JNJ-61186372
Sponsors
Gruppo Oncologico Del Nord Ovest, Janssen - Cilag International, Janssen Cilag International, Het Nederlands Kanker Instituut-Antoni van Leeuwenhoek Ziekenhuis Stichting, ETOP IBCSG Partners Foundation
Conditions
Advanced or Metastatic Colorectal CancerAdvanced or Metastatic Solid Tumors including EGFR-mutated Non-Small Cell Lung Cancer.Advanced solid tumorCommon EGFR-Mutated Locally Advanced or Metastatic Non-Small Cell Lung CancerEGFR Exon 20ins Mutated Locally
Advanced or Metastatic Non-Small Cell Lung CancerEGFR-mutated Advanced or Metastatic Non-small Cell Lung CancerEGFR-mutated locally advanced or metastatic Non Small Cell Lung CancerHead and Neck Squamous Cell Carcinoma
Phase 1
A Phase 1b/2, Open-Label Study of Amivantamab Monotherapy and in Addition to Standard-of-Care Chemotherapy in Participants with Advanced or Metastatic Colorectal Cancer
RecruitingCTIS2023-506517-22-00
Start: 2022-08-31Target: 37Updated: 2025-12-12
Investigation-specific Appendix 1 to Master Protocol PLATFORMPANSC2001
(KALEIDOSCOPE)
A Phase 1/2 Study Evaluating the Safety and Efficacy of Amivantamab and Capmatinib
Combination Therapy in Unresectable Metastatic Non-small Cell Lung Cancer - METalmark
Active, not recruitingCTIS2023-508256-19-00
Start: 2024-07-15Target: 38Updated: 2025-12-22
A Phase 1b/2, Open-label Study of Amivantamab Monotherapy and Amivantamab in Addition to Other Therapeutic Agents in Participants with Head and Neck Squamous Cell Carcinoma
OrigAMI-4
RecruitingCTIS2023-508418-40-00
Start: 2024-12-16Target: 55Updated: 2026-01-19
Investigation-specific Appendix 2to Master Protocol PLATFORMPANSC2001 (KALEIDOSCOPE) A Phase 1/2 Study Evaluating the Safety and Efficacy of Amivantamab and Cetrelimab Combination Therapy in Metastatic Non-small Cell Lung Cancer - PolyDamas
Active, not recruitingCTIS2022-501452-29-00
Start: 2024-08-28Target: 26Updated: 2025-11-28
Phase 2
WINDOW-OF-OPPORTUNITY UMBRELLA PLATFORM TRIAL OF SHORT-COURSE PRE-OPERATIVE OR NEOADJUVANT TARGETED TREATMENT IN PATIENTS WITH MOLECULARLY SELECTED AND RESECTABLE PRIMARY COLORECTAL CANCER: THE UNICORN STUDY
RecruitingCTIS2022-501308-90-00
Start: 2023-05-24Target: 112Updated: 2025-10-07
Subcutaneous Methotrexate, Oral Dexamethasone or Oral Montelukast for the Prevention
of Infusion Related Reaction Associated with Amivantamab, an EGFR-MET bispecific
antibody, Among Post-osimertinib Treated EGFRm NSCLC; SKIPPirr, a Phase 2 Study
Active, not recruitingCTIS2023-506578-11-00
Start: 2023-04-25Target: 60Updated: 2025-11-07
A Phase 2, open-label, randomized trial evaluating the impact of enhanced versus standard dermatologic management on selected dermatologic adverse events among patients with locally advanced or metastatic EGFR-mutated NSCLC treated first-line with amivantamab + lazertinib
RecruitingCTIS2023-505863-35-00
Start: 2024-03-20Target: 15Updated: 2025-10-27
A Dutch National Study on behalf of the Center for Personalized Cancer Treatment (CPCT) to Facilitate Patient Access to Commercially Available, Targeted Anti-cancer Drugs to determine the Potential Efficacy in Treatment of Advanced Cancers with a Known Molecular Profile: The Drug Rediscovery Protocol (DRUP trial)
RecruitingCTIS2023-509152-33-00
Start: 2016-07-25Target: 3000Updated: 2025-12-19
A Phase 2, Open-Label, Parallel Cohort Study of Subcutaneous Amivantamab in Multiple
Regimens in Patients with Advanced or Metastatic Solid Tumors including EGFR-mutated
Non-Small Cell Lung Cancer
RecruitingCTIS2023-505065-91-00
Start: 2023-01-30Target: 98Updated: 2025-11-14
Basket of Baskets: A Modular, Open-label, Phase II, Multicentre Study To Evaluate Targeted Agents in Molecularly Selected Populations With Advanced Solid Tumours
RecruitingCTIS2024-514238-19-00
Start: 2018-03-28Target: 167Updated: 2025-12-31
ETOP 18-21 AMAZE-lung: A multicentre single-arm phase II trial of amivantamab, lazertinib plus bevacizumab in patients with EGFR-mutant advanced NSCLC with progression on previous third-generation EGFR-TKI.
Active, not recruitingCTIS2024-512288-29-00
Start: 2023-04-11Target: 30Updated: 2025-06-06
Phase II trial of amivantamab plus monochemotherapy in platinum unfit NSCLC patients with EGFR exon20 insertion mutations
Not yet recruitingCTIS2025-520676-26-00
Target: 35Updated: 2025-10-24
A Phase 2b, Open-Label, Two-cohort Study of Subcutaneous Amivantamab in Combination with Lazertinib as First-Line Treatment, or Subcutaneous Amivantamab in Combination with Platinum-Based Chemotherapy as Second-line Treatment, for Common EGFR-Mutated Locally Advanced or Metastatic Non-Small Cell Lung Cancer
RecruitingCTIS2025-520730-28-00
Start: 2025-12-08Target: 118Updated: 2025-12-23
Phase 3
A Phase 3, Open-Label, Randomized Study of Amivantamab and Lazertinib in
Combination with Platinum-Based Chemotherapy Compared with Platinum-Based
Chemotherapy in Patients with EGFR-Mutated Locally Advanced or Metastatic Non-
Small Cell Lung Cancer After Osimertinib Failure
Active, not recruitingCTIS2023-506518-33-00
Start: 2021-11-10Target: 259Updated: 2025-11-13
A Randomized, Open-label Phase 3 Study of Combination Amivantamab and Carboplatin-Pemetrexed Therapy, Compared with Carboplatin-Pemetrexed, in Patients with EGFR Exon 20ins Mutated Locally Advanced or Metastatic Non-Small Cell Lung Cancer
Active, not recruitingCTIS2023-506033-29-00
Start: 2020-10-09Target: 64Updated: 2025-12-17
A Phase 3, Randomized Study of Amivantamab and Lazertinib Combination Therapy
Versus Osimertinib Versus Lazertinib as First-Line Treatment in Patients with
EGFR-Mutated Locally Advanced or Metastatic Non-Small Cell Lung Cancer
Active, not recruitingCTIS2023-506576-27-00
Start: 2020-09-30Target: 170Updated: 2025-11-10
A Phase 3, Open-label, Randomized Study of Lazertinib with Subcutaneous Amivantamab Compared with Intravenous Amivantamab in Patients with EGFR-mutated Advanced or Metastatic Non-small Cell Lung Cancer After Progression on Osimertinib and Chemotherapy
Active, not recruitingCTIS2024-512045-16-00
Start: 2022-08-18Target: 76Updated: 2025-12-05
A Randomized, Open-label Phase 3 Study of Amivantamab and mFOLFOX6 or FOLFIRI
Versus Cetuximab and mFOLFOX6 or FOLFIRI as First-line Treatment in Participants
With KRAS/NRAS and BRAF Wild-type Unresectable or Metastatic Left-sided Colorectal Cancer
RecruitingCTIS2024-513852-13-00
Start: 2025-01-20Target: 266Updated: 2025-12-22
A Randomized, Open-label Phase 3 Study of Amivantamab + FOLFIRI Versus
Cetuximab/Bevacizumab + FOLFIRI in Participants With KRAS/NRAS and BRAF Wildtype
Recurrent, Unresectable or Metastatic Colorectal Cancer Who Have Received Prior
Chemotherapy
RecruitingCTIS2024-513853-66-00
Start: 2025-02-04Target: 162Updated: 2026-01-07
A Phase 3, Randomized, Open-Label, Multicenter Study of Amivantamab in Addition to
Carboplatin and Pembrolizumab, Compared to Standard of Care Platinum and
Pembrolizumab and 5-FU, in Participants with Treatment-Naïve Recurrent/Metastatic
Head and Neck Squamous Cell Carcinoma
RecruitingCTIS2025-521917-24-00
Start: 2026-01-21Target: 192Updated: 2026-01-19