Kymriah 1.2 x 10^6 – 6 x 10^8 cells dispersion for infusion

DRUG4 trials

Sponsors

Lymphoma Academic Research Organisation, Assistance Publique Hopitaux De Paris, Centre Hospitalier Universitaire De Saint Etienne, Universitair Ziekenhuis Gent

Conditions

Patients undergoing Fludarabine based lymphodepletion prior to CAR-T cell therapyadolescents and young adults with Acute Lymphoblastic Leukemiachildrenfor hematological malignancyhematologyrelapsed or refractory patients with aggressive large B-cell lymphoma at high risk of relapse

Phase 1

CAPTIRALL _ Combination of an Anti-PD1 antibody with Tisagenlecleucel Reinfusion in children, adolescents and young adults with Acute Lymphoblastic Leukemia after loss of persistence

Active, not recruitingCTIS2024-514345-11-00

Assistance Publique Hopitaux De Parisadolescents and young adults with Acute Lymphoblastic Leukemia, children

Start: 2023-03-15Target: 26Updated: 2024-08-19

Phase 2

CARMOD - Golcadomide (BMS-986369) post-CAR T-cell in R/R Aggressive large B-cell lymphoma patients with high risk of relapse

RecruitingCTIS2023-506705-20-00

Lymphoma Academic Research Organisationrelapsed or refractory patients with aggressive large B-cell lymphoma at high risk of relapse

Start: 2024-06-14Target: 61Updated: 2024-05-28

Phase 4

Temporal characterization of Extracellular Vesicles during cellular therapy using CAR-T cells and during the occurrence of Immune effector Cell-Associated Neurotoxicity Syndrome : the VESICANS study

RecruitingCTIS2024-515328-35-00

Centre Hospitalier Universitaire De Saint Etiennehematology

Start: 2025-07-02Target: 60Updated: 2025-04-17

Fludarabine exposure in patients undergoing Fludarabine based lymphodepletion prior to CAR-T cell therapy

Not yet recruitingCTIS2025-524278-40-00

Universitair Ziekenhuis Gentfor hematological malignancy, Patients undergoing Fludarabine based lymphodepletion prior to CAR-T cell therapy

Target: 75Updated: 2026-03-23