L-glutamine

DRUG12 trials

Sponsors

Emmaus Medical, Inc., Assistance Publique - Hôpitaux de Paris, Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, UCSF Benioff Children's Hospital Oakland, Eastern Regional Medical Center

Conditions

Advanced Pancreatic AdenocarcinomaDiabetes Mellitus, Type 2Diverticulosis, ColonicEczemaMTOROC1 SignalingMuscular Dystrophy, DuchenneNon-transfusion Dependent ThalassemiaPancreatic Cancer

Early Phase 1

Glutamine Supplementation in People With Immune Dysregulation

WithdrawnNCT04019769

National Institute of Allergy and Infectious Diseases (NIAID)Eczema, MTOROC1 Signaling

Start: 2020-03-12End: 2021-01-01Updated: 2020-03-16

Phase 1

L-glutamine Supplementation to Alleviate Symptoms of Taxane-Induced Neuropathy in Patients With Breast Cancer

WithdrawnNCT02215083

Eastern Regional Medical CenterPeripheral Neuropathy

Start: 2014-08-31End: 2015-04-30Updated: 2017-07-12

The Effect of Pharmaceutical Grade L-glutamine (Endari) on Glycemic Control in Patients With Diabetes Mellitus Type II

Hawaii Pacific HealthDiabetes Mellitus, Type 2

Start: 2019-05-31End: 2022-05-31Target: 25Updated: 2019-05-13

Trial of First-line L-glutamine With Gemcitabine and Nab-paclitaxel in Advanced Pancreatic Cancer

CompletedNCT04634539

Jun Gong, MDAdvanced Pancreatic Adenocarcinoma, Pancreatic Cancer, Pancreatic Ductal Adenocarcinoma

Start: 2021-05-13End: 2025-06-17Updated: 2025-08-06

L-glutamine Treatment in Patients With Diverticulosis

CompletedNCT05106101

Emmaus Medical, Inc.Diverticulosis, Colonic

Start: 2019-07-19End: 2022-12-30Updated: 2023-02-16

Phase 2

L-Glutamine Therapy for Sickle Cell Anemia and Sickle ß0 Thalassemia

CompletedNCT00125788

Emmaus Medical, Inc.Sickle Cell Anemia, Thalassemia

Start: 2004-03-31End: 2008-07-31Updated: 2021-01-29

Effect of Oral Glutamine on Muscle Mass and Function in Duchenne Muscular Dystrophy

CompletedNCT00296621

Assistance Publique - Hôpitaux de ParisMuscular Dystrophy, Duchenne

Start: 2006-02-28End: 2007-11-30Updated: 2007-12-21

L-Glutamine Therapy for Sickle Cell Anemia

TerminatedNCT00586209

Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical CenterSickle Cell Anemia, Thalassemia

Start: 2004-02-06End: 2009-11-30Updated: 2021-02-02

Glutamine Therapy for Hemolysis-Associated Pulmonary Hypertension

CompletedNCT01048905

UCSF Benioff Children's Hospital OaklandPulmonary Hypertension, Sickle Cell Disease, Thalassemia

Start: 2009-03-31End: 2014-03-31Updated: 2021-06-10

Effect of L-Glutamine on Pulmonary Artery Pressure in Patients With Non-Transfusion-Dependent Thalassemia

CompletedNCT07210450

Mazandaran University of Medical SciencesNon-transfusion Dependent Thalassemia, Pulmonary Artery Pressure, Thalassemia

Start: 2023-08-15End: 2025-09-27Updated: 2025-10-07

Phase 3

A Phase III Safety and Efficacy Study of L-Glutamine to Treat Sickle Cell Disease or Sickle βo-thalassemia

CompletedNCT01179217

Emmaus Medical, Inc.Sickle Cell Anemia, Sickle ß0-Thalassemia

Start: 2010-05-31End: 2014-03-31Updated: 2020-08-19

Phase 4

Pharmacokinetics and Safety of Endari (L-glutamine) in Sickle Cell Disease Patients

CompletedNCT04684381

Emmaus Medical, Inc.Pharmacokinetics, Sickle Cell Disease

Start: 2021-01-04End: 2021-06-30Updated: 2022-08-02

Related Papers

l-Glutamine in combination with first-line gemcitabine and nab-paclitaxel in advanced pancreatic ductal adenocarcinoma: an open-label, single-arm, phase 1 GlutaPanc trial

Nature Cancer2026-08-31

The effect of cachexia and anti-cancer therapies on GDF-15 levels in patients with pancreatic adenocarcinoma.

Journal of Clinical Oncology2025-01-271 citations

A Population Pharmacokinetic Analysis of l-Glutamine Exposure in Patients with Sickle Cell Disease: Evaluation of Dose and Food Effects

Clinical Pharmacokinetics2024-02-246 citations

Effects of L-Glutamine on Biomarkers of Response in Sickle Cell Disease: A Pharmacokinetics-Pharmacodynamics Analysis

Blood2023-11-023 citations

Evaluation of Dosage and Food Effect on L-Glutamine Exposure for Sickle Cell Anemia: A Population Pharmacokinetic Analysis

Blood2022-11-15

A phase I study of first-line L-glutamine (Gln) with gemcitabine (gem) and nab-paclitaxel (nab-p) in advanced pancreatic cancer (GlutaPanc).

Journal of Clinical Oncology2022-01-19

Pharmacokinetics of L-Glutamine (Endari) in Pediatric and Adult Sickle Cell Disease Patients: A Phase 4, Open-Label, Single-Center Study

Blood2021-11-052 citations

A Phase 3 Trial of l-Glutamine in Sickle Cell Disease.

2018-07-01384 citations

Lack of functional benefit with glutamine versus placebo in Duchenne muscular dystrophy: a randomized crossover trial.

2009-05-0618 citations