ITF2357
Sponsors
Italfarmaco S.p.A., Radboud University Medical Center, Italfarmaco
Conditions
Active SystemicAutoinflammatory SyndromesChronic Lymphocytic LeukemiaCrohn's DiseaseDuchenne Muscular Dystrophy (DMD)Duchenne muscular dystrophy (DMD)HIDSHepatic Impairment
Phase 1
Effect of ITF2357 on Mucosal Healing in Patients With Moderate-to-severe Active Crohn's Disease
TerminatedNCT00792740
Start: 2007-10-22End: 2009-03-11Updated: 2023-07-19
Trial of the Histone-Deacetylase Inhibitor ITF2357 Followed by Mechlorethamine in Relapsed/Refractory Hodgkin's Lymphoma
CompletedNCT00792467
Start: 2008-02-29End: 2010-09-30Updated: 2021-05-11
Pharmacokinetics, Safety and Tolerability of ITF2357 in Participants With Chronic Hepatic Impairment and With Normal Hepatic Function
CompletedNCT06736223
Start: 2025-05-29End: 2025-08-14Updated: 2026-06-18
Phase 2
The Efficacy and Safety of ITF2357 in AIS
NCT00442182
Start: 2006-09-30Target: 20Updated: 2007-03-01
Open Label, Multicentre Trial to Assess Safety and Efficacy of ITF2357 in Active Systemic Juvenile Idiopathic Arthritis
CompletedNCT00570661
Start: 2006-09-12End: 2013-06-10Updated: 2021-05-04
Phase IIA Study of the HDAC Inhibitor ITF2357 in Patients With JAK-2 V617F Positive Chronic Myeloproliferative Diseases
CompletedNCT00606307
Start: 2007-12-31End: 2008-12-31Updated: 2019-12-03
Phase II Study of Histone-deacetylase Inhibitor ITF2357 in Refractory/Relapsed Lymphocytic Leukemia
TerminatedNCT00792831
Start: 2008-02-29End: 2009-04-30Updated: 2022-01-27
Phase II Clinical Trial of ITF2357 In Patients With Relapsed/Refractory Multiple Myeloma
TerminatedNCT00792506
Start: 2008-10-31End: 2010-07-31Updated: 2022-02-02
A Phase 2 Open label (Core Phase Plus Extension Phase) With 2 Cohorts Study to Assess the Pharmacokinetics and Safety of Givinostat in DMD Patients Ages From at Least 2 Years to Less Than 6 Years Old
RecruitingCTIS2024-511823-32-00
Start: 2024-11-06Target: 10Updated: 2025-03-21
Phase 3
Randomised, double blind, placebo controlled, multicentre study to evaluate the efficacy, safety and tolerability of givinostat in non-ambulant patients with Duchenne Muscular Dystrophy
RecruitingCTIS2023-503521-19-00
Start: 2024-02-09Target: 90Updated: 2026-01-14
Open label, long-term safety, tolerability, and efficacy study of GIVINOSTAT in all DMD patients who have been previously treated in one of the GIVINOSTAT studies.
RecruitingCTIS2023-504520-26-00
Start: 2017-10-19Target: 120Updated: 2025-07-11