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JNJ-61186372

DRUG20 trials

Sponsors

Gruppo Oncologico Del Nord Ovest, Janssen - Cilag International, Janssen Cilag International, Het Nederlands Kanker Instituut-Antoni van Leeuwenhoek Ziekenhuis Stichting, ETOP IBCSG Partners Foundation

Conditions

Advanced or Metastatic Colorectal CancerAdvanced or Metastatic Solid Tumors including EGFR-mutated Non-Small Cell Lung Cancer.Advanced solid tumorCommon EGFR-Mutated Locally Advanced or Metastatic Non-Small Cell Lung CancerEGFR Exon 20ins Mutated Locally Advanced or Metastatic Non-Small Cell Lung CancerEGFR-mutated Advanced or Metastatic Non-small Cell Lung CancerEGFR-mutated locally advanced or metastatic Non Small Cell Lung CancerHead and Neck Squamous Cell Carcinoma

Phase 1

Phase 2

WINDOW-OF-OPPORTUNITY UMBRELLA PLATFORM TRIAL OF SHORT-COURSE PRE-OPERATIVE OR NEOADJUVANT TARGETED TREATMENT IN PATIENTS WITH MOLECULARLY SELECTED AND RESECTABLE PRIMARY COLORECTAL CANCER: THE UNICORN STUDY
RecruitingCTIS2022-501308-90-00
Gruppo Oncologico Del Nord OvestMolecularly selected and resectable primary colorectal cancer
Start: 2023-05-24Target: 112Updated: 2025-10-07
Subcutaneous Methotrexate, Oral Dexamethasone or Oral Montelukast for the Prevention of Infusion Related Reaction Associated with Amivantamab, an EGFR-MET bispecific antibody, Among Post-osimertinib Treated EGFRm NSCLC; SKIPPirr, a Phase 2 Study
Active, not recruitingCTIS2023-506578-11-00
Janssen - Cilag InternationalEGFR-mutated Advanced or Metastatic Non-small Cell Lung Cancer
Start: 2023-04-25Target: 60Updated: 2025-11-07
A Phase 2, open-label, randomized trial evaluating the impact of enhanced versus standard dermatologic management on selected dermatologic adverse events among patients with locally advanced or metastatic EGFR-mutated NSCLC treated first-line with amivantamab + lazertinib
RecruitingCTIS2023-505863-35-00
Janssen - Cilag InternationalEGFR-mutated Advanced or Metastatic Non-small Cell Lung Cancer
Start: 2024-03-20Target: 15Updated: 2025-10-27
A Dutch National Study on behalf of the Center for Personalized Cancer Treatment (CPCT) to Facilitate Patient Access to Commercially Available, Targeted Anti-cancer Drugs to determine the Potential Efficacy in Treatment of Advanced Cancers with a Known Molecular Profile: The Drug Rediscovery Protocol (DRUP trial)
RecruitingCTIS2023-509152-33-00
Het Nederlands Kanker Instituut-Antoni van Leeuwenhoek Ziekenhuis StichtingAdvanced solid tumor, Multiple myeloma, Non-Hodgkin lymphoma +1
Start: 2016-07-25Target: 3000Updated: 2025-12-19
A Phase 2, Open-Label, Parallel Cohort Study of Subcutaneous Amivantamab in Multiple Regimens in Patients with Advanced or Metastatic Solid Tumors including EGFR-mutated Non-Small Cell Lung Cancer
RecruitingCTIS2023-505065-91-00
Janssen - Cilag InternationalAdvanced or Metastatic Solid Tumors including EGFR-mutated Non-Small Cell Lung Cancer.
Start: 2023-01-30Target: 98Updated: 2025-11-14
Basket of Baskets: A Modular, Open-label, Phase II, Multicentre Study To Evaluate Targeted Agents in Molecularly Selected Populations With Advanced Solid Tumours
RecruitingCTIS2024-514238-19-00
Vall D Hebron Institute Of OncologySubjects with advanced solid tumour
Start: 2018-03-28Target: 167Updated: 2025-12-31
ETOP 18-21 AMAZE-lung: A multicentre single-arm phase II trial of amivantamab, lazertinib plus bevacizumab in patients with EGFR-mutant advanced NSCLC with progression on previous third-generation EGFR-TKI.
Active, not recruitingCTIS2024-512288-29-00
ETOP IBCSG Partners FoundationPatients with EGFR-mutant (L858R or del19 only) advanced non-squamous NSCLC, who have progressed on previous treatment with a third-generation EGFR-TKI.
Start: 2023-04-11Target: 30Updated: 2025-06-06
Phase II trial of amivantamab plus monochemotherapy in platinum unfit NSCLC patients with EGFR exon20 insertion mutations
Not yet recruitingCTIS2025-520676-26-00
Fondazione Ricerca TraslazionaleNon-small cell lung cancer (NSCLC)
Target: 35Updated: 2025-10-24
A Phase 2b, Open-Label, Two-cohort Study of Subcutaneous Amivantamab in Combination with Lazertinib as First-Line Treatment, or Subcutaneous Amivantamab in Combination with Platinum-Based Chemotherapy as Second-line Treatment, for Common EGFR-Mutated Locally Advanced or Metastatic Non-Small Cell Lung Cancer
RecruitingCTIS2025-520730-28-00
Janssen Cilag InternationalCommon EGFR-Mutated Locally Advanced or Metastatic Non-Small Cell Lung Cancer
Start: 2025-12-08Target: 118Updated: 2025-12-23

Phase 3

A Phase 3, Open-Label, Randomized Study of Amivantamab and Lazertinib in Combination with Platinum-Based Chemotherapy Compared with Platinum-Based Chemotherapy in Patients with EGFR-Mutated Locally Advanced or Metastatic Non- Small Cell Lung Cancer After Osimertinib Failure
Active, not recruitingCTIS2023-506518-33-00
Janssen - Cilag InternationalLocally Advanced or Metastatic Non-Small Cell Lung Cancer
Start: 2021-11-10Target: 259Updated: 2025-11-13
A Randomized, Open-label Phase 3 Study of Combination Amivantamab and Carboplatin-Pemetrexed Therapy, Compared with Carboplatin-Pemetrexed, in Patients with EGFR Exon 20ins Mutated Locally Advanced or Metastatic Non-Small Cell Lung Cancer
Active, not recruitingCTIS2023-506033-29-00
Janssen - Cilag InternationalEGFR Exon 20ins Mutated Locally Advanced or Metastatic Non-Small Cell Lung Cancer
Start: 2020-10-09Target: 64Updated: 2025-12-17
A Phase 3, Randomized Study of Amivantamab and Lazertinib Combination Therapy Versus Osimertinib Versus Lazertinib as First-Line Treatment in Patients with EGFR-Mutated Locally Advanced or Metastatic Non-Small Cell Lung Cancer
Active, not recruitingCTIS2023-506576-27-00
Janssen - Cilag InternationalEGFR-mutated locally advanced or metastatic Non Small Cell Lung Cancer
Start: 2020-09-30Target: 170Updated: 2025-11-10
A Phase 3, Open-label, Randomized Study of Lazertinib with Subcutaneous Amivantamab Compared with Intravenous Amivantamab in Patients with EGFR-mutated Advanced or Metastatic Non-small Cell Lung Cancer After Progression on Osimertinib and Chemotherapy
Active, not recruitingCTIS2024-512045-16-00
Janssen Cilag InternationalEGFR-mutated Advanced or Metastatic Non-small Cell Lung Cancer
Start: 2022-08-18Target: 76Updated: 2025-12-05
A Randomized, Open-label Phase 3 Study of Amivantamab and mFOLFOX6 or FOLFIRI Versus Cetuximab and mFOLFOX6 or FOLFIRI as First-line Treatment in Participants With KRAS/NRAS and BRAF Wild-type Unresectable or Metastatic Left-sided Colorectal Cancer
RecruitingCTIS2024-513852-13-00
Janssen Cilag InternationalKRAS/NRAS and BRAF Wild-type Unresectable or Metastatic Left-sided Colorectal Cancer
Start: 2025-01-20Target: 266Updated: 2025-12-22
A Randomized, Open-label Phase 3 Study of Amivantamab + FOLFIRI Versus Cetuximab/Bevacizumab + FOLFIRI in Participants With KRAS/NRAS and BRAF Wildtype Recurrent, Unresectable or Metastatic Colorectal Cancer Who Have Received Prior Chemotherapy
RecruitingCTIS2024-513853-66-00
Janssen Cilag InternationalKRAS/NRAS and BRAF Wildtype Recurrent, Unresectable or Metastatic Colorectal Cancer
Start: 2025-02-04Target: 162Updated: 2026-01-07
A Phase 3, Randomized, Open-Label, Multicenter Study of Amivantamab in Addition to Carboplatin and Pembrolizumab, Compared to Standard of Care Platinum and Pembrolizumab and 5-FU, in Participants with Treatment-Naïve Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma
RecruitingCTIS2025-521917-24-00
Janssen Cilag InternationalTreatment-Naïve Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma
Start: 2026-01-21Target: 192Updated: 2026-01-19

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