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Ketamine + Naltrexone
DRUG
2 trials
Sponsors
VA Office of Research and Development
, VA Connecticut Healthcare System
Conditions
Alcohol Use Disorder
Major Depressive Disorder
Phase 1
Ketamine for the Rapid Treatment of Major Depressive Disorder and Alcohol Use Disorder
Completed
NCT02461927
VA Office of Research and Development
Alcohol Use Disorder, Major Depressive Disorder
Start: 2015-01-01
End: 2023-10-30
Updated: 2025-04-10
Phase 2
Naltrexone Plus Ketamine for the Rapid Treatment of Major Depressive Disorder and Alcohol Use Disorder
Completed
NCT03658330
VA Connecticut Healthcare System
Alcohol Use Disorder, Major Depressive Disorder
Start: 2016-05-31
End: 2018-06-30
Updated: 2018-09-07
Related Papers
Antidepressant efficacy of ketamine plus naltrexone for major depression comorbid with alcohol use disorder: a randomized controlled trial
The International Journal of Neuropsychopharmacology
2025-08-01
2 citations
Neural Mechanisms Underlying the Rewarding and Therapeutic Effects of Ketamine as a Treatment for Alcohol Use Disorder
Frontiers in Behavioral Neuroscience
2020-12-10
17 citations