KQB198

DRUG4 trials

Sponsors

Kumquat Biosciences Inc.

Conditions

AdultCRC (Colorectal Cancer)GISTGIST - Gastrointestinal Stromal TumorGIST Metastatic CancerGastro Intestinal Stromal TumourGastrointestinal TumorsHematologic Malignancies

Phase 1

A Study to Investigate the Safety and Efficacy of KQB198 as Monotherapy and in Combination in Participants With Advanced Solid Malignancies

Active, not recruitingNCT06507306

Kumquat Biosciences Inc.Solid Tumor, Adult

Start: 2024-06-03End: 2027-01-31Updated: 2026-09-02

A Study to Investigate the Safety and Efficacy of KQB198 as Monotherapy and in Combination in Participants With Advanced Hematologic Malignancies

Active, not recruitingNCT06645886

Kumquat Biosciences Inc.Adult, Hematologic Malignancies

Start: 2024-12-09End: 2027-03-01Updated: 2026-03-25

A Study to Investigate the Safety and Efficacy of KQB365 as Monotherapy and in Combination in Participants With Advanced Solid Malignancies

RecruitingNCT06720987

Kumquat Biosciences Inc.CRC (Colorectal Cancer), KRAS G12C Mutation, KRAS G12S Mutation +1

Start: 2025-02-04End: 2030-06-30Target: 140Updated: 2026-04-23

Phase 2

KQB198 in Combination With Imatinib in Participants With Advanced/Metastatic GIST in 1st Line Setting (SynerGIST-1st Line)

RecruitingNCT07406633

Kumquat Biosciences Inc.Gastro Intestinal Stromal Tumour, Gastrointestinal Tumors, GIST +2

Start: 2026-06-23End: 2028-10-01Target: 46Updated: 2026-08-10