamivudine Administered to Infants for Prevention of Mother-to-Child HIV-1 Transmission during Breastfeeding

Antimicrobial Agents and Chemotherapy2016-11-297 citations

Extended pre-exposure prophylaxis with lopinavir-ritonavir versus lamivudine to prevent HIV-1 transmission through breastfeeding up to 50 weeks in infants in Africa (ANRS 12174): a randomised controlled trial.

2015-11-1962 citations

A novel pharmacokinetic approach to predict virologic failure in HIV-1-infected paediatric patients.

2013-03-018 citations

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