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kisspeptin 112-121

DRUG12 trials

Sponsors

Massachusetts General Hospital, Stephanie B. Seminara, MD

Conditions

AgonadismDelayed PubertyGnRH DeficiencyHealthy Postmenopausal WomenHyperprolactinemiaHypogonadismHypogonadotropic HypogonadismHypothalamic Amenorrhea

Phase 1

Kisspeptin Administration in the Adult
CompletedNCT00914823
Massachusetts General HospitalGnRH Deficiency, Hyperprolactinemia, Hypogonadotropic Hypogonadism +3
Start: 2009-06-23End: 2021-10-22Updated: 2024-07-31
Elucidating Kisspeptin Physiology by Blocking Kisspeptin Signaling
CompletedNCT01438073
Massachusetts General HospitalAgonadism, Healthy Postmenopausal Women, Hypogonadotropic Hypogonadism
Start: 2011-09-30End: 2016-04-30Updated: 2022-07-11
Kisspeptin in the Evaluation of Delayed Puberty
CompletedNCT01438034
Massachusetts General HospitalDelayed Puberty, GnRH Deficiency, Hypogonadotropic Hypogonadism +1
Start: 2013-06-08End: 2021-09-10Updated: 2023-10-19
Neuropeptides in Human Reproduction
CompletedNCT01952782
Massachusetts General HospitalHypogonadotropic Hypogonadism
Start: 2014-04-30End: 2016-05-31Updated: 2024-07-31
Kisspeptin Administration Subcutaneously to Patients With Reproductive Disorders
CompletedNCT05633966
Stephanie B. Seminara, MDHypogonadotropic Hypogonadism, Hypothalamic Amenorrhea
Start: 2022-12-16End: 2025-08-31Updated: 2025-10-03
Recall by Genotype: Neuropeptide Stimulation
TerminatedNCT05901467
Stephanie B. Seminara, MDReproductive Disorder
Start: 2023-10-20End: 2024-05-29Updated: 2026-03-06
Dampening the Reproductive Axis With Continuous Kisspeptin
CompletedNCT05971849
Stephanie B. Seminara, MDPCOS, Polycystic Ovary Syndrome, Reproductive Disorder
Start: 2023-10-06End: 2024-04-27Updated: 2025-11-05
Kisspeptin to Quantify GnRH Neuronal Function in Health and Disease
RecruitingNCT07224490
Stephanie B. Seminara, MDNeurodegeneration, Reproductive Disorder, SARS-CoV 2
Start: 2026-03-10End: 2030-05-01Target: 40Updated: 2026-03-31

Phase 2

Administration of Kisspeptin in Patients With Hyperprolactinemia
CompletedNCT02956447
Massachusetts General HospitalHyperprolactinemia, Hypogonadism
Start: 2017-11-17End: 2023-07-29Updated: 2024-10-01
Prolonged Pulsatile Kisspeptin Administration in Hypogonadotropic Hypogonadism
CompletedNCT04648969
Stephanie B. Seminara, MDHypogonadotropic Hypogonadism
Start: 2019-05-03End: 2025-08-31Updated: 2026-02-18
Kisspeptin Administration Subcutaneously to Patients With IHH
RecruitingNCT05896293
Stephanie B. Seminara, MDHypogonadotropic Hypogonadism
Start: 2023-02-03End: 2028-05-31Target: 36Updated: 2025-10-03
Kisspeptin Administration Subcutaneously to Patients With Hypothalamic Amenorrhea
RecruitingNCT07224438
Stephanie B. Seminara, MDHypogonadotropic Hypogonadism, Hypothalamic Amenorrhea
Start: 2025-12-09End: 2030-05-31Target: 20Updated: 2025-12-31

Related Papers

Intravenous kisspeptin 112-121 bolus does not acutely impact circulating vasopressin in humans.
2025-11-22
Sex-dependent increases in oxytocin levels in response to intravenous kisspeptin in humans
European Journal of Endocrinology2025-02-187 citations
OR11-01 Using Kisspeptin to Predict Pubertal Outcomes for Youth With Pubertal Delay
Journal of the Endocrine Society2020-04-01
Divergent responses to kisspeptin in children with delayed puberty.
2018-04-1914 citations