L-methylfolate

DRUG6 trials

Sponsors

Pamlab, Inc., Massachusetts General Hospital, University of Florida, Riphah International University, Queen's University

Conditions

Attention Deficit Hyperactivity DisorderDepressionGeneralized Anxiety DisorderMajor Depressive DisorderSchizophrenia

Phase 2

L-methylfolate Supplementation to OROS-Methylphenidate Pharmacotherapy in ADHD Adults

CompletedNCT01853280

Massachusetts General HospitalAttention Deficit Hyperactivity Disorder

Start: 2014-05-31End: 2017-09-30Updated: 2017-11-14

Phase 4

Adjunctive Treatment With L-methylfolate for Treatment-Resistant Generalized Anxiety Disorder: a Pilot Study

RecruitingNCT06218030

Queen's UniversityGeneralized Anxiety Disorder

Start: 2024-10-22End: 2026-05-01Target: 10Updated: 2025-05-25

Unknown Phase

Combination Deplin® and Antidepressant Therapy for a Major Depressive Episode (MDE)- a Retrospective Analysis

CompletedNCT01001559

Pamlab, Inc.Major Depressive Disorder

Start: 2009-08-31End: 2011-06-30Updated: 2013-12-19

A Placebo-Controlled Study of Physiologic Effects of L-methylfolate in Schizophrenia Patients

CompletedNCT01091506

Pamlab, Inc.Schizophrenia

Start: 2010-03-31End: 2014-06-30Updated: 2016-08-03

The Use Of L-Methylfolate As A Treatment For Depression

CompletedNCT02133898

University of FloridaDepression

Start: 2016-02-29End: 2023-04-04Updated: 2023-06-07

Combination Therapy of Different Antidepressants With Dietary Supplements

CompletedNCT05931965

Riphah International UniversityDepression

Start: 2022-10-05End: 2023-08-31Updated: 2023-09-11

Related Papers

Clinical evaluation of adjunctive magnesium therapy in patients receiving antidepressants for depression-open label, nonrandomized clinical trial.

2026-06-12

Effect of combination therapy of methylfolate with antidepressants in patients with depressive disorder

BMC Pharmacology and Toxicology2025-01-221 citations

Biochemical, physiological and clinical effects of l-methylfolate in schizophrenia: a randomized controlled trial

Molecular Psychiatry2017-03-1466 citations