LABA

DRUG6 trials

Sponsors

Merck Sharp & Dohme LLC, Hoffmann-La Roche, Novartis Pharmaceuticals, GlaxoSmithKline, Erasme University Hospital

Conditions

AsthmaCOPDPulmonary Disease, Chronic Obstructive

Phase 1

A Study to Evaluate the Safety and Use of Human Rhinovirus in Healthy and Asthmatic Participants (MK-0000-218)

CompletedNCT01866306

Merck Sharp & Dohme LLCAsthma

Start: 2013-10-22End: 2016-01-18Updated: 2018-09-04

Phase 2

A Study to Measure Serum Periostin, Asthma-Related Biomarkers and Response to Prednisolone in Adult and Adolescent Patients With Severe Oral Corticosteroid-Dependent Asthma

CompletedNCT01948401

Hoffmann-La RocheAsthma

Start: 2013-07-31End: 2014-04-30Updated: 2016-11-02

Phase 3

Effects of Acute Long-acting Bronchodilation on Oxygenation and Peripheral Ventilation in COPD

CompletedNCT05927155

Erasme University HospitalPulmonary Disease, Chronic Obstructive

Start: 2021-06-15End: 2022-03-30Updated: 2023-07-03

Phase 4

Study to Evaluate the Efficacy and Safety of Glycopyrronium or Indacaterol Maleate and Glycopyrronium Bromide Fixed-dose Combination Regarding Symptoms and Health Status in Patients With Moderate COPD Switching From Treatment With Any Standard COPD Regimen

CompletedNCT01985334

Novartis PharmaceuticalsCOPD

Start: 2014-02-14End: 2016-04-29Updated: 2019-03-19

Longitudinal Cohort Study in Participants With Severe Asthma to Assess Biomarkers

CompletedNCT02537691

Hoffmann-La RocheAsthma

Start: 2015-08-28End: 2017-07-10Updated: 2019-04-09

INTREPID: Investigation of TRELEGY Effectiveness: Usual Practice Design

CompletedNCT03467425

GlaxoSmithKlinePulmonary Disease, Chronic Obstructive

Start: 2018-04-11End: 2019-10-10Updated: 2020-09-07

Related Papers

Pragmatic randomised controlled trials in COPD and asthma: how to guide clinical practice

BMJ Open Respiratory Research2022-09-013 citations

Cost-effectiveness of single- vs multiple-inhaler triple therapy in a UK COPD population: INTREPID trial

2021-09-051 citations

INTREPID study: Once-daily single-inhaler fluticasone furoate/umeclidinium/vilanterol vs multiple-inhaler triple therapy; sub-analysis by prior medication strata

2020-09-07

Clinical effectiveness of once-daily fluticasone furoate/umeclidinium/vilanterol in usual practice: the COPD INTREPID study design

ERJ Open Research2019-10-0115 citations

Change in type-2 biomarkers and related cytokines with prednisolone in uncontrolled severe oral corticosteroid dependent asthmatics: an interventional open-label study

Thorax2019-04-0227 citations

Indacaterol/glycopyrronium reduces the risk of clinically important deterioration after direct switch from baseline therapies in patients with moderate COPD: a post hoc analysis of the CRYSTAL study.

2018-04-1613 citations

Efficacy and safety of direct switch to indacaterol/glycopyrronium in patients with moderate COPD: the CRYSTAL open-label randomised trial

Respiratory Research2017-07-1854 citations

Assessing biomarkers in a real-world severe asthma study (ARIETTA).

2016-04-1415 citations