KTN3379

BIOLOGICAL3 trials

Sponsors

Celldex Therapeutics

Conditions

Advanced CancerSquamous Cell Carcinoma of the Head and NeckThyroid Cancer

Phase 1

A Phase 1 Study to Evaluate the Safety and Pharmacokinetics of KTN3379 in Adult Subjects With Advanced Tumors

CompletedNCT02014909

Celldex TherapeuticsAdvanced Cancer

Start: 2014-01-31End: 2017-06-05Updated: 2017-07-24

Enhancing Radioiodine Incorporation Into BRAF Mutant Thyroid Cancers With the Combination of Vemurafenib and KTN3379

CompletedNCT02456701

Celldex TherapeuticsThyroid Cancer

Start: 2015-06-30End: 2016-10-13Updated: 2017-09-05

A Window of Opportunity Study of KTN3379 in Surgically Resectable Head and Neck Cancer Patients

CompletedNCT02473731

Celldex TherapeuticsSquamous Cell Carcinoma of the Head and Neck

Start: 2015-10-31End: 2016-10-10Updated: 2019-08-01

Related Papers

Abstract 4338: Response to neoadjuvant targeted therapy in operable head and neck cancer confers survival benefit

Cancer Research2023-04-04

Response to Neoadjuvant Targeted Therapy in Operable Head and Neck Cancer Confers Survival Benefit

Clinical Cancer Research2023-01-039 citations

Enhancing Radioiodine Incorporation in <i>BRAF</i> -Mutant, Radioiodine-Refractory Thyroid Cancers with Vemurafenib and the Anti-ErbB3 Monoclonal Antibody CDX-3379: Results of a Pilot Clinical Trial

Thyroid2022-01-2051 citations

Molecular and Clinical Activity of CDX-3379, an Anti-ErbB3 Monoclonal Antibody, in Head and Neck Squamous Cell Carcinoma Patients

Clinical Cancer Research2019-07-1535 citations

Safety, pharmacokinetics (PK), pharmacodynamics (Pd), and antitumor activity in a phase 1b study evaluating anti-ErbB3 antibody KTN3379 in adults with advanced tumors alone and with targeted therapies.

Journal of Clinical Oncology2016-05-2015 citations

A phase 1, open-label study to evaluate the safety and pharmacokinetics of the anti ErbB3 antibody, KTN3379, alone or in combination with targeted therapies in patients with advanced tumors.

Journal of Clinical Oncology2015-05-2011 citations