L-Histidine

DIETARY_SUPPLEMENT7 trials

Sponsors

Tourmaline Bio Inc., London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's, University of Miami, McMaster University, Wake Forest University Health Sciences

Conditions

Alzheimer DiseaseHARS SyndromeHealthy AdultIrritable Bowel SyndromeMultiple SclerosisThyroid Eye Disease

Early Phase 1

Biomarkers of Diet-microbiota Interactions in Irritable Bowel Syndrome

CompletedNCT04364750

McMaster UniversityIrritable Bowel Syndrome

Start: 2021-07-15End: 2026-02-10Updated: 2026-04-13

Phase 1

Histaminergic Basis of Central Fatigue in Multiple Sclerosis - A Novel Approach

CompletedNCT03266965

University of MiamiMultiple Sclerosis

Start: 2018-03-23End: 2020-08-07Updated: 2020-10-08

Phase 2

Histidine Therapy: A Project to Treat HARS Deficiency

London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph'sHARS Syndrome

Start: 2018-08-01End: 2022-12-31Updated: 2022-06-10

Histaminergic Basis of Fatigue in Multiple Sclerosis

WithdrawnNCT04764383

University of MiamiMultiple Sclerosis

Start: 2022-01-01End: 2022-10-30Updated: 2021-07-29

A Multicenter Phase 2b Randomized, Double-Masked, Placebo-Controlled Dose-Ranging Study of TOUR006 in Participants with Thyroid Eye Disease.

RecruitingCTIS2024-514801-69-00

Tourmaline Bio Inc.Thyroid Eye Disease

Start: 2025-04-02Target: 48Updated: 2026-01-22

Phase 4

Histidine Oral Supplementation as a Therapeutic Modality for Alzheimer's Disease

WithdrawnNCT06169826

Wake Forest University Health SciencesAlzheimer Disease

Start: 2025-04-30End: 2026-04-30Updated: 2025-04-27

Unknown Phase

Effect of Monosodium Glutamate on Microbiome-Derived Imidazole Propionate Production in Healthy Volunteers

Not yet recruitingNCT07700368

University of ChicagoHealthy Adult

Start: 2026-07-15End: 2027-12-31Target: 18Updated: 2026-07-14