Ivonescimab Injection

BIOLOGICAL3 trials

Sponsors

Summit Therapeutics, Shanghai Allink Biotherapeutics Co., Ltd.

Conditions

NSCLC (Advanced Non-small Cell Lung Cancer)Non-Small Cell Lung Cancer

Phase 2

Phase II Clinical Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Antitumor Activity of ALK202 for Injection in Combination With Drugs in NSCLC Participants.

Not yet recruitingNCT07603791

Shanghai Allink Biotherapeutics Co., Ltd.NSCLC (Advanced Non-small Cell Lung Cancer)

Start: 2026-06-30End: 2028-12-30Target: 252Updated: 2026-05-22

Phase 3

Clinical Study of Ivonescimab for First-line Treatment of Metastatic NSCLC Patients

RecruitingNCT05899608

Summit TherapeuticsNon-Small Cell Lung Cancer

Start: 2023-10-26End: 2029-12-31Target: 1600Updated: 2026-04-30

Clinical Study of Ivonescimab for First-line Treatment of Metastatic NSCLC Patients With High PD-L1

RecruitingNCT06767514

Summit TherapeuticsNon-Small Cell Lung Cancer

Start: 2025-02-27End: 2029-06-01Target: 780Updated: 2026-02-24

Related Papers

A randomized phase 3 study of ivonescimab plus chemotherapy versus pembrolizumab plus chemotherapy for the first-line treatment of metastatic non–small cell lung cancer: HARMONi-3.

Journal of Clinical Oncology2025-05-28

Phase 1a dose escalation study of ivonescimab (AK112/SMT112), an anti-PD-1/VEGF-A bispecific antibody, in patients with advanced solid tumors

Journal for ImmunoTherapy of Cancer2024-04-0147 citations