JNJ-63723283
Sponsors
Janssen - Cilag International, Janssen Cilag International, Grupo Espanol De Oncologia Genitourinaria-Socug, Universitair Medisch Centrum Groningen, Janssen Research & Development, LLC
Conditions
Advanced Stage Solid TumorsHigh-Risk Non-muscle-invasive Bladder CancerMetastatic Non-small Cell Lung CancerMetastatic or Locally Advanced Urothelial CancerMultiple MyelomaMuscle-Invasive Urothelial Carcinoma (MIBC) of the BladderMuscle-Invasive Urothelial Carcinoma of the BladderMuscle-invasive bladder cancer (MIBC)
Phase 1
A Study to Evaluate the Safety, Pharmacokinetics, Pharmacodynamics, and Clinical Activity of JNJ-63723283, an Anti-PD-1 Monoclonal Antibody, in Participants With Advanced Cancers
Active, not recruitingNCT02908906
Start: 2016-11-21End: 2026-12-31Updated: 2026-03-12
A Study to Evaluate the Safety, Pharmacokinetics, Pharmacodynamics, and Immunogenicity of JNJ-63723283, an Anti-Programmed Cell Death (PD)-1 Monoclonal Antibody, as Monotherapy or in Combination With Erdafitinib in Japanese Participants With Advanced Solid Cancers
CompletedNCT03547037
Start: 2018-08-31End: 2022-07-04Updated: 2025-04-28
A Phase 1b-2 Study to Evaluate Safety, Efficacy, Pharmacokinetics, and
Pharmacodynamics of Various Regimens of Erdafitinib in Subjects with Metastatic or
Locally Advanced Urothelial Cancer
Active, not recruitingCTIS2023-510295-31-00
Start: 2018-09-24Target: 7Updated: 2025-08-20
A First-in-Human, Open-label, Phase 1/2 Study to Evaluate the Safety, Pharmacokinetics, Pharmacodynamics, and Clinical Activity of JNJ-63723283, an Anti-PD-1 Monoclonal Antibody, in Subjects with Advanced Cancers
Active, not recruitingCTIS2023-506144-16-00
Start: 2016-12-06Target: 3Updated: 2025-03-16
Investigation-specific Appendix 2to Master Protocol PLATFORMPANSC2001 (KALEIDOSCOPE) A Phase 1/2 Study Evaluating the Safety and Efficacy of Amivantamab and Cetrelimab Combination Therapy in Metastatic Non-small Cell Lung Cancer - PolyDamas
Active, not recruitingCTIS2022-501452-29-00
Start: 2024-08-28Target: 26Updated: 2025-11-28
CD8 PET imaging in metastatic solid tumours; A phase II, open label, multi-center study of 89Zr-DF-crefmirlimab for CD8 positron emission tomography in patients with locally advanced or metastatic solid tumors
RecruitingCTIS2024-515885-15-00
Start: 2025-03-04Target: 16Updated: 2025-09-22
Phase 2
A Study of JNJ-63723283, an Anti-programmed Death-1 Monoclonal Antibody, Administered in Combination With Daratumumab, Compared With Daratumumab Alone in Participants With Relapsed or Refractory Multiple Myeloma
CompletedNCT03357952
Start: 2017-11-16End: 2021-11-19Updated: 2025-02-04
A Phase 2, Open-Label, Multi-Center, Randomized Study of TAR-200 in Combination with Cetrelimab and Cetrelimab Alone in Participants with Muscle-Invasive Urothelial Carcinoma of the Bladder who are Scheduled for Radical Cystectomy and are Ineligible for or Refusing Platinum-Based Neoadjuvant Chemotherapy
Active, not recruitingCTIS2023-507189-17-00
Start: 2022-01-09Target: 89Updated: 2025-10-10
Phase 2b Clinical Study Evaluating Efficacy and Safety of TAR-200 in Combination with
Cetrelimab, TAR-200 Alone, or Cetrelimab Alone in Participants with High-Risk Non-
Muscle Invasive Bladder Cancer (NMIBC) Unresponsive to Intravesical Bacillus Calmette-
Guérin (BCG) who are Ineligible for or Elected Not to Undergo Radical Cystectomy
Active, not recruitingCTIS2023-506146-23-00
Start: 2025-11-17Target: 130Updated: 2025-10-29
A Phase 2, open-label, multi-centre, multi-national interventional trial to evaluate the efficacy and safety of erdafitinib (ERDA) monotherapy and erdafitinib (ERDA) and cetrelimab (CET) combination as neoadjuvant treatment in cisplatin-ineligible patients with muscle-invasive bladder cancer (MIBC) whose tumours express FGFR gene alterations (SOGUG-NEOWIN)
RecruitingCTIS2024-512573-27-01
Start: 2023-12-11Target: 62Updated: 2025-09-02
Phase 3
A Phase 3, Open-Label, Multi-Center, Randomized Study Evaluating the Efficacy and Safety of TAR-200 in Combination with Cetrelimab or TAR-200 Alone Versus Intravesical Bacillus Calmette-Guérin (BCG) in Participants with BCG-naïve High-Risk Non-Muscle Invasive Bladder Cancer (HRNMIBC)
Active, not recruitingCTIS2023-507187-39-00
Start: 2023-03-23Target: 391Updated: 2025-09-09
A Phase 3, Multi-center, Randomized Study Evaluating Efficacy of TAR-200 in
Combination With Cetrelimab Versus Concurrent Chemoradiotherapy in Participants
With Muscle-Invasive Urothelial Carcinoma (MIBC) of the Bladder who are not Receiving
Radical Cystectomy
Active, not recruitingCTIS2023-507188-21-00
Start: 2021-04-20Target: 171Updated: 2025-09-25