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KHK4827

DRUG8 trials

Sponsors

Kyowa Kirin Co., Ltd., Kyowa Kirin Korea Co., Ltd.

Conditions

Moderate to Severe Plaque PsoriasisModerate to Severe Systemic SclerosisPalmoplantar PustulosisPsoriasisSystemic Sclerosis

Phase 1

A Clinical Pharmacology of KHK4827 in Healthy Volunteers and Subject With Moderate to Severe Psoriasis
CompletedNCT01488201
Kyowa Kirin Co., Ltd.Psoriasis
Start: 2011-11-30End: 2012-09-30Target: 48Updated: 2012-11-02
A Study of KHK4827 in Patients With Systemic Sclerosis
CompletedNCT04368403
Kyowa Kirin Co., Ltd.Systemic Sclerosis
Start: 2017-10-06End: 2025-03-31Updated: 2025-07-11

Phase 2

A Phase 2 Clinical Study of KHK4827
CompletedNCT01748539
Kyowa Kirin Co., Ltd.Moderate to Severe Plaque Psoriasis
Start: 2012-12-31End: 2013-09-30Target: 140Updated: 2013-09-05

Phase 3

A Phase 3 Clinical Study of KHK4827
CompletedNCT01782924
Kyowa Kirin Co., Ltd.Psoriasis
Start: 2013-03-31End: 2015-02-28Updated: 2015-02-16
An Open-label, Non-controlled Study of KHK4827 in Subjects With Psoriasis
CompletedNCT01782937
Kyowa Kirin Co., Ltd.Psoriasis
Start: 2013-02-28End: 2014-12-31Updated: 2015-02-16
A Study of KHK4827 (Brodalumab) in Subjects With Moderate to Severe Psoriasis in Korea
CompletedNCT02982005
Kyowa Kirin Korea Co., Ltd.Moderate to Severe Plaque Psoriasis
Start: 2017-01-31End: 2018-08-14Updated: 2024-04-29
A Phase 3 Study of KHK4827 in Patients With Systemic Sclerosis
CompletedNCT03957681
Kyowa Kirin Co., Ltd.Moderate to Severe Systemic Sclerosis
Start: 2019-05-23End: 2025-04-11Updated: 2025-07-11
A Study of KHK4827 in Subjects With Palmoplantar Pustulosis
CompletedNCT04061252
Kyowa Kirin Co., Ltd.Palmoplantar Pustulosis
Start: 2019-08-10End: 2022-08-05Updated: 2023-02-14

Related Papers

Exploratory MRI and Clinical Marker Analysis of Pustulotic Arthro-Osteitis Disease Activity From a Phase 3 Brodalumab Trial.
2026-08-02
Efficacy and Safety of Brodalumab, an Anti-interleukin-17 Receptor A Monoclonal Antibody, for Palmoplantar Pustulosis: 16-Week Results of a Randomized Clinical Trial
American Journal of Clinical Dermatology2024-07-0219 citations