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Ivonescimab (20mg/kg Q3W)

DRUG4 trials

Sponsors

QuantumLeap Healthcare Collaborative, Sheng Zhang, Zhejiang Cancer Hospital, Sichuan University

Conditions

AK112AngiosarcomaBreast CancerBreast NeoplasmsBreast TumorsEarly-stage Breast CancerGastric CancerHER2-negative Breast Cancer

Phase 2

I-SPY TRIAL: Neoadjuvant and Personalized Adaptive Novel Agents to Treat Breast Cancer
RecruitingNCT01042379
QuantumLeap Healthcare CollaborativeAngiosarcoma, Breast Cancer, Breast Neoplasms +8
Start: 2010-03-01End: 2031-12-01Target: 5000Updated: 2026-05-06
Ivonescimab (PD-1/VEGF Bispecific Antibody) Plus Radiofrequency Ablation for Multiple Advanced Tumors After PD-1 Therapy Failure
Not yet recruitingNCT07095803
Sheng ZhangMultiple Advanced Tumors After PD-1 Therapy Failure
Start: 2025-08-01End: 2027-02-01Target: 60Updated: 2025-07-31
SCRT Followed by AK112 in pMMR/MSS Mid-low Rectal Cancer
Not yet recruitingNCT07162714
Zhejiang Cancer HospitalAK112, Radiation, Rectal Cancer
Start: 2025-09-01End: 2028-12-31Target: 30Updated: 2025-09-09
Perioperative Ivonescimab Plus S-1 and Oxaliplatin (SOX) for Locally Advanced Gastric or GEJ Adenocarcinoma
Not yet recruitingNCT07374250
Sichuan UniversityGastric Cancer, RCT
Start: 2026-02-01End: 2027-12-31Target: 154Updated: 2026-01-28

Related Papers

Outcomes After Intratumoral Delivery of Immunotherapy in Breast Cancer.
2026-05-13
Longitudinal DCE MRI Vascular Textures: Radiologic and Biologic Insights for pCR Prediction in HER2-Negative Breast Cancer.
2026-03-25
Abstract PS3-11-10: Neoadjuvant HSP90 inhibition with ganetespib significantly improves distant relapse-free survival in I-SPY2 patients with HER2-negative breast cancer with low expression of immune genes and no DNA repair deficiency
Clinical Cancer Research2026-02-17
Abstract PS1-01-09: Real-time monitoring for drug-induced interstitial lung disease with Trastuzumab Deruxtecan and Rilvegostomig combination therapy prevents persistent, symptomatic disease: Safety insights from the I-SPY2.2 platform trial
Clinical Cancer Research2026-02-17
Abstract RF5-06: Pathologic complete response rates (pCR) after the novel HER2 ADC ARX788: Results from the I-SPY2.2 trial
Clinical Cancer Research2026-02-17
Abstract PS2-11-06: Quiescent-like phenotype characterizes treatment-resistant early-stage HER2-negative breast cancers and suggests novel therapeutic targets; analysis of over 2000 patients from the I-SPY2 trial
Clinical Cancer Research2026-02-17
CHFR expression and sensitivity of breast cancer cells to antimitotic agents in vitro and in the I-SPY trial.
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Serum estradiol (sE2) levels in premenopausal (PreM) women receiving neoadjuvant ovarian function suppression (OFS) with the oral SERD amcenestrant, alone, or in combination with letrozole or abemaciclib in the I-SPY2 Endocrine Optimization Pilot (EOP).
Journal of Clinical Oncology2025-05-28
I-SPY2 endocrine optimization pilot (EOP): Neoadjuvant lasofoxifene (Laso) in molecularly selected patients with hormone receptor positive (HR+)/HER2 negative (HER2-) stage 2/3 breast cancer (BC).
Journal of Clinical Oncology2025-05-28
Early adverse symptoms to predict response to treatment among patients in the I-SPY trial.
Journal of Clinical Oncology2025-05-28
Causal analyses of the impact of comorbid conditions and concomitant medications on response to neoadjuvant chemotherapy in breast cancer: analysis of a multicenter prospective cohort study (CANTO).
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