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JNJ-42756493

DRUG11 trials

Sponsors

Janssen Cilag International, Het Nederlands Kanker Instituut-Antoni van Leeuwenhoek Ziekenhuis Stichting, Grupo Espanol De Oncologia Genitourinaria-Socug, Janssen Research & Development, LLC, University Health Network, Toronto

Conditions

Advanced Urothelial CancerAdvanced solid tumorAdvanced solid tumors (other than Urothelial tumors)Cohort 1 and 2: High Risk Non-Muscle-Invasive Bladder Cancer (NMIBC) with FGFR Mutations or Fusions Cohort 3 Intermediate Risk Non-Muscle-Invasive Bladder Cancer (NMIBC) with FGFR Mutations or FusionsFGFR+ Intermediate-risk Non-muscle Invasive Bladder CancerHealthyHigh-risk Non-muscle-invasive Bladder Cancer with Susceptible FGFR AlterationsMetastatic or Locally Advanced Urothelial Cancer

Phase 1

Phase 2

Testing JNJ-42756493 In Combination With Dexamethasone in Multiple Myeloma That Came Back After a Period of Improvement
TerminatedNCT02952573
University Health Network, TorontoMultiple Myeloma, Relapsed/Refractory
Start: 2017-06-13End: 2018-11-13Updated: 2020-09-17
A Phase 2, Two-arm Multicenter, Open-Label Study to Determine the Efficacy and the Safety of Two Different Dose Regimens of a pan-FGFR Tyrosine Kinase Inhibitor JNJ-42756493 in Subjects with Metastatic or Surgically Unresectable Urothelial Cancer with FGFR Genomic Alterations
Active, not recruitingCTIS2023-510273-34-00
Janssen Cilag InternationalUrothelial cancer
Start: 2015-04-24Target: 5Updated: 2025-08-22
A Phase 2 Study of Erdafitinib in Subjects with Advanced Solid Tumors and FGFR Gene Alterations
Active, not recruitingCTIS2023-510301-18-00
Janssen Cilag InternationalAdvanced solid tumors (other than Urothelial tumors), and FGFR gene alterations.
Start: 2019-12-05Target: 2Updated: 2025-08-06
A Dutch National Study on behalf of the Center for Personalized Cancer Treatment (CPCT) to Facilitate Patient Access to Commercially Available, Targeted Anti-cancer Drugs to determine the Potential Efficacy in Treatment of Advanced Cancers with a Known Molecular Profile: The Drug Rediscovery Protocol (DRUP trial)
RecruitingCTIS2023-509152-33-00
Het Nederlands Kanker Instituut-Antoni van Leeuwenhoek Ziekenhuis StichtingAdvanced solid tumor, Multiple myeloma, Non-Hodgkin lymphoma +1
Start: 2016-07-25Target: 3000Updated: 2025-12-19
A Randomized Phase 2 Study of Erdafitinib Versus Investigator Choice of Intravesical Chemotherapy in Subjects Who Received Bacillus Calmette-Guérin (BCG) and Recurred With High Risk Non-Muscle-Invasive Bladder Cancer (NMIBC) and FGFR Mutations or Fusions
CompletedCTIS2023-510306-40-00
Janssen Cilag InternationalCohort 1 and 2: High Risk Non-Muscle-Invasive Bladder Cancer (NMIBC) with FGFR Mutations or Fusions Cohort 3 Intermediate Risk Non-Muscle-Invasive Bladder Cancer (NMIBC) with FGFR Mutations or Fusions
Start: 2020-08-11End: 2025-02-27Target: 6Updated: 2025-01-22
A Phase 2, open-label, multi-centre, multi-national interventional trial to evaluate the efficacy and safety of erdafitinib (ERDA) monotherapy and erdafitinib (ERDA) and cetrelimab (CET) combination as neoadjuvant treatment in cisplatin-ineligible patients with muscle-invasive bladder cancer (MIBC) whose tumours express FGFR gene alterations (SOGUG-NEOWIN)
RecruitingCTIS2024-512573-27-01
Grupo Espanol De Oncologia Genitourinaria-SocugMuscle-invasive bladder cancer (MIBC)
Start: 2023-12-11Target: 62Updated: 2025-09-02

Phase 3

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