Kuvan

DRUG11 trials

Conditions

AgingBioavailabilityCardiovascular DiseaseHeart FailureHyperphenylalaninaemiaMenopausePhenylketonuriaPhenylketonuria (PKU)

Early Phase 1

Sex Hormones and Atherosclerosis Prevention in Perimenopausal Women

CompletedNCT02042196

University of Colorado, DenverAging, Menopause

Start: 2013-12-31End: 2016-05-02Target: 100Updated: 2019-07-11

Phase 1

Kuvan in People With Schizophrenia and Schizoaffective Disorder

CompletedNCT01706965

New York State Psychiatric InstituteSchizoaffective Disorder, Schizophrenia

Start: 2012-10-31End: 2016-06-30Updated: 2017-09-13

Study on Sapropterin Dihydrochloride Oral Suspension in Healthy Subjects

CompletedNCT06481709

APR Applied Pharma Research s.a.Bioavailability

Start: 2024-07-30End: 2024-08-31Updated: 2025-06-12

Phase 2

Kuvan Therapy in Phenylketonuria (PKU): The Effect of Blood Phenylalanine Concentration on Kuvan Response

CompletedNCT00841100

University of MiamiPhenylketonuria

Start: 2008-12-31End: 2011-07-19Updated: 2019-12-03

Phenylketonuria, Oxidative Stress, and BH4

TerminatedNCT01395394

Emory UniversityPhenylketonuria

Start: 2011-06-30End: 2013-06-30Updated: 2014-08-28

Phase 4

Effects of Kuvan on Melatonin Secretion

CompletedNCT01617070

University of Southern CaliforniaPhenylketonuria (PKU)

Start: 2012-05-31End: 2014-12-31Updated: 2016-11-18

Unknown Phase

PKUDOS: Phenylketonuria (PKU) Demographic, Outcomes, and Safety Registry

CompletedNCT00778206

BioMarin PharmaceuticalHyperphenylalaninaemia, Phenylketonuria

Start: 2008-09-30End: 2021-01-29Updated: 2022-10-12

Behavioral Effects of Kuvan in Children With Mild Phenylketonuria

TerminatedNCT00827762

Washington University School of MedicinePhenylketonuria

Start: 2009-01-31End: 2010-01-31Updated: 2013-12-05

A Pilot Study on Diurnal Variation

TerminatedNCT01806051

Dr. Linda RandolphPhenylketonuria (PKU)

Start: 2013-03-31End: 2014-05-31Updated: 2016-04-20

Rhode Island Diastolic Dysfunction - Heart Failure

CompletedNCT02353312

Providence VA Medical CenterCardiovascular Disease, Heart Failure

Start: 2015-03-31End: 2018-12-31Updated: 2025-07-03

Retrospective Observational Safety Effectiveness With Kuvan in hpA

CompletedNCT03864029

BioMarin PharmaceuticalTetrahydrobiopterin Deficiency

Start: 2017-10-10End: 2018-07-25Updated: 2019-03-07

Related Papers

Efficacy and safety of sapropterin before and during pregnancy: Final analysis of the Kuvan® Adult Maternal Paediatric European Registry (<scp>KAMPER</scp>) maternal and Phenylketonuria Developmental Outcomes and Safety (<scp>PKUDOS</scp>) <scp>PKU‐MOMs</scp> sub‐registries

Journal of Inherited Metabolic Disease2024-03-039 citations

Long-term comparative effectiveness of pegvaliase versus medical nutrition therapy with and without sapropterin in adults with phenylketonuria

Molecular Genetics and Metabolism2023-12-157 citations