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Jakavi 10 mg tablets

DRUG9 trials

Sponsors

Karyopharm Therapeutics Inc., AbbVie Deutschland GmbH & Co. KG, Takeda Development Center Americas Inc., Medical Center - University Of Freiburg, Bristol-Myers Squibb Services Unlimited Company

Conditions

DIPSS-Intermediate or High Risk MyelofibrosisJAK inhibitor-naïve myelofibrosisMyelofibrosisMyeloproliferative NeoplasmsThis study is designed to accept patients with varied disease originsTreatment naïve patients with MFdepending on the parent protocolhaemophagocytic lymphohistiocytosis (HLH) in children

Phase 1

Phase 2

A Phase 2 study to evaluate the efficacy and safety of selinexor monotherapy in subjects with JAK inhibitor-naïve myelofibrosis and moderate thrombocytopenia.
RecruitingCTIS2024-511309-47-00
Karyopharm Therapeutics Inc.JAK inhibitor-naïve myelofibrosis, moderate thrombocytopenia
Start: 2024-07-17Target: 38Updated: 2026-01-27
An Open-Label Clinical Trial of RVU120 as Monotherapy and in Combination with Ruxolitinib in Patients with Intermediate or High-Risk, Primary or Secondary Myelofibrosis (POTAMI-61)
RecruitingCTIS2024-511688-27-00
Ryvu Therapeutics S.A.Myelofibrosis
Start: 2024-09-19Target: 83Updated: 2025-12-16
A Phase 2 Open-Label Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Efficacy of KER-050 as Monotherapy or in Combination with Ruxolitinib in Participants with Myelofibrosis.
Active, not recruitingCTIS2023-507468-38-00
Takeda Development Center Americas Inc.Myelofibrosis
Start: 2022-04-22Target: 47Updated: 2025-12-16
Phase 2 Trial to determine the safety and efficacy of simultaneous treatment with ruxolitinib and extracorporeal photopheresis for patients with steroid-refractory chronic Graft-versus-Host-Disease (SR-cGvHD) - RUX-ECP
RecruitingCTIS2023-507754-33-00
Medical Center - University Of Freiburgsteroid-refractory chronic Graft-versus-Host-Disease
Start: 2025-02-19Target: 40Updated: 2026-01-21
R-HLH - Efficacy of Ruxolitinib as first line treatment in primary haemophagocytic lymphohistiocytosis (HLH) in children: a Phase 2, multicentre, non-comparative study
RecruitingCTIS2024-516105-23-01
Assistance Publique Hopitaux De Parishaemophagocytic lymphohistiocytosis (HLH) in children
Start: 2024-11-10Target: 20Updated: 2024-12-16

Phase 3

Phase 4