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Ladarixin

DRUG10 trials

Sponsors

Dompe' Farmaceutici S.p.A., Ospedale San Raffaele S.r.l., Dompé Farmaceutici S.p.A, NYU Langone Health

Conditions

Advanced Non-small Cell Lung Cancer With KRAS G12C MutationDiabetes Mellitus, Insulin-DependentNew-onset Type 1 DiabetesRecent Onset type1 DiabetesRecent onset Type 1 DiabetesType 1 DiabetesType I Diabetesnew-onset autoimmune type 1 diabetes

Phase 1

Phase 2

A Phase 2, Multicentre, Randomized, Double-blind, Placebo-controlled Study in Patients With New-onset Type 1 Diabetes
CompletedNCT02814838
Dompé Farmaceutici S.p.ADiabetes Mellitus, Insulin-Dependent
Start: 2016-08-31End: 2019-05-15Updated: 2024-04-19
A Study of Oral Ladarixin in Recent Onset Type 1 Diabetes and a Low Residual β-cell Function
TerminatedNCT04628481
Dompé Farmaceutici S.p.ARecent Onset type1 Diabetes
Start: 2021-01-12End: 2025-10-21Updated: 2025-12-17
A Study to Assess Efficacy/Safety of Ladarixin in Type 1 Diabetes Patients With Preserved ß-cell Function at Baseline.
TerminatedNCT04899271
Dompé Farmaceutici S.p.ANew-onset Type 1 Diabetes
Start: 2020-12-14End: 2023-10-11Updated: 2025-05-14
Ladarixin as Adjunctive Therapy to Improve Insulin Sensitivity and Glucometabolic Outcomes in Type 1 Diabetes
WithdrawnNCT05035368
Dompé Farmaceutici S.p.AType I Diabetes
Start: 2021-09-30End: 2023-06-30Updated: 2023-12-22
Clinical Trial on Ladarixin Adjunctive Therapy to Improve Glycemic Control in Type 1 Diabetes.
TerminatedNCT05368402
Dompé Farmaceutici S.p.AType 1 Diabetes
Start: 2022-09-14End: 2023-09-18Updated: 2025-02-03
Ladarixin With Sotorasib in Advanced NSCLC - Phase II
WithdrawnNCT05815186
NYU Langone HealthAdvanced Non-small Cell Lung Cancer With KRAS G12C Mutation
Start: 2024-04-30End: 2026-04-30Updated: 2024-03-29
A phase 2, multicenter, randomized, double-blind, placebo-controlled study to assess the effect and safety of 400 mg twice a day oral ladarixin in patients with recent onset type 1 diabetes and a low residual β-cell function at baseline.
CompletedCTIS2024-513560-26-00
Dompe' Farmaceutici S.p.A.Recent onset Type 1 Diabetes
Start: 2020-12-10End: 2025-10-21Target: 103Updated: 2024-12-20
A phase 2b, single-center, randomized, double-blind, placebo-controlled study to assess the efficacy and safety of oral Ladarixin in association with a single low dose of Antithymocyte Globulin in patients with new-onset autoimmune type 1 diabetes.
WithdrawnCTIS2025-524298-18-00
Ospedale San Raffaele S.r.l.new-onset autoimmune type 1 diabetes
Target: 46Updated: 2026-04-09

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