JNJ-73841937
Sponsors
Janssen - Cilag International, Janssen Cilag International, ETOP IBCSG Partners Foundation
Conditions
Advanced or Metastatic Solid Tumors including EGFR-mutated Non-Small Cell Lung Cancer.Common EGFR-Mutated Locally Advanced or Metastatic Non-Small Cell Lung CancerEGFR-mutated Advanced or Metastatic Non-small Cell Lung CancerEGFR-mutated locally advanced or metastatic Non Small Cell Lung CancerLocally Advanced or Metastatic Non-Small Cell Lung CancerPatients with EGFR-mutant (L858R or del19 only) advanced non-squamous NSCLCwho have progressed on previous treatment with a third-generation EGFR-TKI.
Phase 2
Subcutaneous Methotrexate, Oral Dexamethasone or Oral Montelukast for the Prevention
of Infusion Related Reaction Associated with Amivantamab, an EGFR-MET bispecific
antibody, Among Post-osimertinib Treated EGFRm NSCLC; SKIPPirr, a Phase 2 Study
Active, not recruitingCTIS2023-506578-11-00
Start: 2023-04-25Target: 60Updated: 2025-11-07
A Phase 2, open-label, randomized trial evaluating the impact of enhanced versus standard dermatologic management on selected dermatologic adverse events among patients with locally advanced or metastatic EGFR-mutated NSCLC treated first-line with amivantamab + lazertinib
RecruitingCTIS2023-505863-35-00
Start: 2024-03-20Target: 15Updated: 2025-10-27
A Phase 2, Open-Label, Parallel Cohort Study of Subcutaneous Amivantamab in Multiple
Regimens in Patients with Advanced or Metastatic Solid Tumors including EGFR-mutated
Non-Small Cell Lung Cancer
RecruitingCTIS2023-505065-91-00
Start: 2023-01-30Target: 98Updated: 2025-11-14
ETOP 18-21 AMAZE-lung: A multicentre single-arm phase II trial of amivantamab, lazertinib plus bevacizumab in patients with EGFR-mutant advanced NSCLC with progression on previous third-generation EGFR-TKI.
Active, not recruitingCTIS2024-512288-29-00
Start: 2023-04-11Target: 30Updated: 2025-06-06
A Phase 2b, Open-Label, Two-cohort Study of Subcutaneous Amivantamab in Combination with Lazertinib as First-Line Treatment, or Subcutaneous Amivantamab in Combination with Platinum-Based Chemotherapy as Second-line Treatment, for Common EGFR-Mutated Locally Advanced or Metastatic Non-Small Cell Lung Cancer
RecruitingCTIS2025-520730-28-00
Start: 2025-12-08Target: 118Updated: 2025-12-23
Phase 3
A Phase 3, Open-Label, Randomized Study of Amivantamab and Lazertinib in
Combination with Platinum-Based Chemotherapy Compared with Platinum-Based
Chemotherapy in Patients with EGFR-Mutated Locally Advanced or Metastatic Non-
Small Cell Lung Cancer After Osimertinib Failure
Active, not recruitingCTIS2023-506518-33-00
Start: 2021-11-10Target: 259Updated: 2025-11-13
A Phase 3, Randomized Study of Amivantamab and Lazertinib Combination Therapy
Versus Osimertinib Versus Lazertinib as First-Line Treatment in Patients with
EGFR-Mutated Locally Advanced or Metastatic Non-Small Cell Lung Cancer
Active, not recruitingCTIS2023-506576-27-00
Start: 2020-09-30Target: 170Updated: 2025-11-10
A Phase 3, Open-label, Randomized Study of Lazertinib with Subcutaneous Amivantamab Compared with Intravenous Amivantamab in Patients with EGFR-mutated Advanced or Metastatic Non-small Cell Lung Cancer After Progression on Osimertinib and Chemotherapy
Active, not recruitingCTIS2024-512045-16-00
Start: 2022-08-18Target: 76Updated: 2025-12-05