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DRUG18 trials

Sponsors

Bristol-Myers Squibb International Corporation, Immunogen Inc., Bristol Myers Squibb International Corporation, Pharmacosmos A/S, Bristol-Myers Squibb Services Unlimited Company

Conditions

Advanced dedifferentiated liposarcomaAdvanced or Metastatic CancerAdvanced throat and larynx cancerAdvanced/Metastatic Gastric cancerBladder Cancer Muscle-Invasive Bladder CancerEarly Stage Non-Small Cell Lung Cancer (NSCLC)Extensive Stage Small Cell Lung CancerGastric cancer

Phase 1

Phase 2

A phase II study of preoperative stereotactic radiation therapy boost combined with short-course immunotherapy (pembrolizumab versus placebo, randomized, double-blind) and standard chemotherapy in patients with newly diagnosed HER2-negative non-metastatic breast cancer with lack of early metabolic response in 18-fluorodeoxyglucoseFDG-PET/CT after 1st chemoterapy cycle
RecruitingCTIS2023-504145-31-00
Narodowy Instytut Onkologii Im. Marii Sklodowskiej-Curie-Panstwowy Instytut BadawczyHER2 negative breast cancer
Start: 2024-06-10Target: 78Updated: 2024-02-21
A Phase 1b/2a Three-Part Open-Label Multicenter Study to Evaluate the Safety and Efficacy of LY2880070 as Monotherapy and in Combination with Gemcitabine in Patients with Advanced or Metastatic Cancer with a Focus on Ovarian Cancer
CompletedCTIS2023-503459-91-00
Esperas Pharma Inc., Esperas Pharma Inc.Advanced or Metastatic Cancer
Start: 2023-11-21End: 2025-04-07Target: 12Updated: 2025-03-17
Brightline-1: A Phase II/III, randomized, open-label, multi-center study of brigimadlin (BI 907828) compared to doxorubicin as first line treatment of patients with advanced dedifferentiated liposarcoma
CompletedCTIS2024-511361-11-00
Boehringer Ingelheim International GmbH, Boehringer Ingelheim Espana S.A.Advanced dedifferentiated liposarcoma
Start: 2022-03-25End: 2025-11-21Target: 209Updated: 2025-07-04
The asssessment of the efficacy of induction radiochemotherapy using low doses of ionizing radiation (iCHRTL) in the treatment of patients with advanced throat and larynx cancer
RecruitingCTIS2024-517480-23-00
Narodowy Instytut Onkologii Im. Marii Sklodowskiej-Curie Panstwowy Instytut BadawczyAdvanced throat and larynx cancer
Start: 2022-02-17Target: 40Updated: 2025-01-31

Phase 3

A Phase 3, Randomized, Open Label Study to Compare Nivolumab plus Concurrent Chemoradiotherapy (CCRT) followed by Nivolumab plus Ipilimumab or Nivolumab plus CCRT Followed by Nivolumab vs CCRT followed by Durvalumab in Previously Untreated, Locally Advanced Nonsmall Cell Lung Cancer (LA NSCLC)
CompletedCTIS2022-502886-71-00
Bristol Myers Squibb International CorporationPreviously Untreated Locally Advanced Non-small Cell Lung Cancer (LA NSCLC)
Start: 2019-11-20End: 2024-05-31Target: 485Updated: 2024-05-20
Randomized, Open-Label, Phase 3 Trial of Nivolumab plus Ipilimumab or Nivolumab plus Platinum-Doublet Chemotherapy versus Platinum-Doublet Chemotherapy in Early Stage NSCLC
CompletedCTIS2022-501360-18-00
Bristol-Myers Squibb International CorporationEarly Stage Non-Small Cell Lung Cancer (NSCLC)
Start: 2017-03-15End: 2024-12-03Target: 194Updated: 2024-12-03
Randomized, Open-Label, Phase 3 Trial of Nivolumab plus Ipilimumab or Nivolumab plus Platinum-Doublet Chemotherapy versus Platinum-Doublet Chemotherapy in Early Stage NSCLC
CompletedCTIS2022-501360-18-00
Bristol-Myers Squibb International CorporationEarly Stage Non-Small Cell Lung Cancer (NSCLC)
Start: 2017-03-15End: 2024-12-03Target: 194Updated: 2024-12-03
A Randomized, Double-Blind, Placebo-Controlled Study of Trilaciclib vs Placebo in Patients with Extensive Stage Small Cell Lung Cancer (ES-SCLC) Receiving Topotecan Chemotherapy
RecruitingCTIS2022-502357-34-00
Pharmacosmos A/SExtensive Stage Small Cell Lung Cancer
Start: 2023-09-27Target: 250Updated: 2025-12-18
A Phase 3, Randomized, Double-blind Study of Neoadjuvant Chemotherapy plus Nivolumab versus Neoadjuvant Chemotherapy plus Placebo, followed by Surgical Resection and Adjuvant Treatment with Nivolumab or Placebo for Participants with Resectable Stage II-IIIB Non-small Cell Lung Cancer (CheckMate 77T, CHECKpoint pathway and nivoluMAb clinical Trial Evaluation 77T)
Active, not recruitingCTIS2022-502658-15-00
Bristol-Myers Squibb Services Unlimited CompanyResectable Stage II-IIIB Non-small cell lung cancer
Start: 2019-09-22Target: 252Updated: 2025-10-08
2022-501606-35-00 – Randomized, multicenter, open-label, Phase 3 study of mirvetuximab soravtansine in combination with bevacizumab versus bevacizumab alone as maintenance therapy for patients with FRα-high recurrent platinum-sensitive epithelial ovarian, fallopian tube, or primary peritoneal cancers who have not progressed after second-line platinum-based chemotherapy plus bevacizumab (GLORIOSA).
RecruitingCTIS2022-501606-35-01
Immunogen Inc.fallopian tube, or primary peritoneal cancers, Platinum-sensitive epithelial ovarian
Start: 2024-02-21Target: 110Updated: 2026-01-21
A Phase 3, Randomized Study of Nivolumab plus Ipilimumab in Combination with Chemotherapy vs Chemotherapy alone as First Line Therapy in Stage IV Non-Small Cell Lung Cancer (NSCLC)
CompletedCTIS2023-508757-75-00
Bristol Myers Squibb International CorporationStage IV Non-Small Cell Lung Cancer (NSCLC)
Start: 2017-09-18End: 2024-10-18Target: 456Updated: 2024-10-28
A Phase 3, Open-label, Randomized Study of Nivolumab Combined with Ipilimumab, or with Standard of Care Chemotherapy, versus Standard of Care Chemotherapy in Participants with Previously Untreated Unresectable or Metastatic Urothelial Cancer
Active, not recruitingCTIS2022-501784-40-00
Bristol Myers Squibb International CorporationUntreated Unresectable or Metastatic Urothelial Cancer
Start: 2017-05-26Target: 701Updated: 2026-01-26
A Phase 3, Randomized, Study of Neoadjuvant Chemotherapy alone versus Neoadjuvant Chemotherapy plus Nivolumab or Nivolumab and BMS- 986205, Followed by Continued Post- Surgery Therapy with Nivolumab or Nivolumab and BMS-986205 in Participants with Muscle-Invasive Bladder Cancer
Active, not recruitingCTIS2024-512158-12-00
Bristol-Myers Squibb Services Unlimited CompanyBladder Cancer Muscle-Invasive Bladder Cancer
Start: 2018-12-14Target: 386Updated: 2025-10-20
A Phase III Multi-center, Open-label, Sponsor-blinded, Randomized Study of AZD0901 Monotherapy Compared With Investigator’s Choice of Therapy in Second- or Later-Line Adult Participants with Advanced/Metastatic Gastric or Gastroesophageal Junction Adenocarcinoma Expressing Claudin 18.2 (CLARITY-Gastric 01)
RecruitingCTIS2023-508276-11-00
AstraZeneca ABAdvanced/Metastatic Gastric cancer, Gastric cancer, Gastroesophageal Junction Adenocarcinoma Expressing Claudin18.2
Start: 2025-01-17Target: 91Updated: 2025-09-15
A Randomized, Double-Blind, Placebo-Controlled Multicenter Study of Levosimendan Therapy in low ejection fraction Takotsubo Syndrome (LevoTako Trial)
CompletedCTIS2024-515060-32-00
Medical University Of GdanskTakotsubo syndrome
Start: 2024-11-22End: 2025-12-22Target: 190Updated: 2025-12-14
A PHASE III, RANDOMIZED, OPEN-LABEL STUDY EVALUATING THE EFFICACY AND SAFETY OF DIVARASIB AND PEMBROLIZUMAB VERSUS PEMBROLIZUMAB AND PEMETREXED AND CARBOPLATIN OR CISPLATIN IN PATIENTS WITH PREVIOUSLY UNTREATED, KRAS G12C-MUTATED, ADVANCED OR METASTATIC NON-SQUAMOUS NON-SMALL CELL LUNG CANCER
RecruitingCTIS2024-518365-10-00
F. Hoffmann-La Roche AGPreviously Untreated Advanced or Metastatic Non-Squamous Non−Small Cell Lung Cancer
Start: 2025-10-28Target: 282Updated: 2026-01-13