JNJ-56136379
Sponsors
Janssen Sciences Ireland UC, Janssen Research & Development, LLC, Arrowhead Pharmaceuticals
Conditions
HealthyHepatic ImpairmentHepatitis BHepatitis B, ChronicHepatitis, ChronicRenal Insufficiency
Phase 1
A Study of Orally Administered JNJ-56136379 to Evaluate Safety, Tolerability and Pharmacokinetics After Single Ascending Doses and One Multiple Dose Regimen in Healthy Participants (Part I), and After Multiple Dose Regimens in Participants With Chronic Hepatitis B (Part II)
CompletedNCT02662712
Start: 2015-12-17End: 2018-06-29Updated: 2025-02-03
A Study to Investigate Safety, Tolerability, and Pharmacokinetics of JNJ-56136379 in Healthy Japanese Adult Participants
CompletedNCT02933580
Start: 2016-10-12End: 2017-02-04Updated: 2018-03-16
A Study in Healthy Female Participants to Investigate the Effect of JNJ-56136379 at Steady-state on the Single-dose Pharmacokinetics of Ethinylestradiol and Drospirenone (Oral Contraceptive) and on the Single-dose Pharmacokinetics of Midazolam (Probe Substrate for Cytochrome P450 3A4)
CompletedNCT03111511
Start: 2017-03-27End: 2017-08-23Updated: 2017-09-06
Study of ARO-HBV in Normal Adult Volunteers and Patients With Hepatitis B Virus (HBV)
CompletedNCT03365947
Start: 2018-03-27End: 2020-04-23Updated: 2025-10-22
A Study to Evaluate the Effect of Itraconazole on JNJ-56136379 in Healthy Adult Participants
CompletedNCT03945539
Start: 2019-05-15End: 2019-10-04Updated: 2025-02-03
A Study to Evaluate the Effect of Hepatic Impairment on JNJ-56136379
CompletedNCT04208399
Start: 2020-01-09End: 2021-03-26Updated: 2021-04-20
A Study to Evaluate the Effect of Renal Impairment on JNJ-56136379 in Adult Participants
TerminatedNCT04474210
Start: 2020-08-19End: 2020-11-30Updated: 2021-07-23
A Study of JNJ-56136379 in Healthy Participants
WithdrawnNCT04853524
Start: 2021-05-06End: 2021-07-30Updated: 2021-07-15
Phase 2
An Efficacy, Safety, and Pharmacokinetics Study of JNJ-56136379 in Participants With Chronic Hepatitis B Virus Infection
CompletedNCT03361956
Start: 2018-02-13End: 2020-08-13Updated: 2022-11-17
A Study of Different Combination Regimens Including JNJ-73763989 and/or JNJ-56136379 for the Treatment of Chronic Hepatitis B Virus Infection
CompletedNCT03982186
Start: 2019-08-01End: 2022-04-26Updated: 2025-02-04
A Study of JNJ 73763989+JNJ 56136379+Nucleos(t)Ide Analog (NA) Regimen Compared to NA Alone in e Antigen Negative Virologically Suppressed Participants With Chronic Hepatitis B Virus Infection
CompletedNCT04129554
Start: 2019-11-06End: 2022-06-09Updated: 2025-02-04
A Study of JNJ-73763989, Pegylated Interferon Alpha-2a, Nucleos(t)Ide Analog (NA) With or Without JNJ-56136379 in Treatment-naive Participants With Hepatitis B e Antigen (HBeAg) Positive Chronic Hepatitis B Virus (HBV) Infection
CompletedNCT04439539
Start: 2020-09-14End: 2024-02-13Updated: 2025-06-24
A Study to Assess Intrahepatic and Peripheral Changes of Immunologic and Virologic Markers in Chronic Hepatitis B Virus Infection
CompletedNCT04585789
Start: 2021-03-11End: 2024-01-09Updated: 2025-05-21