JNJ-64407564
Sponsors
Janssen - Cilag International, European Myeloma Network B.V., Emn Trial Office S.r.l. Impresa Sociale, North Estonia Medical Centre Foundation, Centre Hospitalier Universitaire De Nantes, Universitaetsklinikum Heidelberg AöR
Conditions
Multiple MyelomaMultiple myelomaNewly Diagnosed Multiple MyelomaNewly Diagnosed Multiple Myeloma in patients eligible for stem cell transplantationRelapsed or Refractory Multiple MyelomaRelapsed or Refractory Myelomamultiple myeloma
Phase 1
A Phase 1/2, First-in-Human, Open-Label, Dose Escalation Study of Talquetamab, a Humanized GPRC5D x CD3 Bispecific Antibody, in Subjects with Relapsed or Refractory Multiple Myeloma
Active, not recruitingCTIS2023-504581-29-00
Start: 2018-04-26Target: 291Updated: 2025-12-22
A Phase 1b/2 Dose Escalation and Expansion Study of the Combination of the Bispecific
T Cell Redirection Antibodies Talquetamab and Teclistamab in Participants with Relapsed
or Refractory Multiple Myeloma
Active, not recruitingCTIS2023-503439-16-00
Start: 2020-12-29Target: 51Updated: 2025-03-10
Phase 2
A Phase 2, Multi-cohort Study Applying Innovative MRD Techniques for Transplant Eligible Participants with Previously Untreated Multiple Myeloma - TAURUS
RecruitingCTIS2023-505221-14-00
Start: 2023-12-04Target: 237Updated: 2026-01-26
TALTEC: A phase II study measuring MRD negativity after bispecific T-cell redirectors TALquetamab and TEClistamab consolidation as part of first line treatment in transplant eligible multiple myeloma patients
Active, not recruitingCTIS2023-508212-38-00
Start: 2024-06-11Target: 50Updated: 2025-09-12
Minimal Residual Disease-based Strategy with T-Cell Redirector After Treatment with Daratumumab, Bortezomib, Lenalidomide, and Dexamethasone (D-VRd) in Newly Diagnosed Multiple Myeloma: A Phase 2 (IFM 2022-01).
Active, not recruitingCTIS2023-508310-41-00
Start: 2024-06-26Target: 103Updated: 2025-11-03
A Phase 2, Open-label, Randomized Study to Evaluate Prophylactic Interventions on Talquetamab-related Oral Toxicity
RecruitingCTIS2023-506260-14-00
Start: 2025-05-13Target: 60Updated: 2025-09-17
A Phase 2 Study to Evaluate Safety and Efficacy of Teclistamab-,Talquetamab- and JNJ-79635322-based Combination Regimens in Participants with Newly Diagnosed Transplant Eligible Multiple Myeloma
RecruitingCTIS2024-517382-17-00
Start: 2022-11-30Target: 130Updated: 2025-08-19
EFfIcacy and Tolerability of FIXed duration teclistamab and talquetamab FOR FRAIL patients with newly diagnosed multiple myeloma (2 cohort study) - the EMN 37 FITFIX FOR FRAIL trial
RecruitingCTIS2024-520433-76-00
Start: 2026-01-08Target: 150Updated: 2026-01-15
Phase 3
A Phase 3 Randomized Study Comparing Talquetamab in Combination with Pomalidomide (Tal-P), Talquetamab in Combination with Teclistamab (Tal-Tec), and Investigator’s Choice of Either Elotuzumab, Pomalidomide, and Dexamethasone (EPd) or Pomalidomide, Bortezomib, and Dexamethasone (PVd) in Participants with Relapsed or Refractory Myeloma who Have Received 1 to 4 Prior Lines of Therapy Including an Anti-CD38 Antibody and Lenalidomide
Active, not recruitingCTIS2022-502446-27-00
Start: 2024-02-26Target: 453Updated: 2026-01-13
A Phase 3 Randomized Study Comparing Talquetamab SC in Combination With Daratumumab SC and Pomalidomide (Tal-DP) or Talquetamab SC in Combination With Daratumumab SC (Tal-D) Versus Daratumumab SC, Pomalidomide and Dexamethasone (DPd), in Participants With Relapsed or Refractory Multiple Myeloma who Have Received at Least 1 Prior Line of Therapy
Active, not recruitingCTIS2023-503467-41-00
Start: 2022-10-12Target: 310Updated: 2026-01-27
A Phase 3 Randomized Study Comparing Teclistamab in Combination with Daratumumab SC and Lenalidomide (Tec-DR) and Talquetamab in Combination with Daratumumab SC and Lenalidomide (Tal-DR) versus Daratumumab SC, Lenalidomide, and Dexamethasone (DRd) in Participants with Newly Diagnosed Multiple Myeloma Who are Either Ineligible or not Intended for Autologous Stem Cell Transplant as Initial Therapy
RecruitingCTIS2023-503442-30-00
Start: 2022-10-14Target: 563Updated: 2025-09-02