Jakavi 10 mg tablets
Sponsors
Karyopharm Therapeutics Inc., AbbVie Deutschland GmbH & Co. KG, Takeda Development Center Americas Inc., Medical Center - University Of Freiburg, Bristol-Myers Squibb Services Unlimited Company
Conditions
DIPSS-Intermediate or High Risk MyelofibrosisJAK inhibitor-naïve myelofibrosisMyelofibrosisMyeloproliferative NeoplasmsThis study is designed to accept patients with varied disease originsTreatment naïve patients with MFdepending on the parent protocolhaemophagocytic lymphohistiocytosis (HLH) in children
Phase 1
A Phase 1b/2 Study of BMS-986158 Monotherapy and in Combination with Either Ruxolitinib or Fedratinib in Participants with DIPSS-Intermediate or High Risk Myelofibrosis
Active, not recruitingCTIS2023-509635-89-00
Start: 2021-06-01Target: 132Updated: 2026-01-12
A Phase 1 Open-Label Study Evaluating the Safety and Tolerability, and Pharmacokinetics of Navitoclax Monotherapy and in Combination with Ruxolitinib in Myeloproliferative Neoplasm Subjects, Incorporating Extension Part 6 – Continued Access for Navitoclax to Roll Over Subjects in France and Bulgaria from Studies M16-191 and M20-178
Active, not recruitingCTIS2023-507274-40-00
Start: 2021-04-22Target: 60Updated: 2025-09-12
Phase 2
A Phase 2 study to evaluate the efficacy and safety of selinexor monotherapy in subjects
with JAK inhibitor-naïve myelofibrosis and moderate thrombocytopenia.
RecruitingCTIS2024-511309-47-00
Start: 2024-07-17Target: 38Updated: 2026-01-27
An Open-Label Clinical Trial of RVU120 as Monotherapy and in Combination with Ruxolitinib in Patients with Intermediate or High-Risk, Primary or Secondary Myelofibrosis (POTAMI-61)
RecruitingCTIS2024-511688-27-00
Start: 2024-09-19Target: 83Updated: 2025-12-16
A Phase 2 Open-Label Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Efficacy of KER-050 as Monotherapy or in Combination with Ruxolitinib in Participants with Myelofibrosis.
Active, not recruitingCTIS2023-507468-38-00
Start: 2022-04-22Target: 47Updated: 2025-12-16
Phase 2 Trial to determine the safety and efficacy of simultaneous treatment with ruxolitinib and extracorporeal photopheresis for patients with steroid-refractory chronic Graft-versus-Host-Disease (SR-cGvHD) - RUX-ECP
RecruitingCTIS2023-507754-33-00
Start: 2025-02-19Target: 40Updated: 2026-01-21
R-HLH - Efficacy of Ruxolitinib as first line treatment in primary haemophagocytic lymphohistiocytosis (HLH) in children: a Phase 2, multicentre, non-comparative study
RecruitingCTIS2024-516105-23-01
Start: 2024-11-10Target: 20Updated: 2024-12-16