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L-theanine

DIETARY_SUPPLEMENT6 trials

Sponsors

University of British Columbia, Sha'ar Menashe Mental Health Center, Texas Tech University, Icahn School of Medicine at Mount Sinai, Butler Hospital

Conditions

Attention Deficit Hyperactivity DisorderCaffeine and L-theanine InteractionCognitive PerformanceCortical ExcitabilityPhysical Performance EnhancementPsychiatric DisorderSchizophrenia

Early Phase 1

Effects of L-theanine and Caffeine on Attention and Attention-related Brain Activity of Children With Attention Deficit Hyperactivity Disorder
CompletedNCT03533556
Texas Tech UniversityAttention Deficit Hyperactivity Disorder
Start: 2018-05-14End: 2018-08-31Updated: 2019-04-12
Effects of L-theanine on Motor Cortex Excitability in Healthy Subjects: A Paired-Pulse TMS Study
CompletedNCT04749745
Butler HospitalCortical Excitability, Psychiatric Disorder
Start: 2020-06-09End: 2021-05-31Updated: 2021-09-23

Phase 2

Effects of L-Theanine in Boys With ADHD
CompletedNCT00291070
University of British ColumbiaAttention Deficit Hyperactivity Disorder
Start: 2005-10-31End: 2006-07-31Target: 100Updated: 2008-05-06

Phase 3

L-Theanine in the Management of Schizophrenia
CompletedNCT00372151
Sha'ar Menashe Mental Health CenterSchizophrenia
Start: 2006-10-31End: 2008-12-31Updated: 2008-12-16

Phase 4

Assessing the Effectiveness of an N-of-1 Platform Using Study of Cognitive Enhancers
TerminatedNCT04056650
Icahn School of Medicine at Mount SinaiCognitive Performance
Start: 2019-10-18End: 2020-12-22Updated: 2021-03-12

Unknown Phase

Effects of Caffeine and L-Theanine on Physical and Cognitive Performance in Trained Athletes
CompletedNCT07268573
Ulaş Can YILDIRIMCaffeine and L-theanine Interaction, Cognitive Performance, Physical Performance Enhancement
Start: 2025-08-01End: 2025-08-14Updated: 2025-12-08

Related Papers

Acute effects of combined and isolated caffeine and theanine supplementation on physical and cognitive performance in competitive athletes: a randomized, double-blind, placebo-controlled crossover study
Frontiers in Nutrition2026-01-26
Measuring the Effects of Caffeine and L-Theanine on Cognitive Performance: A Protocol for Self-Directed, Mobile N-of-1 Studies
Frontiers in Computer Science2020-02-1310 citations
Factors Associated With Trial Completion and Adherence in App-Based N-of-1 Trials: Protocol for a Randomized Trial Evaluating Study Duration, Notification Level, and Meaningful Engagement in the Brain Boost Study
JMIR Research Protocols2019-12-033 citations