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JNJ-73841937

DRUG8 trials

Sponsors

Janssen - Cilag International, Janssen Cilag International, ETOP IBCSG Partners Foundation

Conditions

Advanced or Metastatic Solid Tumors including EGFR-mutated Non-Small Cell Lung Cancer.Common EGFR-Mutated Locally Advanced or Metastatic Non-Small Cell Lung CancerEGFR-mutated Advanced or Metastatic Non-small Cell Lung CancerEGFR-mutated locally advanced or metastatic Non Small Cell Lung CancerLocally Advanced or Metastatic Non-Small Cell Lung CancerPatients with EGFR-mutant (L858R or del19 only) advanced non-squamous NSCLCwho have progressed on previous treatment with a third-generation EGFR-TKI.

Phase 2

Subcutaneous Methotrexate, Oral Dexamethasone or Oral Montelukast for the Prevention of Infusion Related Reaction Associated with Amivantamab, an EGFR-MET bispecific antibody, Among Post-osimertinib Treated EGFRm NSCLC; SKIPPirr, a Phase 2 Study
Active, not recruitingCTIS2023-506578-11-00
Janssen - Cilag InternationalEGFR-mutated Advanced or Metastatic Non-small Cell Lung Cancer
Start: 2023-04-25Target: 60Updated: 2025-11-07
A Phase 2, open-label, randomized trial evaluating the impact of enhanced versus standard dermatologic management on selected dermatologic adverse events among patients with locally advanced or metastatic EGFR-mutated NSCLC treated first-line with amivantamab + lazertinib
RecruitingCTIS2023-505863-35-00
Janssen - Cilag InternationalEGFR-mutated Advanced or Metastatic Non-small Cell Lung Cancer
Start: 2024-03-20Target: 15Updated: 2025-10-27
A Phase 2, Open-Label, Parallel Cohort Study of Subcutaneous Amivantamab in Multiple Regimens in Patients with Advanced or Metastatic Solid Tumors including EGFR-mutated Non-Small Cell Lung Cancer
RecruitingCTIS2023-505065-91-00
Janssen - Cilag InternationalAdvanced or Metastatic Solid Tumors including EGFR-mutated Non-Small Cell Lung Cancer.
Start: 2023-01-30Target: 98Updated: 2025-11-14
ETOP 18-21 AMAZE-lung: A multicentre single-arm phase II trial of amivantamab, lazertinib plus bevacizumab in patients with EGFR-mutant advanced NSCLC with progression on previous third-generation EGFR-TKI.
Active, not recruitingCTIS2024-512288-29-00
ETOP IBCSG Partners FoundationPatients with EGFR-mutant (L858R or del19 only) advanced non-squamous NSCLC, who have progressed on previous treatment with a third-generation EGFR-TKI.
Start: 2023-04-11Target: 30Updated: 2025-06-06
A Phase 2b, Open-Label, Two-cohort Study of Subcutaneous Amivantamab in Combination with Lazertinib as First-Line Treatment, or Subcutaneous Amivantamab in Combination with Platinum-Based Chemotherapy as Second-line Treatment, for Common EGFR-Mutated Locally Advanced or Metastatic Non-Small Cell Lung Cancer
RecruitingCTIS2025-520730-28-00
Janssen Cilag InternationalCommon EGFR-Mutated Locally Advanced or Metastatic Non-Small Cell Lung Cancer
Start: 2025-12-08Target: 118Updated: 2025-12-23

Phase 3