L-serine

DRUG9 trials

Conditions

Alzheimer DiseaseAmyotrophic Lateral Sclerosis (ALS)EpilepsyGRIN Related DisordersGRIN-related DisordersGRIN1GRIN2AGRIN2B

Phase 1

L-Serine Supplementation in Hereditary Sensory Neuropathy Type 1

CompletedNCT01733407

Massachusetts General HospitalHereditary Sensory and Autonomic Neuropathy Type I

Start: 2013-09-30End: 2017-07-31Updated: 2018-09-12

Determining the Safety of L-serine in ALS

NCT01835782

Phoenix Neurological Associates, LTDAmyotrophic Lateral Sclerosis (ALS)

Start: 2013-01-31Target: 20Updated: 2015-07-30

Phase 2

Phase IIa L-serine Trial for eAD

TerminatedNCT03062449

Aleksandra StarkAlzheimer Disease

Start: 2017-03-01End: 2021-07-20Updated: 2024-07-03

Tolerability and Efficacy of L-Serine in Patients With Amyotrophic Lateral Sclerosis (ALS)

TerminatedNCT03580616

Elijah W. StommelAmyotrophic Lateral Sclerosis (ALS)

Start: 2018-10-24End: 2022-12-20Updated: 2025-04-20

Hereditary Sensory Neuropathy Serine Trial

NCT06113055

University College, LondonHereditary Sensory Neuropathy Type I

Start: 2023-08-21End: 2025-08-31Target: 50Updated: 2023-11-02

Phase 3

Study of Serine Supplementation to Protect Vision in MacTel

Not yet recruitingNCT07342439

The Lowy Medical Research Institute LimitedMacular Telangiectasia Type 2 (MacTel)

Start: 2026-09-30End: 2030-02-28Target: 120Updated: 2026-01-15

TAP-GRIN: Interventional Study on Patients With GRIN-related Neurodevelopmental Disorders

RecruitingNCT07377032

Meyer Children's Hospital IRCCSEpilepsy, GRIN1, GRIN2A +4

Start: 2025-08-29End: 2028-06-01Target: 40Updated: 2026-01-29

Unknown Phase

Short Term Dietary Serine Supplementation and Circulating Serine Levels

WithdrawnNCT02528994

Massachusetts General HospitalSerine

Start: 2016-09-30End: 2016-09-30Updated: 2016-09-16

Tolerability and Efficacy of L-Serine in Patients With GRIN-related Encephalopathy

NCT04646447

Fundació Sant Joan de DéuGRIN Related Disorders

Start: 2020-07-30End: 2022-05-31Target: 20Updated: 2020-11-30

Related Papers

L-serine treatment in patients with <i>GRIN</i>-related encephalopathy: a phase 2A, non-randomized study

Brain2024-02-2125 citations

A possible blood plasma biomarker for early-stage Alzheimer’s disease

PLoS ONE2022-04-218 citations

Randomized trial of <scp>l</scp> -serine in patients with hereditary sensory and autonomic neuropathy type 1

Neurology2019-01-10111 citations